Two closely related nickel complexes have different effects on DNA damage and cell viability

Oxidative DNA cleavage by Schiff base tetraazamacrocyclic oxamido nickel(II) complexes

“…Some researches have shown that bound proteins or synthetic ligands may increase the toxic effect of nickel ions. However, up to now, the exact mechanism to involve carcinogenesis has not been fully elucidated [5]. The elucidation of the mechanism is essential not only for the risk assessment [6], but also for developing novel nickel complexes that have potential applications in medicine and research, such as inhibitors of cancer proliferation and useful DNA or RNA probes [7,8].…”

Nickel–quinolones interaction. Part 2 – Interaction of nickel(II) with the antibacterial drug oxolinic acid

“…Additionally, nickel complexes of biological interest have been reported with the most structurally characterized acting as antiepileptic [13], anticonvulsant [14] agents or vitamins [15] or showing antibacterial [16][17][18][19], anticancer/ antiproliferative [20][21][22][23][24][25][26], antifungal [16,27,28] and antimicrobial [29] activity. The interaction of Ni(II) complexes with DNA has been mainly dependent on the structure of the ligand exhibiting intercalative behavior [30][31][32] and/or DNA cleavage ability [33,34].…”

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

“…The interaction of Ni(II) complexes with DNA has been mainly dependent on the structure of the ligand exhibiting intercalative behavior [19][20][21][22][23] and/or DNA cleavage ability. 24,25 Serum albumin is the major soluble protein constituent in the circulatory system of a wide variety of organisms and it has the ability to reversibly bind to a large variety of endogenous and exogenous ligands such as fatty acids, drugs, and metal ions in the bloodstream. 26,27 The drug-protein complex not only strongly affected the absorption, distribution, metabolism and excretion properties of drugs, but also influenced the drug stability and toxicity during the chemotherapeutic process.…”