Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

Abstract

3 )] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(II) chelates have been screened for their scavenging effect towards O 2 − , OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.

Transition Metal Complexes with 1‐Adamantoyl Hydrazones – Cytotoxic Copper(II) Complexes of Tri‐ and Tetradentate Pyridine Chelators Containing an Adamantane Ring System

“…[17,18] In the spectra of 2, 4, and 5, which contain anionic chelate ligands, the band at ν ≈ 1300 cm -1 corresponds to the ν(C-O) vibration. [10,19] The deprotonation of the hydrazine nitrogen atom results in the formation of an azine group, ϾC=N-N=CϽ, which is manifested in the IR spectra of the complexes by the appearance of bands in the ν = 1613-1585 cm -1 range and the band at ν ≈ 1480 cm -1 . [19,20] The coordination of the pyridine nitrogen atom is indicated by a positive shift (ca.…”

“…Reaction mixtures (1 mL in 40 mm hydrogen carbonate buffer, pH 8.4) consisting of different concentrations of compounds (10,20, and 30 μm) and CT-DNA (138.6 μm) were incubated at 37°C for 60 min with occasional vortexing. The UV/Vis spectra were recorded with a Shimadzu UV-1800 UV/Vis spectrometer operating from λ = 200 to 800 nm with samples in 1.0 cm quartz cells.…”

“…The square-pyramidal and square-planar Cu II complexes derived from bis(benzoylhydrazone) showed superior DNA binding properties, [9] whereas Cu II complexes with ferrocene-based acylhydrazones exhibited significant cleavage of supercoiled pUC19 DNA in the presence of hydrogen peroxide as co-oxidant. [10] Cu II complexes prepared from acylhydrazone bearing a naphthalene ring bind to calf thymus DNA (CT-DNA) by both groove binding and intercalation; [11] furthermore, the Cu II acylhydrazone complex prepared from 2-acetylpyridine benzoylhydrazone indicated an intercalative mode of binding between the complex and CT-DNA. [6] Adamantane derivatives, seven of which have found use in clinical practice, [12,13] are rarely used as ligands.…”

A novel cationic copper(II) Schiff base complex: Synthesis, characterization, crystal structure, electrochemical evaluation, anti-cancer activity, and preparation of its metal oxide nanoparticles

“…Furthermore, these compounds show remarkable biological activities which are greatly related to their metal complexation ability [6].…”

Ru(II)‐η6‐benzene Complexes of Dibenzosuberenyl Appended Aroyl/Acylthiourea Ligands: In vitro Biomolecular Interaction Studies and Catalytic Transfer Hydrogenation

“…The observed red or blue shift revealed the interaction between the complexes and BSA at hydrophobic sites. [49] The fluorescence quenching constant (K q ) values were found by Stern-Volmer equation using of n (~1) strongly reinforced the presence of a single binding site in BSA. The values of K b suggested that complex 1 interacted with BSA rather strongly relative to the other complexes.…”