Two mononuclear ruthenium complexes (1 and 2) with aroyl/acylthiourea as an ancillary ligand of type, [(η6‐p‐cymene)RuCl(L‐N,S)], where [L1 = 2,4‐dichloro‐N‐(o‐tolylcarbamothioyl)benzamide] and L2 = N‐(phenylcarbamothioyl)cyclohexanecarboxamide] were synthesized and well characterized. The single crystal X‐ray diffraction studies revealed the coordination mode and the geometry of the complexes. The two complexes adopted general piano‐stool (three‐legged) geometry with a novel coordination mode of aroyl/acylthiourea through amide N (anionic) and thiocarbonyl S (neutral). This type of monobasic bidentate coordination of the aroyl/acylthiourea ligand was witnessed the first time around the metal ion. The coordination of the complexes was well explained through geometric parameters and frontier molecular orbital parameter values computed at the B3LYP/SDD level. The synthesized complexes were also screened for their antibacterial, antifungal, antioxidant and in vitro antiproliferative activities. Complexes exhibited good antimicrobial agents against various pathogens. The antioxidant activity of the complex 2 has shown most potent activity with IC50 value of 48.55 ± 1.7 μM compared to the reference drug. In addition, the in vitro antiproliferative activity of the complex 2 showed excellent activity against HepG‐2 cell line with the IC50 value of 24.30 ± 1.20 μM which is close to Doxorubicin standard drug.
A series of novel N-dibenzosuberene appended aroyl/acylthiourea ligands (L1-L4) and their Ru(II)-benzene complexes (1-4), [RuCl 2 (h 6 -benzene)L] (L = monodentate aroyl/acylthiourea ligand) was synthesized and well characterized. The coordination mode of aroyl/acylthiourea ligand with Ru ion through S (neutral monodentate) donor atom was determined by single crystal X-ray diffraction analysis. In vitro Calf thymus DNA (CT-DNA) and Bovine serum albumin (BSA) interaction of the complexes were investigated by UV-Visible, fluorescence spectroscopic and hydrodynamic methods. The results showed the intercalative mode of binding (in the order of 1 > 4 > 3 > 2) of the Ru(II)-benzene complexes with CT-DNA. The DNA (pUC19) cleavage study showed that the complexes cleaved DNA through a hydrolytic pathway. All the complexes have been thoroughly screened for their cytotoxicity against human liver carcinoma (HepG-2) and lung cancer (A549) cells under in vitro conditions. Complex 1 exhibited significant cytotoxic activity (IC 50 = 46.1 mM) towards HepG-2 cancer cell line. In addition to this, the prepared complexes have been utilized as catalyst precursors for transfer hydrogenation (TH) of ketones, aldehydes and nitro compounds using 2-propanol as a hydrogen source. The TH reactions proceeded with exceptional conversions (up to 99%) and the present catalytic system was extended to substituted aromatic/heterocyclic carbonyl and nitro compounds.
Four novel Pd (II)-thiourea square-planar derivatives of the type [PdCl 2 L 2 ] (L = N-dibenzosuberenyl appended aroyl/acylthiourea ligand) (1-4) were synthesized and well characterized. The neutral monodentate S coordination of ligand with palladium (II) ion was confirmed by single crystal X-ray diffraction method. In vitro calf thymus DNA (CT-DNA) interaction studies were investigated, and the results of the complexes showed the intercalative mode of binding (in the order of 1 > 3 > 2 > 4) with complexes. The binding affinity of the compounds with bovine serum albumin (BSA) was studied, and it was found that the binding affinity of the complexes with DNA and BSA was different. In addition, the antimicrobial activity evaluation results revealed that compound 2 has registered excellent antibacterial activity against four strains, and also compounds 2 and 4 have shown good antifungal activity against the microorganisms compared with their reference drugs. The scavenging activity of compound 3 showed potent activity with an IC 50 value of 6.95 ± 1.81 μM. Furthermore, the in vitro anti-proliferative activity results clearly suggested that complex 3 showed most potent cytotoxic activity against human neuroblastoma (IMR-32) cell line, with an IC 50 value of 15.21 ± 0.359 μM compared with the reference drug.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.