Oxidative DNA cleavage by Schiff base tetraazamacrocyclic oxamido nickel(II) complexes

Kong, De‐Ming; Wang, Jiao; Zhu, Lina; Yong, Jin; Li, Xiao‐Zeng; Shen, Han‐Xi; Mi, Huaifeng

doi:10.1016/j.jinorgbio.2007.12.002

Cited by 91 publications

(23 citation statements)

References 28 publications

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“…Whenever a H 2 O molecule is coordinated to a metal ion in the axial position, this H 2 O molecule is activated, producing a nucleophillic M-OH species that participates in DNA cleavage [53,54]. With previous literature indicating the ability of copper [55,56], nickel [57,58], and cobalt [59,60] complexes to interact with DNA, we further investigated the propensity of these complexes to interact with DNA using circular dichroism spectral studies.…”

Section: Dna Gel Mobility Assaymentioning

confidence: 99%

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun

Higbee

Ouellette

et al. 2009

Journal of Inorganic Biochemistry

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Section: Dna Gel Mobility Assaymentioning

confidence: 99%

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun

Higbee

Ouellette

et al. 2009

Journal of Inorganic Biochemistry

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“…In contrast, the nickel(II) complexes of macrocyclic polyamines with two phenol groups have received much less attention. In fact, nickel(II) complexes with macrocyclic ligands were also found to have potential DNA cleavage reactivity [8]. In this paper, we report the synthesis of a new nickel(II) complex of a polyamine macrocyclic ligand with two phenol groups by template synthesis, as shown in Scheme 1.…”

Section: Introductionmentioning

confidence: 98%

Synthesis, crystal structure, and DNA cleavage activity of a dinuclear nickel(II) complex with a macrocyclic ligand

Chen

Zhou

et al. 2011

Transition Met Chem

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A new Ni(II) complex, namely [Ni 2 (OAc)L]Á ClO 4 ÁH 2 O, was synthesized by [2 ? 2] cyclo-condensation between 2,6-diformyl-4-methylphenol and N,N-bis(3-aminopropyl)-4-methoxybenzylamine (amba) in the presence of nickel(II) and characterized by spectroscopy, elemental analysis, and X-ray single crystal diffraction. The interactions of the complex with DNA have been measured by spectroscopy and viscosity measurements. Absorption spectroscopic investigation reveals intercalative binding of the Ni(II) complex with DNA, with a binding constant of 2.6 9 10 4 M -1 . Fluorescence spectroscopy shows that the Ni(II) complex can displace ethidium bromide and bind to DNA, with a quenching constant of 7.57 9 10 3 M -1 . The appearance of increased CD bands near 245 and 275 nm gives evidence for effective complex DNA binding. The agarose gel electrophoresis studies show that the complex displays effective DNA cleavage activity in the absence of any external agents.

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“…Interactions of DNA with complexes of many transition metal ions have been investigated (Sigman et al, 1993;Vaidyanathan and Nair, 2003). Nickel(II) complexes are least known for bringing about DNA cleavage according to literature and only few of them can bring about an oxidative cleavage of DNA (Boerner and Zaleski, 2005;Kong et al, 2008;McLachlan et al, 1996;Stuart et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

Patel

Pansuriya

2010

Med Chem Res

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Dinuclear nickel(II) complexes of type [Ni 2 (L) 2 (cpf) 2 (H 2 O) 2 ]Á2H 2 O have been synthesized and characterized using spectral, physicochemical, mass spectra and elemental analyses. Antimicrobial efficacy of the compounds has been screened against five different microorganisms. Interestingly, all complexes demonstrated potent in-vitro antibacterial activity against gram-positive Staphylococcus aureus, Bacillus subtilis, and gram-negative Pseudomonas aeruginosa, Serratia marcescens, and Escherichia coli bacteria. Moreover, the interactions of the prepared complexes with DNA helix were studied using absorption titrations, gel electrophoresis, and viscometric techniques.

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Oxidative DNA cleavage by Schiff base tetraazamacrocyclic oxamido nickel(II) complexes

Cited by 91 publications

References 28 publications

Pyrophosphate-bridged complexes with picomolar toxicity

Pyrophosphate-bridged complexes with picomolar toxicity

Synthesis, crystal structure, and DNA cleavage activity of a dinuclear nickel(II) complex with a macrocyclic ligand

DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

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