DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

Patel, Mohan N.; Patel, S. H.; Pansuriya, Pramod B.

doi:10.1007/s00044-010-9486-z

Cited by 16 publications

(7 citation statements)

References 43 publications

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“…The N-O bending band appears in the region between 850 and 750 cm -1 . The absorption bands observed at 560-500 and 467-410 cm -1 are attributed to ν(M-N) and ν(M-O), respectively 27 . The ν(M-N) stretching frequency also exhibited in the range of 290-230 cm -1 28 .…”

Section: Resultsmentioning

confidence: 95%

Spectral Characterization and Biological Studies on Mixed Ligand Complexes of Cr(III), Ni(II) and Cu(II) Derived from 3-Aminopyridine and Nitrite Ion

Dhaveethu¹,

Ramachandramoorthy²,

Thirunavukkarasu³

2014

Asian J. Chem.

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The biological activity of the aminopyridines and their transition metal complexes act as K + and Ca 2+ channel inhibitors has been discussed in the literature 1,2. 3-aminopyridine (3AP) possesses significant antiproliferative, antiinflammatory and antibacterial activities 3 and furthermore, an antitumor activity of its derivatives has also proposed 4. Metal aminopyridine complexes are generally used as asymmetric catalysts for various reactions such as hydrogenation, cyclopropanation, epoxidation etc 5. The versatile coordination modes of the ambidentate ligand nitrite ion (NO2-) were previously reported 6. Metal nitrito complexes (M-ONO) are in general used as photochemical NO precursors 7. The transition metal complexes have many applications in pharmaceutical industries, biology and medicine. They posses electrical, thermo chromic, catalytic, antibacterial and antifungal properties 8 , Metal complexes of chromium, nickel and copper have a wide range of applications such as dyes and pigments 9. Many drugs possess modified toxicological and pharmacological properties in the form of metal complexes and the most widely studied in this respect is the Cu(II) ion which has proved beneficial in many diseases such as tuberculosis, gastric ulcers, rheumatoid arthritis and cancers 10. Copper complexes are currently being investigated for their potential anticancer activity. Moreover, coordination with copper often enhances the activity of various types of drugs such as antitumor and antiinflammatory agents 11 .

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Section: Resultsmentioning

confidence: 95%

Spectral Characterization and Biological Studies on Mixed Ligand Complexes of Cr(III), Ni(II) and Cu(II) Derived from 3-Aminopyridine and Nitrite Ion

Dhaveethu¹,

Ramachandramoorthy²,

Thirunavukkarasu³

2014

Asian J. Chem.

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“…Kb of the complex is calculated from the ratio of slope to intercept in the plot of [DNA] vs [DNA]/(εa-εf). [25]…”

Section: Uv-visible Absorption Titrationmentioning

confidence: 99%

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Saritha

Reddy

Sireesha

2021

Vietnam Journal of Chemistry

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The synthesis, characterization of mixed ligand chelates of Ni(II), [NiAL] involving Pyridoxalthiosemicarbazone (A) and dipeptides (L) viz., glycyl‐glycine (gly‐gly), glycyl‐L‐leucine (gly‐leu), glycyl‐L‐tyrosine (gly‐tyr) and glycyl‐L‐valine (gly‐val) and their biological activities have been studied. The complexes were characterized based on their elemental analysis, LC‐MS, IR, UV‐Vis spectral studies, magnetic moment, molar conductance and thermal analysis. The mixed ligand complexes were formed with 1:1:1 (Ni:A:L) ratio. The molar conductance data reveal the non‐electrolytic nature of the metal chelates. IR spectra show that the ligands are coordinated to the metal ion in a tridentate manner, involving O,N,S and O,N,N donor sites of ligands, A and L respectively. Based on the analytical data, octahedral geometry has been proposed for the metal complexes. DNA binding properties of the complexes have been investigated by UV‐Vis and fluorescence spectroscopy and also by viscosity measurements. The obtained results indicate that the complexes bind to DNA through intercalation mode, which is further validated by molecular docking studies. The hydrolytic cleavage of the pBR322 DNA from supercoiled to nicked form, by the metal complexes was investigated by gel electrophoresis technique. The metal complexes were also screened for their antioxidant, anti‐inflammatory and antibacterial activities and the findings have been reported.

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“…31 The absorption band, observed at 500-560 cm −1 can be attributed to ν(M−N). 32 The ν(M−N) stretching frequency is also expected in the range of 230-290 cm −1 in Far-IR spectra.…”

mentioning

confidence: 93%

Spectroscopic, Thermal and Biological Studies of Zn(II), Cd(II) and Hg(II) Complexes Derived from 3-Aminopyridine and Nitrite Ion

Dhaveethu¹,

Ramachandramoorthy²,

Thirunavukkarasu³

2013

Journal of the Korean Chemical Society

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ABSTRACT. Microwave assisted syntheses of Zn(II), Cd(II) and Hg(II) complexes with 3-aminopyridine (3AP) and nitrite (NO2 − ) ions have been reported. The metal complexes were characterized by elemental analyses, molar conductance, IR, Far-IR, electronic, NMR ( 1 H, 13 C), thermal and electron impact mass spectral studies. The spectroscopic studies reveal the composition, the nature of nitrite ligand in the complexes, electronic transitions, chemical environments of C and H atoms thermal degradation of the complexes. On the basis of characterization data, distorted tetrahedral geometry is suggested for Zn(II), Cd(II) and Hg(II) complexes. The organic ligand (3AP) and their metal complexes were screened against gram negative pathogenic bacteria and fungi in vitro. The results are compared with our previous report J. Korean Chem. Soc. 2013, 57, 341 on 4-aminopyridine and nitrite ion complexes of the same metal ions.

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DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

Cited by 16 publications

References 43 publications

Spectral Characterization and Biological Studies on Mixed Ligand Complexes of Cr(III), Ni(II) and Cu(II) Derived from 3-Aminopyridine and Nitrite Ion

Spectral Characterization and Biological Studies on Mixed Ligand Complexes of Cr(III), Ni(II) and Cu(II) Derived from 3-Aminopyridine and Nitrite Ion

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Spectroscopic, Thermal and Biological Studies of Zn(II), Cd(II) and Hg(II) Complexes Derived from 3-Aminopyridine and Nitrite Ion

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