Spectroscopic, Thermal and Biological Studies of Zn(II), Cd(II) and Hg(II) Complexes Derived from 3-Aminopyridine and Nitrite Ion

Abstract

ABSTRACT. Microwave assisted syntheses of Zn(II), Cd(II) and Hg(II) complexes with 3-aminopyridine (3AP) and nitrite (NO2 − ) ions have been reported. The metal complexes were characterized by elemental analyses, molar conductance, IR, Far-IR, electronic, NMR ( 1 H, 13 C), thermal and electron impact mass spectral studies. The spectroscopic studies reveal the composition, the nature of nitrite ligand in the complexes, electronic transitions, chemical environments of C and H atoms thermal degradation of the complexes. On the basis of characterization data, distorted tetrahedral geometry is suggested for Zn(II), Cd(II) and Hg(II) complexes. The organic ligand (3AP) and their metal complexes were screened against gram negative pathogenic bacteria and fungi in vitro. The results are compared with our previous report J. Korean Chem. Soc. 2013, 57, 341 on 4-aminopyridine and nitrite ion complexes of the same metal ions.

Theoretical calculations for new coumarin Schiff base complexes as candidates for in vitro and in silico biological applications

“…[ 8,9 ] Because of their wide range of applications, transition metal complexes are studied by inorganic, metallo‐organic, and bio‐inorganic chemists. [ 10 ] Drug combinations have long been recognized as an important part of antimicrobial therapy for a variety of reasons: (i) Enhancing activity by utilizing compounds with synergistic or additive activity; (ii) combating drug resistance; (iii) reducing required doses, cutting both cost and toxic side effects; (iv) broadening the range of activity. When delivered in the form of metal‐based compounds, certain biologically active chemicals that were previously used as medications have different pharmacological and toxicological properties.…”

Synthesis, spectroscopic, thermal, crystal structure properties, and characterization of new Hofmann-Td-type complexes with 3-aminopyridine

“…All of the aminopyridines are frequently used in medicine and to obtain new chemical compounds. A great deal of information can be found in the studies of our and other researchers about aminopyridines, which are very important compounds in the field of science and technology [11,12,[26][27][28][29][30][31][32][33][34][35][36].…”