TWIST1 upregulation affects E-cadherin expression in brain metastases

Brlek, Petar; Bukovac, Anja; Kafka, Anja; Pećina‐Šlaus, Nives

doi:10.1007/s12094-020-02496-3

Cited by 13 publications

(7 citation statements)

References 38 publications

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“…Its expression is required for normal embryogenesis, but is often upregulated during tumorigenesis and development [ 42 ]. Studies have shown that Twist1 binds to other bHLH dimers and regulates the transcription of EMT-related genes, and is involved in the metastasis of various cancers [ 43 ]. For example, Twist1 promotes the metastasis of osteosarcoma by up-regulating the expression of PCOLCE [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

et al. 2023

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Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA splicing, but also in the regulation of transcription, translation, and cell signaling, and its dysregulation contributes to various diseases including Nager syndrome and tumorigenesis. However, the role of SF3B4 and underlying mechanisms in clear cell renal cell carcinoma (ccRCC) remain obscure. In the present study, we found that the expression of SF3B4 was significantly elevated in ccRCC tissues and negatively correlated with the overall survival of ccRCC patients. Upregulation of SF3B4 promotes migration and invasion of ccRCC cells in vitro and in vivo. The promoting effect of SF3B4 on cell migration and invasion is mediated by Twist1, a key transcription factor to mediate EMT. Interestingly, SF3B4, a component of the pre-mRNA spliceosome, is able to promote KLF16 expression by facilitating the transport of KLF16 mRNA into the cytoplasm. Mechanistically, SF3B4 promotes the export of KLF16 mRNA from the nucleus to the cytoplasm and thus enhances KLF16 expression, and in turn elevated KLF16 directly binds to the Twist1 promoter to activate its transcription, leading to EMT and ccRCC progression. Our findings provide evidence that the SF3B4-KLF16-Twist1 axis plays important functional roles in the development and progression of ccRCC, and manipulating this pathway may be a novel therapeutic target for the treatment of ccRCC.

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Section: Discussionmentioning

confidence: 99%

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

et al. 2023

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“…There are several EMT markers in gynecological cancers, such as E-cadherin, N-cadherin, alpha-catenin, beta-catenin, and vimentin. The expression of E-cadherin and its transcriptional repressor TWIST1 has been demonstrated as markers indicating an epithelial–mesenchymal transition (EMT) in metastatic tumors originating from different primary sites [ 105 ]. These markers are discussed as potential therapeutic targets in these cancers [ 106 ].…”

Section: Epithelial–mesenchymal Transition In the Context Of Mesenchy...mentioning

confidence: 99%

Unlocking the Potential of Mesenchymal Stem Cells in Gynecology: Where Are We Now?

Erceg Ivkošić,

Fureš,

Ćosić

et al. 2023

JPM

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Stem cells, with their remarkable capacity for differentiation into diverse cell types, are vital for the development as well as maintenance of health and homeostasis. Two unique abilities set them apart from other cells: self-renewal and the capacity for differentiation. They play important roles in embryogenesis, development, regeneration, and various other processes. Over the last decade, there has been increased interest in their potential use in the treatment of numerous diseases and disorders across multiple fields of medicine in acute, chronic, innate, and acquired diseases. Stem cells are key to maintaining the body’s homeostasis and regulating growth and tissue functions. There are several types of stem cells—embryonic, adult, and human-induced pluripotent cells. Currently, mesenchymal stem cells are of great interest due to their regenerative, immunomodulatory, analgesic, and antimicrobial (anti-inflammatory) effects. Recent studies have shown the potent regenerative effect of stem cell therapy in gynecologic diseases such as infertility, Asherman syndrome, lichen sclerosus, polycystic ovary syndrome, premature ovarian insufficiency, genitourinary syndrome of menopause, and rectovaginal fistulas. Moreover, the successful isolation of oogonial stem cells could lead to a revolution in the field of gynecology and the potential treatment of the conditions discussed. This review aims to provide a better understanding of the latest therapeutic options involving stem cells and raise awareness of this promising yet not widely known topic in gynecology and medicine in general.

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“…β-catenin plays an essential role in tumor cell proliferation, and LEF1 cooperates with β-catenin to accelerate tumor development [ 53 ]. GATA3 and TWIST1 are involved in the E-cadherin expression [ 53 , 59 , 60 ], which determines how potent the tumor cell migration is. Targeted gene alterations by epigenetic modifications negatively regulate E-cadherin expression and enhance tumor cell migration.…”

Section: Epigenetics Modification In Ctclmentioning

confidence: 99%

Epigenetics of Cutaneous T-Cell Lymphomas

Hara

Sawada

2022

IJMS

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Epigenetic modifications rarely occur in isolation (as single “epigenetic modifications”). They usually appear together and form a network to control the epigenetic system. Cutaneous malignancies are usually affected by epigenetic changes. However, there is limited knowledge regarding the epigenetic changes associated with cutaneous lymphomas. In this review, we focused on cutaneous T-cell lymphomas such as mycosis fungoides, Sézary syndrome, and anaplastic large cell lymphoma. With regard to epigenetic changes, we summarize the detailed chemical modifications categorized into DNA methylation and histone acetylation and methylation. We also summarize the epigenetic modifications and characteristics of the drug for cutaneous T-cell lymphoma (CTCL). Furthermore, we discuss current research on epigenetic-targeted therapy against cutaneous T-cell lymphomas. Although the current method of treatment with histone deacetylase inhibitors does not exhibit sufficient therapeutic benefits in all cases of CTCL, epigenetic-targeted combination therapy might overcome this limitation for patients with CTCL.

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TWIST1 upregulation affects E-cadherin expression in brain metastases

Cited by 13 publications

References 38 publications

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

Unlocking the Potential of Mesenchymal Stem Cells in Gynecology: Where Are We Now?

Epigenetics of Cutaneous T-Cell Lymphomas

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