Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university students

Abstract

Background/Objectives: We examined the association between 24-h urinary excretion of water-soluble vitamin levels and their intakes in free-living Japanese university students. The design used was cross-sectional study. Subjects/Methods: A total of 216 healthy, free-living male and female Japanese university students aged 18-27 years voluntarily participated in this study, of which 156 students were eligible for this assessment. All foods consumed for 4 consecutive days were recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of water-soluble vitamins were measured. Mean estimated water-soluble vitamin intakes calculated from urinary levels and recovery rates showed 91-101% of their 3-day mean intakes, except for vitamin B 12 (61%). Conclusions: These results showed that urinary water-soluble vitamin levels, except for vitamin B 12 , reflect their recent intakes in free-living Japanese university students, and could be used as a potential biomarker to estimate mean vitamin intake.

Time-Dependent Effects of L-Tryptophan Administration on Urinary Excretion of L-Tryptophan Metabolites

“…We previously reported that the dietary intakes of vitamins B2 and B6 were 1.2 mg/d and 0.8 mg/d, respectively (1). These values are consistent with the average daily intake of these vitamins in healthy young women (26), indicating that our subjects were not vitamin B2-or vitamin B6-deficient. Therefore, the present data indicated that increasing urinary excretion of l-Trp metabolites was not related to vitamin B2 or vitamin B6 deficiency, and additional dietary supplementation of these vitamins was not necessary, even when the subjects were administered 5.0 g/d l-Trp for 21 d.…”

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

“…Table 4. Correlations between 24-hr urinary excretion and mean vitamin intakes, recovery rates, and mean estimated intakes in young Japanese (n=148) (Tsuji et al, 2010a).…”

“…Japanese elderly females aged 70-84 years were participated (Tsuji et al, 2010a(Tsuji et al, , 2010b(Tsuji et al, , 2011. The subjects performed 4-day dietary assessment by recording all food consumed during the consecutive 4-day period with a weighed food record, and collected 24-hr urine samples on the fourth day.…”

“…The results showed that the correlation between the urinary excretion and the dietary intake on the same day as urine collection was highest compared with the correlations on other days in each generation (Table 1- Table 1. Measured values for 24-hr urinary excretion collected on Day 4 and daily vitamin intake for each water-soluble vitamin, and correlation between 24-hr urinary excretion and daily vitamin intake in young Japanese (n=148) (Tsuji et al, 2010a).…”

Scientific Opinion on Dietary Reference Values for niacin

“…A significant linear correlation was observed between 24-hour urinary excretion of NMN, 2-Pyr, 4-Pyr or the sum of the three metabolites and usual dietary intake of niacin and/or NE (mean intake of about 21-27 mg NE/day) in healthy men and women (18-27 years) (Shibata and Matsuo, 1989;Tsuji et al, 2010) and children (10-12 years) (Tsuji et al, 2011). A significant correlation between NE intakes and 24-hour urinary excretion of NMN and 2-Pyr (average of four days per subject) was also observed in three groups of young men (19-28 years) given 8 mg/day of niacin and different tryptophan doses (total intake of about 12-22 mg NE/day, each of the three doses being consumed for 35 days) (Patterson et al, 1980).…”