Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

Fukuwatari, Tsutomu; Shibata, Katsumi

doi:10.5772/37616

Cited by 1 publication

(3 citation statements)

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“…Therefore, the measurement of the urinary B-group vitamins, except for vitamin B 12 , is a suitable method for individual nutritional status assessment. The present data complement our previous proposal that the urinary excretion of B-group vitamins reflects the nutritional status of these vitamins ( 14 – 21 , 41 ) .…”

Section: Discussionsupporting

confidence: 90%

“…This method has been applied to evaluate human nutritional status ( 21 , 41 ) . However, the question remains as to whether the urinary excretion of B-group vitamins decreases immediately before animals and human subjects become B-group vitamin insufficient or when they are fed a diet low in vitamins.…”

Section: Discussionmentioning

confidence: 99%

“…We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins ( 14 – 21 ) , and proposed reference values of the urinary levels of B-group vitamins for evaluating nutritional status. This method has been applied to evaluate human nutritional status ( 21 , 41 ) . However, the question remains as to whether the urinary excretion of B-group vitamins decreases immediately before animals and human subjects become B-group vitamin insufficient or when they are fed a diet low in vitamins.…”

Section: Discussionmentioning

confidence: 99%

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Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats

et al. 2013

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We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question arises as to whether the urinary excretion of B-group vitamins in animals or human subjects decreases immediately before they become B-group vitamin insufficient or when fed a diet low in vitamins. In the present study, rats were fed a vitamin-free diet for 5 d, and changes in the levels of B-group vitamins in urine and blood were monitored. Urinary excretion of vitamin B1, vitamin B2, 4-pyridoxic acid (a catabolite of vitamin B6), pantothenic acid, folate and biotin steeply decreased, and all of the values reached zero within 1–2 d. With respect to blood, the concentrations of only three of the eight B-group vitamins (vitamin B1, pyridoxal phosphate and biotin) decreased to 15 % (P < 0·0001), 7 % (P < 0·0001) and 2 % (P < 0·0001) on day 5, respectively, compared with the values at the beginning of the experiment. The decrease was more rapid and the changes were greater in the urine samples than in the blood samples. The present data complement our previous proposal that the urinary excretion of B-group vitamins reflects the nutritional status of these vitamins.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%