Time-Dependent Effects of L-Tryptophan Administration on Urinary Excretion of L-Tryptophan Metabolites

Hiratsuka, Chiaki; Sano, Mitsue; Fukuwatari, Tsutomu; Shibata, Katsumi

doi:10.3177/jnsv.60.255

Cited by 13 publications

(13 citation statements)

References 21 publications

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“…This period of 5 days was considered to permit attainment of a steady nutritional status for these vitamins. 12 , 13 Approximately one-fold, three-fold, and seven-fold amounts of synthesized water-soluble vitamin mixtures as vitamin mixtures “α”, “β”, and “γ” as shown in the DRI-J (2010) 10 were made ( Table 2 ). Participants were given only the diet for the first week, the diet with vitamin mixture-α for the second week, the diet with vitamin mixture-β for the third week, and the diet with vitamin mixture-γ for the fourth week.…”

Section: Methodsmentioning

confidence: 99%

Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine

Shibata

Hirose

Fukuwatari

2015

Int J�Tryptophan�Res

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Tryptophan metabolism is directly involved with B-group vitamins such as vitamin B2, niacin, and vitamin B6, and indirectly with vitamin B1 and pantothenic acid. We evaluated the validity of requirements of B-group vitamins set by the Dietary Reference Intakes for the Japanese (DRI-J). We investigated the fate of dietary tryptophan in 10 Japanese adult men who ate the same diet based on DRI-J during a 4-week study. Vitamin mixtures were administered based on the amounts in the basal diet during weeks 2, 3, and 4. Daily urine samples were collected eight times (days 1 and 5 in each week). Administration of vitamin mixtures had no effect on tryptophan metabolites such as anthranilic acid, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, and quinolinic acid within individuals. Surplus administration of B-group vitamins against DRI-J requirements did not elicit beneficial effects on tryptophan metabolism. Our findings supported the requirements of B-group vitamins set by the DRI-J.

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Section: Methodsmentioning

confidence: 99%

Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine

Shibata

Hirose

Fukuwatari

2015

Int J�Tryptophan�Res

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“…Further details on formation and disposition of bile acids, including glycochenodeoxycholate sulfate, are described in Biomarkers for Function of Organic Anion Transporting Polypeptides. Somogyi et al, 1990;Weber et al, 1991;Musfeld et al, 2001;Fukuwatari et al, 2004;Menon et al, 2007;Ito et al, 2012a;Hiratsuka et al, 2014;Müller et al, 2015 Thiamine Essential vitamin 265.4…”

Section: B Biomarkers For Function Of Organic Anion Transportersmentioning

confidence: 99%

“…N 1 -Methylnicotinamide. N 1 -Methylnicotinamide (1-methylnicotinamide, 1-methylpyridin-1-ium-3carboxamide) is a product of tryptophan and niacin metabolism (Fukuwatari et al, 2004;Menon et al, 2007;Hiratsuka et al, 2014). It is synthesized from nicotinamide by cytosolic nicotinamide N-methyltransferase (NNMT) using S-adenosyl-L-methionine as methyl donor (Rini et al, 1990;Aksoy et al, 1994;van Haren et al, 2016) and is then further metabolized by cytosolic aldehyde oxidase to two metabolites, N 1 -methyl-2-pyridone-5carboxamide (2-Py) and N 1 -methyl-4-pyridone-3-carboxamide (4-Py) (Kitamura et al, 2008).…”

Section: Biomarkers For Function Of Renal Cation Transporters (Orgmentioning

confidence: 99%

“…4-Py in humans (Shibata and Matsuo, 1989;Shibata, 1990;Pumpo et al, 2001;Fukuwatari et al, 2004). Amounts of N 1 -methylnicotinamide, 2-Py, and 4-Py excreted in urine depend on intake of tryptophan and niacin (Shibata and Matsuo, 1989;Hiratsuka et al, 2014). Physical stress in form of exposure to cold temperature has been reported to increase urinary excretion of N 1methylnicotinamide and the sum of N 1 -methylnicotinamide and its two metabolites (Okamoto et al, 2003).…”

Section: Biomarkers For Function Of Renal Cation Transporters (Orgmentioning

confidence: 99%

“…Porphyrias, Dubin-Johnson and Rotor syndrome Kaplowitz et al, 1972;Wolkoff et al, 1976;Puy et al, Abel et al, 1992;Seidegård et al, 1998;Fuhr et al, 2002;Shibuya et al, 2003;Peng et al, 2011;Imamura et al, 2013;Esche et al, Cazzullo et al, 1976;Barlow et al, 1977;Shibata and Matsuo, 1989;Rini et al, 1990;(continued ) Biomarkers for Assessment of Transporter Function Maiza et al, 1992;Aksoy et al, 1994;Gorboulev et al, 1997;Orlando et al, 2000;Pumpo et al, 2001;Masuda et al, 2006;Kitamura et al, 2008;Ito et al, 2012a;Hirats...…”

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confidence: 99%

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Biomarkers for In Vivo Assessment of Transporter Function

Müller¹,

Sharma²,

König³

et al. 2018

Pharmacol Rev

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Drug-drug interactions are a major concern not only during clinical practice, but also in drug development. Due to limitations of in vitro-in vivo predictions of transporter-mediated drug-drug interactions, multiple clinical Phase I drug-drug interaction studies may become necessary for a new molecular entity to assess potential drug interaction liabilities. This is a resource-intensive process and exposes study participants, who frequently are healthy volunteers without benefit from study treatment, to the potential risks of a new drug in development. Therefore, there is currently a major interest in new approaches for better prediction of transporter-mediated drug-drug interactions. In particular, researchers in the field attempt to identify endogenous compounds as biomarkers for transporter function, such as hexadecanedioate, tetradecanedioate, coproporphyrins I and III, or glycochenodeoxycholate sulfate for hepatic uptake via organic anion transporting polypeptide 1B or N-methylnicotinamide for multidrug and toxin extrusion protein-mediated renal secretion. We summarize in this review the currently proposed biomarkers and potential limitations of the substances identified to date. Moreover, we suggest criteria based on current experiences, which may be used to assess the suitability of a biomarker for transporter function. Finally, further alternatives and supplemental approaches to classic drug-drug interaction studies are discussed.

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Vitamin B3 forms as precursors to NAD+: Are they safe?

Poljšak

Milisav

2018

Trends in Food Science & Technology

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Time-Dependent Effects of L-Tryptophan Administration on Urinary Excretion of L-Tryptophan Metabolites

Cited by 13 publications

References 21 publications

Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine

Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine

Biomarkers for In Vivo Assessment of Transporter Function

Vitamin B3 forms as precursors to NAD+: Are they safe?

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