Tuning the swelling and mechanical properties of pH-responsive doubly crosslinked microgels using particle composition

Liu, Ruixue; Milani, Amir H.; Saunders, Jennifer; Freemont, Anthony J.; Saunders, Brian R.

doi:10.1039/c1sm05922j

Cited by 22 publications

(27 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The formation of three-dimensional hydrogels structures based on the assembly of hydrogel colloids have been studied by Saunders et al . 47 48 49 50 51 52 53 , Weitz et al . 44 54 , and other scientists 55 .…”

Section: Resultsmentioning

confidence: 99%

Dual-responsive and Multi-functional Plasmonic Hydrogel Valves and Biomimetic Architectures Formed with Hydrogel and Gold Nanocolloids

Song

Cho

2016

Sci Rep

View full text Add to dashboard Cite

We present a straightforward approach with high moldability for producing dual-responsive and multi-functional plasmonic hydrogel valves and biomimetic architectures that reversibly change volumes and colors in response to temperature and ion variations. Heating of a mixture of hybrid colloids (gold nanoparticles assembled on a hydrogel colloid) and hydrogel colloids rapidly induces (within 30 min) the formation of hydrogel architectures resembling mold shapes (cylinder, fish, butterfly). The biomimetic fish and butterfly display reversible changes in volumes and colors with variations of temperature and ionic conditions in aqueous solutions. The cylindrical plasmonic valves installed in flow tubes rapidly control water flow rate in on-off manner by responding to these stimuli. They also report these changes in terms of their colors. Therefore, the approach presented here might be helpful in developing new class of biomimetic and flow control systems where liquid conditions should be visually notified (e.g., glucose or ion concentration changes).

show abstract

Section: Resultsmentioning

confidence: 99%

Dual-responsive and Multi-functional Plasmonic Hydrogel Valves and Biomimetic Architectures Formed with Hydrogel and Gold Nanocolloids

Song

Cho

2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is well-known that the ringopening reaction of epoxides can occur with carboxylic acid. [35][36][37][38][39][40][41][42][43][44] To date, however, there are no reports on crosslinking between polyacid molecules and PEGDGE for the formation of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Highly compressive and stretchable poly(ethylene glycol) based hydrogels synthesised using pH-responsive nanogels without free-radical chemistry

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…25 In the present study we employed this microgel platform in combination with the model cationic peptide poly-L-lysine (pLys, pI≈9 (10.5 for isolated lysine monomers 12 )). The microgel properties and swelling behaviors with and without incorporated peptide were evaluated by atomic force microscopy (AFM) in Peak Force ® Quantitative Nanomechanical Property Mapping (PF-QNM) mode, while peptide loading and release was monitored by ellipsometry and confocal microscopy.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Peptide Interactions with Surface-Bound Microgels

et al. 2016

Self Cite

View full text Add to dashboard Cite

Effects of electrostatics and peptide size on peptide interactions with surfacebound microgels were investigated with ellipsometry, confocal microscopy, and atomic force microscopy (AFM). Results show that binding of cationic poly-L-lysine (pLys) to anionic, covalently immobilized, poly(ethyl acrylate-co-methacrylic acid) microgels increased with increasing peptide net charge and microgel charge density. Furthermore, peptide release was facilitated by decreasing either microgel or peptide charge density. Analogously, increasing ionic strength facilitated peptide release for short peptides. As a result of peptide binding, the surface-bound microgels displayed pronounced deswelling and increased mechanical rigidity, the latter quantified by quantitative nanomechanical mapping. While short pLys was found to penetrate the entire microgel network and to result in almost complete charge neutralization, larger peptides were partially excluded from the microgel network, forming an outer peptide layer on the microgels. As a result of this difference, microgel flattening was more influenced by the lower Mw peptide than the higher. Peptide-induced deswelling was found to be lower for higher Mw pLys, the latter effect not observed for the corresponding microgels in the dispersed state. While the effects of electrostatics on peptide loading and release were similar to those observed for dispersed microgels, there were thus considerable effects of the underlying surface on peptide-induced microgel deswelling, which need to be considered in the design of surface-bound microgels as carriers of peptide loads, e.g., in drug delivery or in functionalized biomaterials.

show abstract

Tuning the swelling and mechanical properties of pH-responsive doubly crosslinked microgels using particle composition

Cited by 22 publications

References 44 publications

Dual-responsive and Multi-functional Plasmonic Hydrogel Valves and Biomimetic Architectures Formed with Hydrogel and Gold Nanocolloids

Dual-responsive and Multi-functional Plasmonic Hydrogel Valves and Biomimetic Architectures Formed with Hydrogel and Gold Nanocolloids

Highly compressive and stretchable poly(ethylene glycol) based hydrogels synthesised using pH-responsive nanogels without free-radical chemistry

Factors Affecting Peptide Interactions with Surface-Bound Microgels

Contact Info

Product

Resources

About