Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu, Xinkuan; Yang, Yaoyao; Yu, Deng‐Guang; Zhu, Ming; Zhao, Min; Williams, Gareth R.

doi:10.1016/j.cej.2018.09.096

Cited by 136 publications

(96 citation statements)

References 69 publications

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“…Although EHDA processes (including e‐jet printing, electrospraying, and electrospinning) are fast developing to the multiple‐fluids ones, such as coaxial (Hai et al., ; Yu et al., ), triaxial (Liu et al., ; Yang et al., ), their microformation mechanisms are still unclear (Yang, Zhang, Liu, Wang, & Yu, ; Yu, Li, Williams, & Zhao, ). Thus, on one hand, the single‐fluid electrospraying and electrospinning are still the mainstreams of these fabrication methods.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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“…Shown in Figure 2, as the differentiation of traditional processes, it can be anticipated that the modified coaxial process can also differentiated into modified tri-axial process and even tri-layer side-by-side process. Most recently, modified tri-axial electrospinning with only one of the three working fluids having electrospinnability was demonstrated to be very useful in generating high quality core-shell nanofibers [25,26]. What is more, the functional sheath's thickness can be easily manipulated through adjusting the fluid flow rate ratio in a suitable range.…”

Section: The Modified Coaxial Electrospinning With An Unspinnable Shementioning

confidence: 99%

Electrospun Environment Remediation Nanofibers Using Unspinnable Liquids as the Sheath Fluids: A Review

Wang

Yang

et al. 2020

Polymers

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Electrospinning, as a promising platform in multidisciplinary engineering over the past two decades, has overcome major challenges and has achieved remarkable breakthroughs in a wide variety of fields such as energy, environmental, and pharmaceutics. However, as a facile and cost-effective approach, its capability of creating nanofibers is still strongly limited by the numbers of treatable fluids. Most recently, more and more efforts have been spent on the treatments of liquids without electrospinnability using multifluid working processes. These unspinnable liquids, although have no electrospinnability themselves, can be converted into nanofibers when they are electrospun with an electrospinnable fluid. Among all sorts of multifluid electrospinning methods, coaxial electrospinning is the most fundamental one. In this review, the principle of modified coaxial electrospinning, in which unspinnable liquids are explored as the sheath working fluids, is introduced. Meanwhile, several typical examples are summarized, in which electrospun nanofibers aimed for the environment remediation were prepared using the modified coaxial electrospinning. Based on the exploration of unspinnable liquids, the present review opens a way for generating complex functional nanostructures from other kinds of multifluid electrospinning methods.

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“…2). Due to the smaller diameter, high surface area, huge porosity and the typical 3-D web inner structure nanofibers have shown the great potential application in drug delivery [15][16][17][18].…”

Section: Shown Inmentioning

confidence: 99%

The Applications of Advanced Technologies in Dispelling Students Doubts’ about Their Majors

Wang¹,

Pu²,

Guan³

et al. 2019

Proceedings of the 2019 5th International Conference on Social Science and Higher Education (ICSSHE 2019)

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In China, many college students don't know their majors well during choosing them after their successful college entrance examinations. When they go into the college and begin their specialty learning, they are often puzzled by a series of doubts about their discipline knowledge. How to help them to dispel those doubts is very important for them to become senior professional talents in the future. In this paper, an approach is put forward as an alternative method for eliminating the college students' learning doubts about their major. Based on two advanced technologies (electrospinning and electrospraying), some positive teaching materials are refined to dispel the students' doubts and meanwhile increasing their interests about the professional knowledge for those majoring in the specialty of Material Science and Engineering. The strategies exhibited here should be similarly useful for college students majoring in other disciplines.

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Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Cited by 136 publications

References 69 publications

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Electrospun Environment Remediation Nanofibers Using Unspinnable Liquids as the Sheath Fluids: A Review

The Applications of Advanced Technologies in Dispelling Students Doubts’ about Their Majors

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