Tunable ternary nanocomposite prepared by electrodeposition for biosensing of centrally acting reversible acetyl cholinesterase inhibitor donepezil hydrochloride in real samples

Mohamed, Fardous A.; Khashaba, Pakinaz Y.; Shahin, Reem Y.; El-Wekil, Mohamed M.

doi:10.1016/j.colsurfa.2019.01.033

Cited by 28 publications

(14 citation statements)

References 48 publications

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“…The optical properties of quantum dots with UV-Vis and fluorescence spectroscopy were examined. The UV-Vis spectrum was obtained in aqueous solution with the appearance of two bands at 230 nm and 345 nm which correspond to π-π* and n-π* transitions [40,41]. The fluorescence spectrum of VS 2 QDs was presented in Fig.…”

Section: Characterization Of Vs 2 Qdsmentioning

confidence: 99%

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Mahmoud

Alkahtani

El-Wekil

2021

Microchemical Journal

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Characterization Of Vs 2 Qdsmentioning

confidence: 99%

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Mahmoud

Alkahtani

El-Wekil

2021

Microchemical Journal

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“…In some cases, electrodeposition (e.g., AuNPs) and electropolymerization (e.g., polypyrrole [37], and poly(L-methionine [130]) on the PGE surface were achieved in one single step by CV, with other modification procedures comprising both cyclic voltametric and potentiostatic steps [53,91,129,131].…”

Section: Applications Of (Electro)chemically Modified Pges To the Vol...mentioning

confidence: 99%

“…SWV for a PBCG/PGE was successfully applied to pharmacokinetic studies after individual administration of meropenem and ertapenem by monitoring the time-dependent antibiotics levels in healthy rabbit plasma [113]. The pharmacokinetic parameters of donepezil HCl in rabbits' plasma after drug consumption were determined by CV for a PSBT/N-CNDs/CoNPs/PGE by applying a non-compartmental statistics model using moment analysis [131].…”

Section: Pharmacokinetic Studies Performed By Voltammetric Techniques...mentioning

confidence: 99%

Recent Developments in Voltammetric Analysis of Pharmaceuticals Using Disposable Pencil Graphite Electrodes

et al. 2022

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The even growing production of both well-known and new derivatives with pharmaceutical action involves the need for developing facile and reliable methods for the analysis of these compounds. Among the widely used instrumental techniques, the electrochemical ones are probably the simplest and the most rapid, also having good performance characteristics. However, the key tool in electroanalysis is the working electrode. Due to the inherent electrochemical and economic advantages of the pencil graphite electrode (PGE), the interest in its applicability in the analysis of different analytes has continuously increased in recent years. Thus, this paper aims to review the scientific reports published in the last 10 years on the use of the disposable eco- and user-friendly PGEs in the electroanalysis of compounds of pharmaceutical importance in different matrices. The PGE characteristics and designs (bare or modified with various types of materials), along with their applications and performance parameters (e.g., linear range, limit of detection, and reproducibility), will be discussed, and their advantages and limitations will be critically emphasized.

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“…The pharmacokinetic parameters of MeP were estimated using standard non-compartmental methods [113]. The volume of distribution (Vd), mean residence time (MRT), elimination half-life (t 1/2 ), and area under the plasma concentration-time curve from 0 h to infinity (AUC inf ) were determined after intravenous administration of MeP-loaded NPs to animals.…”

Section: In Vivo Pharmacokinetic Studymentioning

confidence: 99%

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva

Yabbarov

Sokół

et al. 2021

IJMS

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The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation. In this study, we applied a two-level three-factor design to optimize the preparation of nanoparticles loaded with cobalt (CoTPP), manganese (MnClTPP), and nickel (NiTPP) metalloporphyrins (MeP). The resulting nanoparticles were examined by dynamic light scattering, X-ray diffraction, Fourier transform infrared spectroscopy, MTT test, and hemolytic activity assay. The optimized model of nanoparticle formulation was validated, and the obtained nanoparticles possessed a spherical shape and physicochemical characteristics enabling them to deliver MeP in cancer cells. In vitro hemolysis assay revealed high safety of the formulated MeP-loaded nanoparticles. The MeP release demonstrated a biphasic profile and release mechanism via Fick diffusion, according to release exponent values. Formulated MeP-loaded nanoparticles revealed significant antitumor activity and ability to generate reactive oxygen species. MnClTPP- and CoTPP-nanoparticles specifically accumulated in tissues, preventing wide tissue distribution caused by long-term circulation of the hydrophobic drug. Our results suggest that MnClTPP- and CoTPP-nanoparticles represent the greatest potential for utilization in in anticancer therapy due to their effectiveness and safety.

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Tunable ternary nanocomposite prepared by electrodeposition for biosensing of centrally acting reversible acetyl cholinesterase inhibitor donepezil hydrochloride in real samples

Cited by 28 publications

References 48 publications

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Recent Developments in Voltammetric Analysis of Pharmaceuticals Using Disposable Pencil Graphite Electrodes

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

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