Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva, Mariia R.; Yabbarov, N. G.; Sokół, Maria; Chirkina, Margarita; Mollaev, M. D.; Zabolotskii, Artur; Серегина, И. Ф.; Bolshov, M.A.; Kaplun, Alexander; Nikolskaya, Elena

doi:10.3390/ijms222212261

Cited by 19 publications

(9 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Surprisingly, PTX PLGA/CD NPs displayed raised t1/2, MRT and AUC compared to Taxol ® , which may indicate rapid tissue distribution of PTX PLGA/CD NPs. Moreover, due to slow PTX release and the high binding constant, the concentration peak of PTX could coincide with a burst release and lead to a prolonged long-term PTX release (Section 3.3) in tissues, since only 80% of PTX was released after 80 h. Probably, the high association of PTX with serum albumin was responsible for the long blood circulation 34 .…”

Section: Resultsmentioning

confidence: 99%

Nanoformulation of Paclitaxel: Exploring the Cyclodextrin / PLGA Nano Delivery Carrier to Slow Down Paclitaxel Release, Enhance Accumulation in Vivo

Ma¹,

Huang²,

Liu³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

Background: Improving the aggregation and penetration in tumor sites increases the anti-tumor efficacy of nanomedicine. In the current study, we designed cyclodextrin modified PLGA nanoparticles loaded with paclitaxel to elevate the accumulation and prolong circulation of chemotherapy drugs in vivo . Methods: The PLGA nanoparticles loaded with paclitaxel (PTX PLGA NPs) and cyclodextrin (CD) modified PLGA nanoparticles loaded with paclitaxel (PTX PLGA/CD NPs) were prepared using the emulsification solvent evaporation method. The nanoparticles were characterized by particle size, zeta potential, encapsulation efficiency, infrared spectroscopy analysis and X-Ray diffraction (XRD). Then, drug release of the nanoparticles was evaluated via reverse dialysis method in vitro . Finally, the in vivo distribution fate and pharmacokinetic characteristics of the nanoparticles were assessed in mice and rats. Results: The average particle size, zeta potential, and encapsulation efficiency of PTX PLGA NPs were (163.57±2.07) nm, - (20.53±2.79) mV and (60.44±6.80)%. The average particle size, zeta potential, and encapsulation efficiency of PTX PLGA/CD NPs were (148.57±1.66) nm, - (11.42±0.84) mV and (85.70±2.06)%. In vitro release studies showed that PTX PLGA/CD NPs were released more slowly compared to PTX PLGA NPs under normal blood pH conditions, while PTX PLGA/CD NPs were released more completely under tumor site pH conditions. The modified PLGA nanocarrier (PLGA/CD NPs) increased drug residence time and accumulation than the plain PLGA nanocarrier (PLGA NPs) in vivo distribution. In addition, the elimination half-life, area under the drug-time curve, and maximum blood concentration of the nanoparticle group were higher than those of Taxol ® , especially the PTX PLGA/CD NPs group, which was significantly different from Taxol ® and plain nanoparticle groups ( p <0.001). Conclusions: The 2-HP-β-CD modified PLGA nanoparticles prolonged circulation time and accumulation of the chemotherapy drug paclitaxel in vivo .

show abstract

Section: Resultsmentioning

confidence: 99%

Nanoformulation of Paclitaxel: Exploring the Cyclodextrin / PLGA Nano Delivery Carrier to Slow Down Paclitaxel Release, Enhance Accumulation in Vivo

Ma¹,

Huang²,

Liu³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

show abstract

“…A specific drug loaded with PLGA nanoparticles using the single emulsion–solvent evaporation method possessed high drug loading content, encapsulation efficiency, and a small size, and negative surface charge contributed to a specific intracellular accumulation [ 26 ]. Previous results also suggest that PLGA nanoparticles represent a high potential for utilization in anticancer therapy due to their effectiveness and safety [ 27 ]. PLGA nanoparticles loaded with miR-30b-5p can improve cardiac function, attenuate myocardial injury, and regulate the expression of factors associated with cardiac hypertrophy and inflammation by targeting TGFBR2 [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats

Chung

Cheng

et al. 2022

JPM

View full text Add to dashboard Cite

Exendin-4 (Ex-4) is an incretin mimetic agent approved for diabetes treatment and neuronal protection. However, the required frequent injections restrict its clinical application. We prepared Ex-4-loaded poly(d,l-lactide-co-glycolide) nanoparticles (PEx-4) and investigated their effect on cerebral ischemia/reperfusion (IR) injury associated with micturition center damage-induced cystopathy in diabetic rats. Using ten minutes of bilateral carotid artery occlusion combined with hemorrhage-induced hypotension of the IR model in streptozotocin-induced type 1 diabetic (T1DM) Wistar rats, we compared the effects of Ex-4 and PEx-4 on prefrontal cortex edema, voiding function and oxidative stress including cerebral spinal fluid (CSF) reference H2O2 (RH2O2) and HOCl (RHOCl) levels, endoplasmic reticulum (ER) stress, apoptosis, autophagy and pyroptosis signaling in brain and bladder by Western blot and immunohistochemistry. Single injection of PEx-4 displayed higher CSF antioxidant activity and a long-lasting hypoglycemic effect compared to Ex-4 in rats. T1DM and IR primarily enhanced CSF RH2O2, and pIRE-1/caspase-12/pJNK/CHOP-mediated ER stress, caspase-3/PARP-mediated apoptosis, Beclin-1/LC3B-mediated autophagy and caspase-1/IL-1β-mediated pyroptosis signaling in the damaged brains. Our data further evidenced that PEx-4 were more efficient than Ex-4 in attenuating IR-evoked prefrontal cortex edema, the impairment in micturition center and the enhanced level of CSF RH2O2 and HOCl, ER stress, apoptosis, autophagy and pyroptosis parameters in the damaged brains, but had less of an effect on IR-induced voiding dysfunction in bladders of T1DM rats. In summary, PEx-4 with stronger antioxidant activity and long-lasting bioavailability may efficiently confer therapeutic efficacy to ameliorate IR-evoked brain damage through the inhibitory action on oxidative stress, ER stress, apoptosis, autophagy and pyroptosis signaling in diabetic rats.

show abstract

“…Hemolytic activity was determined by the method of Mollaeva MR et al [13]. Rat blood (5 mL) was used for the experiment.…”

Section: Hemolysis Assay For Honey-based Znonpsmentioning

confidence: 99%

Antibacterial and photocatalytic effects of newly synthesized zinc oxide nanoparticles derived from Mongolian honey

Lkhagvadorj,

Batsukh,

Tsend-Ayush

2024

Mong. J. Chem.

View full text Add to dashboard Cite

Development of bio-compatible, bio-safe and environmentally friendly nanoparticles is a matter of urgency for research in the field of nanotechnology. In this study, we aimed to prepare zinc oxide nanoparticles from Mongolian honey as raw material and to determine its biological activities. Honey-based zinc oxide nanoparticles were obtained by green synthesis method, and their characteristics and biological activities were evaluated. Developed zinc oxide nanoparticles from Khentii honey and Selenge honey were at a size of 16.02 nm and 95.23 nm, respectively. A characteristic band of Khentii honey-based zinc oxide nanoparticles was observed at 466 cm–1 and a band of Selenge honey-based zinc oxide nanoparticles was also observed at 434 cm–1. Antibacterial and photocatalytic effects were detected for the developed nanoparticles. The study suggested that newly synthesized honey-based zinc oxide nanoparticles might be an effective tool against bacterial infection.

show abstract

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Cited by 19 publications

References 109 publications

Nanoformulation of Paclitaxel: Exploring the Cyclodextrin / PLGA Nano Delivery Carrier to Slow Down Paclitaxel Release, Enhance Accumulation in Vivo

Nanoformulation of Paclitaxel: Exploring the Cyclodextrin / PLGA Nano Delivery Carrier to Slow Down Paclitaxel Release, Enhance Accumulation in Vivo

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats

Antibacterial and photocatalytic effects of newly synthesized zinc oxide nanoparticles derived from Mongolian honey

Contact Info

Product

Resources

About