Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Mahmoud, Ashraf M.; Alkahtani, A. Saad; El-Wekil, Mohamed M.

doi:10.1016/j.microc.2021.105925

Cited by 38 publications

(21 citation statements)

References 48 publications

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“…From this calculation, it was found that two electrons were involved in the HCQ oxidation under acidic pH conditions ( Figure 3 ). In fact, the value of E° confirms the results reported by Mahnashi et al [ 40 ], Decoro et al [ 31 ], Khoobi et al [ 41 ], and Arguelho et al [ 11 ] which have suggested that the electrooxidation of HCQ involved the nitrogen atom of the alkylamino side chain and the N-heterocyclic nitrogen of the aminoquinoline moiety of hydroxychloroquine, respectively ( Figure 3 ). E° was obtained from the slope of E pa versus ln v (assuming α = 0.5).…”

Section: Resultssupporting

confidence: 89%

Green Composite Sensor for Monitoring Hydroxychloroquine in Different Water Matrix

et al. 2021

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Hydroxychloroquine (HCQ), a derivative of 4-aminoquinolone, is prescribed as an antimalarial prevention drug and to treat diseases such as rheumatoid arthritis, and systemic lupus erythematosus. Recently, Coronavirus (COVID-19) treatment was authorized by national and international medical organizations by chloroquine and hydroxychloroquine in certain hospitalized patients. However, it is considered as an unproven hypothesis for treating COVID-19 which even itself must be investigated. Consequently, the high risk of natural water contamination due to the large production and utilization of HCQ is a key issue to overcome urgently. In fact, in Brazil, the COVID-19 kit (hydroxychloroquine and/or ivermectin) has been indicated as pre-treatment, and consequently, several people have used these drugs, for longer periods, converting them in emerging water pollutants when these are excreted and released to aquatic environments. For this reason, the development of tools for monitoring HCQ concentration in water and the treatment of polluted effluents is needed to minimize its hazardous effects. Then, in this study, an electrochemical measuring device for its environmental application on HCQ control was developed. A raw cork–graphite electrochemical sensor was prepared and a simple differential pulse voltammetric (DPV) method was used for the quantitative determination of HCQ. Results indicated that the electrochemical device exhibited a clear current response, allowing one to quantify the analyte in the 5–65 µM range. The effectiveness of the electrochemical sensor was tested in different water matrices (in synthetic and real) and lower HCQ concentrations were detected. When comparing electrochemical determinations and spectrophotometric measurements, no significant differences were observed (mean accuracy 3.0%), highlighting the potential use of this sensor in different environmental applications.

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Section: Resultssupporting

confidence: 89%

Green Composite Sensor for Monitoring Hydroxychloroquine in Different Water Matrix

et al. 2021

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“…The literature does not clearly report the nature of the two oxidation peaks presented. Several studies [8,13,17,18,38,39] show that the oxidation reaction of HCQ is pH-dependent. This fact makes possible some assumptions about the process from what is informed, based on the pKa values of the functional groups of the HCQ molecule.…”

Section: Electrochemical Performance Of Cnns/ementioning

confidence: 99%

“…Electrochemical sensors can be manufactured by using several materials, and in some cases, taking many steps through the synthesis of modifiers [17,18]. However, carbon paste stands out due to its ease of production, modification, and assembly on the electrode.…”

Section: Introductionmentioning

confidence: 99%

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Silva

Sant’Anna

Gevaerd³

et al. 2021

Electroanalysis

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This study introduces modified carbon paste electrodes with carbon nitride nanosheets (CNNS) and outlines their application for the determination of hydroxychloroquine sulfate (HCQ) in tablets and synthetic urine samples. CNNS were synthesized by hydrothermal route (200°C, 10 h) using melamine and citric acid as their precursors. The carbon nitride nanosheets-based electrode (CNNS/E) presented a linear dynamic range for HCQ (LDR), ranging from 10.0 nmol l À 1 to 6.92 μmol l À 1 , and detection (LOD) and quantification limits (LOQ) of 0.16 nmol l À 1 and 0.52 nmol l À 1 , respectively. LOD and LOQ were calculated by the equations: LOD = 3(S d /b), and LOQ = 10(S d /b). The modified sensor presented excellent relative standard deviations for parameters such as repeatability (2.39 % and 1.87 %) and reproducibility (3.22 % and 2.32 %) in HCQ oxidation peaks (1 and 2). The CNNS/E has not shown significant variations in its anodic signal intensity in the presence of some organic and inorganic substances. It is worth bearing in mind that CNNS/E can be easily manufactured and the sensor has the lowest HCQ detection limits reported so far. The proposed sensor was successfully applied for HCQ determination in tablets and synthetic urine, showing good recovery values and an error of 0.60 % about comparative method in tablet samples, assuring the quality of the method.

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“…Thus, it is vital to construct selective, sensitive, and cost-effective sensors to detect S. aureus . Electroanalytical techniques have drawn great attentions as a result of fast response, sufficient selectivity, low detection limits, simplicity, and low cost 6 – 12 .…”

Section: Introductionmentioning

confidence: 99%

An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au/Fe3O4 binary hybrid

El-Wekil

Halby

Darweesh

et al. 2022

Sci Rep

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Pathogenic bacteria cause disease outbreaks and threaten human health, prompting the research on advanced detection assays. Herein, we developed a selective molecular imprinted aptasensor for sensitive and prompt quantitation of Staphylococcus aureus (S. aureus) bacteria. The aptasensor was constructed by immobilization of aptamer on gold nanoparticles modified magnetic nanoparticles (apt-AuNPs@ Fe3O4). A functional monomer (o-phenylenediamine, o-phen) was electro-polymerized on the surface of the as-synthesized nanocomposite in the presence of a template (S. aureus). After removing S. aureus, the formed imprinted sites were available to extract pathogenic bacteria from complicated matrices. The surface morphology of the as-fabricated nanocomposites was characterized using different spectroscopic and electrochemical methods. Moreover, we thoroughly evaluated factors affecting the synthesis and determination procedures. The molecular imprinted aptasensor exhibited a wide linear range of 101–107 CFU mL−1 with a Limit of Detection, LOD (signal to noise = 3) of 1 CFU mL−1. The aptasensor detected S. aureus in milk, conduit water, and apple juice samples with good recoveries % and satisfactory relative standard deviations (RSDs %) values.

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Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Cited by 38 publications

References 48 publications

Green Composite Sensor for Monitoring Hydroxychloroquine in Different Water Matrix

Green Composite Sensor for Monitoring Hydroxychloroquine in Different Water Matrix

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au/Fe3O4 binary hybrid

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