Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Li, Chen; Wang, Zhuanhua; Yu, Deng‐Guang; Williams, Gareth R.

doi:10.1186/1556-276x-9-258

Cited by 55 publications

(31 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this traditional concept about coaxial electrospinning has viewed the sheath fluid as a dominant factor during the treatment process. But the core fluid can also acts as a dominant role during the spinning process and led the sheath fluid to act together for a smooth coaxial process and also for a new core-sheath nanostructure [19][20][21][22][23][24]. Thus as shown in Fig.…”

Section: From Traditional Coaxial Electrospinning To Modified Coaxialmentioning

confidence: 99%

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Xiu¹,

Liu²,

Tan³

et al. 2017

dtssehs

Self Cite

View full text Add to dashboard Cite

Abstract. In higher education, the cultivation of innovation ability is very important for the college students. However, how to train innovative thinking is often a big concern for their teachers. In this paper, a simple way is shown, which is about how to guide the students to learn and to think about the evolution of a series of material processing technologies. With the integration of concepts from traditional wet spinning process with those from the single-fluid electrospinning, the modified coaxial electrospinning was hatched out from the traditional coaxial one. This evolution process comprises an excellent example to explain to the college students majoring in Materials Science and Engineering about engineering innovation. The thinking and explaining paradigm manifested in this example not only will be useful for the students to grasp new advanced technologies, promote them to do practical innovations, but also should be very useful for a wide variety of engineering disciplines to effectively take innovative engineering educations.

show abstract

Section: From Traditional Coaxial Electrospinning To Modified Coaxialmentioning

confidence: 99%

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Xiu¹,

Liu²,

Tan³

et al. 2017

dtssehs

Self Cite

View full text Add to dashboard Cite

show abstract

“…The produced fibers often have a diameter at the macro-scale [6,7]. The electrospraying process is a relatively simple process, just as the popular electrospinning process [8][9][10][11][12][13][14][15][16][17]. A diagram is shown in Fig.…”

Section: Electrosprayingmentioning

confidence: 99%

From Mechanical Spraying to Electrospraying-Advanced Technology Teaching in Higher Education

Wu¹,

Han-fang²,

Ma³

et al. 2017

Proceedings of the 2017 International Conference on Management, Education and Social Science (ICMESS 2017)

View full text Add to dashboard Cite

Abstract-It is important to explain the advanced nanotechnology to the college students in higher education for training their creativity and arousing their learning interests. In this paper, a new method was developed for teaching the new technology in a vivid manner. The results demonstrated that an analogical comparison between a traditional technique and an advanced one not only can effectively promote the students to understand the new one, but also can be used as a useful tool to encourage the student to do more self-learning about material science and engineering in higher education. With electrospraying as a technique model, the difficulties in clear explanations this complicated new process in the class could be easily overcome by the usage of traditional spraying as a start point. Based on their past knowledge and experience about the spraying processes, the college students majoring in material engineering were able to quickly grasp the essences of electrospraying, discriminated the differences between electrospraying and spraying. Some students eagerly went to the experimental laboratory to carry out some experiments about the preparations and characterizations of electrosprayed protein microparticles.

show abstract

“…If the fibers are appropriately designed, core-shell drug-loaded fibers can additionally eliminate the initial burst release commonly seen with monolithic fibers, resulting in zero-order release materials or multiple-phase controlled release. 21,22 The simultaneous release of multiple drugs is also possible, 23,24 and a wider range of polymers can be processed with the coaxial approach than with single-fluid spinning. 25 Given that multiple drugs can be incorporated into coaxial electrospun fibers and released into particular parts of the body, here we aimed to fabricate a series of novel theranostic systems using this process.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Jin

Geraldes

et al. 2016

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Abstract:New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnostic and targeting agents are much sought after. This work reports for the first time the use of coaxial electrospinning to prepare such systems in the form of core-shell fibers. Eudragit S100 was used to form the shell of the fibers, while the core comprised polyethylene oxide loaded with the magnetic resonance contrast agent Gd(DTPA) (Gd(III) diethylenetriaminepentaacetate hydrate) and indomethacin as a model therapeutic agent. The fibers had linear cylindrical morphologies with clear core-shell structures, as demonstrated by electron microscopy. X-ray diffraction and differential scanning calorimetry proved that both indomethacin and Gd(DTPA) were present in the fibers in the amorphous physical form. This is thought to be a result of intermolecular interactions between the different components, the presence of which was suggested by IR spectroscopy. In vitro dissolution tests indicated that the fibers could provide targeted release of the active ingredients through a combined mechanism of erosion and diffusion. The proton relaxivities for Gd(DTPA) released from the fibers into tris buffer increased (r 1 =5.03-10.13 s -1 mM -1 ; r 2 =8.28-14.96 s -1 mM -1 ) compared with fresh Gd(DTPA) (r 1 =4.37 s -1 mM -1 and r 2 =4.85 s -1 mM -1 ), proving that electrospinning has not diminished the contrast properties of the complex. The new systems reported herein thus offer a new platform for delivering therapeutic and imaging agents simultaneously to the colon.

show abstract

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Cited by 55 publications

References 28 publications

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

From Mechanical Spraying to Electrospraying-Advanced Technology Teaching in Higher Education

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Contact Info

Product

Resources

About