Tumour Site: A Prognostic Factor in Colorectal Cancer?: A Multivariate Analysis

Abstract

Data from 753 patients with single adenocarcinomas of the large intestine diagnosed and treated at Trondheim Regional and University Hospital between 1964 and 1978 were studied to determine the influence of tumour site on survival by adjusting for tumour stage, age, and sex. The Cox regression model was used. Although the clinicopathologic stage had the strongest association with prognosis, the tumour site independently influenced the mortality, which increased from the right colon via the transverse/left part of the colon to the rectum.

Colorectal Cancer in Jordan: Survival Rate and Its Related Factors

“…This finding is consistent with findings of many other studies [23, 26, 28]. The Thailand study showed that the 5-year stage specific survival rates for stages I, II, III, and IV CRC were 100%, 68%, 44%, and 2%, respectively [29].…”

“…Different clinical and pathological prognostic factors have been proposed for CRC in the literature, including location of the tumor [13, 16, 24, 25], tumor stage [26], differentiation of tumor [13], and surgical and distant metastasis [23]. The multivariate analysis using Cox-regression analysis showed that grade and stage were significant predictors of survival.…”

Tumour location is a prognostic factor for survival in colonic cancer patients

“…In the present study, there was no such difference, neither was there in a national review of colorectal cancer from Norway [17], nor in other studies [4,[27][28]. However, reduced survival in left colon cancer compared to right colon cancer was reported in a Norwegian study from 1987 [29] and Aldrige et al reported similar results [30].…”

An overview of colorectal cancer survival rates and prognosis in Asia

“…From initial diagnosis through definitive treatment, pathological assessment of a resected colorectal cancer is still considered the most accurate method of assessing the tumorrelated features that determine postoperative outcome. Different clinico-pathological prognostic factors have been proposed: location of the tumor [21,22,26,27,35,38] , depth of tumor invasion [32,37,40] , tumor stage [32,47] , differentiation of tumor [20,21,48] , surgical procedure [15,25] , pathological type [25,48] , tumor size [21,[48][49][50] , lymph node metastasis [21,51,52] and distant metastasis [15,25,48] . The site of the tumor has been investigated as a possible prognostic factor.…”