An overview of colorectal cancer survival rates and prognosis in Asia

Moghimi-Dehkordi, Bijan; Safaee, Azadeh

doi:10.4251/wjgo.v4.i4.71

Cited by 156 publications

(119 citation statements)

References 43 publications

(68 reference statements)

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“…According on World Health Organization (WHO) reports, CRC is one of the common diseases in an Asian population (Moghimi-Dehkordi et al, 2012;Haerian et al, 2014). It is noticeable that incidence of this cancer has been rising in an Iranian population during recent decades (Azadeh et al, 2007;Milanizadeh et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Akbari

Safari-Alighiarloo²,

Haghighi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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SMAD7 has been identified as a functional candidate gene for colorectal cancer (CRC). SMAD7 protein is a known antagonist of the transforming growth factor beta (TGF-b) signaling pathway which is involved in tumorigenesis. Polymorphisms in SMAD7 may thus alter cancer risk. The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological features in an Iranian population. In total, 210 subjects including 105 patients with colorectal cancer and 105 healthy controls were recruited in our study. All samples were genotyped by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of colorectal cancer and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs2337107and the risk of colorectal cancer. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). Although there was not any association between genotypes and disorder, CT was the most common genotype in this population. This genotype prevalence was also higher in the patients with well grade (54.9%) and colon (72.0%) tumors. Our results provide the first evidence that this polymorphism is not a potential contributor to the risk of colorectal cancer and clinicopathological features in an Iranian population, and suggests the need of a large-scale case-control study to validate our results.

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Section: Introductionmentioning

confidence: 99%

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Akbari

Safari-Alighiarloo²,

Haghighi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…9 Laparoscopic primary closure of the common bile duct without a T-Tube has been advocated by some authors because of the potential complications associated with T-tube placement. [10][11][12][13][14] In the Petelin JB, Lechleitner RA, series, primary closure of the choledochotomy laparoscopically was performed in over one third of cases where a choledochotomy was used, and did not result in any complications. 15 There was no incidence of bile leak, peritonitis, or clinical evidence of retained bile duct stones.…”

Section: Discussionmentioning

confidence: 99%

Primary closure versus T-tube drainage after laparoscopic choledocholithotomy: a prospective randomized study

et al. 2017

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Background: Traditionally laparoscopic common bile duct exploration is followed by T-tube placement because of which patients suffer problems related to T-tube thereby increasing the morbidity of patients. Primary closure of CBD following laparoscopic choledocholithotomy is now being considered as an alternative superior to the traditional method. This study is designed to analyse the outcome of primary CBD repair in terms of mean operation time, duration of hospital stay and post-operative morbidity.Methods: A prospective randomized study was done in which 40 patients at our institute and associated hospitals were divided into two groups to compare the results of primary closure to T-tube placement following laparoscopic choledocholithotomy.Results: 40 patients were included in this study. The mean operating time was observed to be 65±14.05 mins in Group A (primary closure) patients while that in case of Group B (T-tube drainage) patients was 95.25±9.66 mins with a p-value 0.0001 which is considered statistically significant. The average duration of hospital stay in Group A (primary closure) was 8.2 days which was much shorter than that of Group B (T-tube drainage) patients which was of 15.7 days. The post-operative complication was observed in 1 patient of Group A (primary closure) while post-operative complication occurred in 3 patients of Group B (T-tube drainage).Conclusions: This study indicates that primary repair following laparoscopic choledocholithotomy is a safer and more effective method than T-tube drainage and we strongly recommend this procedure in clinical practice.

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“…Right colon cancer has good long term survival, with the overall survival being as high as 64%. 6 However, the reported 5-year survival in India has been poor, even with early colon cancers, when compared to other Asian countries and the West 7,8 . This paper analyses the demographics and outcomes of surgically treated right colon cancer over a 9-year period at a colorectal unit in a tertiary care referral teaching center in South India.…”

Section: Introductionmentioning

confidence: 99%

Demographics and outcomes of surgically treated right sided colon cancer in India: a 9-year single institution experience

Franklyn¹

2016

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Background: There is sparse Indian data on right colon cancer. Available literature suggests that it affects the young and survival is poor. Aim: This article reviews demographics and outcomes of surgically treated right sided colon cancer over a nine year period in a single colorectal unit in a tertiary care teaching hospital. Methods: A retrospective review of all patients undergoing right hemicolectomy for adenocarcinoma of the colon between January 2004 and December 2012 was undertaken. Data was collected from hospital records and telephonic interview when possible. Results: Two hundred and thirteen patients were studied. Mean age was 49 years with 57.1% being 50 years or younger. Stage 1 disease was seen in 9.9%, stage 2 in 35.2%, stage 3 in 42.3%, and stage 4 in 12.7%. Follow up was available for 81.6% with a mean follow up of 35.6 months. Five year disease free survival (DFS) and overall survival (OS) was 81% and 74%. Presence of lymphovascular invasion and age >50 years were predictors of poor survival. Poor prognostic features on histopathology were not different between the young and the old. The 5 year DFS was similar in both, but the 5 year OS was better for the young (90% vs. 73%, p=0.029) Conclusions: Patients with right colon cancer are younger in India. They have similar histopathology when compared to the older population. Operable right colon cancer has an excellent prognosis. Five year DFS is similar in the young and the old, but OS is lower in the older population.

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An overview of colorectal cancer survival rates and prognosis in Asia

Cited by 156 publications

References 43 publications

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Lack of Influence of the SMAD7 Gene rs2337107 Polymorphism on Risk of Colorectal Cancer in an Iranian Population

Primary closure versus T-tube drainage after laparoscopic choledocholithotomy: a prospective randomized study

Demographics and outcomes of surgically treated right sided colon cancer in India: a 9-year single institution experience

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