Tumors of smooth-muscle origin in HIV-infected children

Eg, Chadwick; E, Connor; Hanson, Icg; Vv, Joshi; Abu-Farsakh, Hussam; Yogev, Ram; McSherry, George; McClain, Kenneth L.; Murphy, S C

doi:10.1016/0020-7292(91)90615-c

Cited by 11 publications

(13 citation statements)

References 10 publications

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“…Smooth muscle tumors in children with HIV have a predilection for the GI tract and lungs, sites which are rare among HIV-negative children. We are aware of only one previous case of an appendiceal LMS reported in a child with HIV, however it was found in a patient with 40 LMS peppered throughout the GI tract from stomach to rectum with metastatic disease in the lungs and brain [3]. To our knowledge there have been no reports of solitary appendiceal LM among HIV infected children.…”

Section: Discussionmentioning

confidence: 84%

“…In the general pediatric population, the annual incidence of soft tissue tumors is 8.4 cases per million, of which rhabdomyosarcomas account for more than 70% and smooth muscle tumors account for less than 2% [2]. In 1990, an association was first made between pediatric HIV infection and an increased incidence of smooth muscle tumors [3]. Currently LMS and LM are recognized as the second most frequent type of malignancy among children with HIV, accounting for approximately 17% of cases [4,5].…”

Section: Discussionmentioning

confidence: 98%

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An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome

et al. 2006

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Children with acquired immunodeficiency syndrome (AIDS) are at an increased risk for lymphoproliferative and neoplastic disorders. Included among these are smooth muscle neoplasms such as leiomyomas and leiomyosarcomas. There have been at least 15 reported cases of smooth muscle tumors in the approximately 8,000 children with AIDS, however the incidence in immunocompetent children is only two per ten million. The lesions in children with human immunodeficiency virus infection are usually found in the lung, liver, and gastrointestinal tract. Here, we present an unusual case of a 12-year-old African American girl with vertically acquired AIDS who presented to the pediatric emergency department with severe diffuse abdominal pain. She was ultimately found to have an appendiceal leiomyoma on abdominal exploration, the first reported case. Our report suggests that smooth muscle tumors of the appendix be included in the differential diagnosis of abdominal masses in children with AIDS.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 98%

An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome

et al. 2006

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“…The remainder represents a combination of children whose tumours were benign or in a few cases malignant [4][5][6]. These tumours were reported to be in the stomach, duodenum, ileum and colon, most occurring above the age of 10 years.…”

Section: Discussionmentioning

confidence: 96%

Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

Towu

Stanton

2006

Ped Surgery Int

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Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.

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“…Most GISTs also occur in adults; however, a few cases have been recorded in infants and children, but most of them were reported in patients with certain background conditions, such as von Recklinghausen's disease 11,12 or HIV infection. 13 However, our 4-year-old patient did not have any associated disease (including von Recklinghausen's disease and HIV infection).…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological features of colonic stromal tumor in a child

et al. 2000

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Neoplasms of the colonic submucosa are rare in children. Gastrointestinal stromal tumors (GISTs) are undifferentiated tumors, usually diagnosed by immunohistochemistry. We report a 4-year-old girl with a submucosal GIST of the ascending colon, which was detected by computed tomography. Diagnosis after ileocecal resection was established by histology. In addition, sections were examined immunohistochemically, using antibodies against vimentin, desmin, alpha-smooth muscle actin, S100, neuron-specific enolase, c-kit, and CD34. Hematoxylin and eosin-stained sections showed interlacing fascicles with occasional palisades of epithelioid and spindle cells. The tumor cells were positive for vimentin and CD34. To our knowledge, this is the first reported case of colonic stromal tumor in a child.

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Tumors of smooth-muscle origin in HIV-infected children

Cited by 11 publications

References 10 publications

An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome

An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome

Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology

Clinical and histopathological features of colonic stromal tumor in a child

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