Clinical and histopathological features of colonic stromal tumor in a child

Abstract

Neoplasms of the colonic submucosa are rare in children. Gastrointestinal stromal tumors (GISTs) are undifferentiated tumors, usually diagnosed by immunohistochemistry. We report a 4-year-old girl with a submucosal GIST of the ascending colon, which was detected by computed tomography. Diagnosis after ileocecal resection was established by histology. In addition, sections were examined immunohistochemically, using antibodies against vimentin, desmin, alpha-smooth muscle actin, S100, neuron-specific enolase, c-kit, and CD34. Hematoxylin and eosin-stained sections showed interlacing fascicles with occasional palisades of epithelioid and spindle cells. The tumor cells were positive for vimentin and CD34. To our knowledge, this is the first reported case of colonic stromal tumor in a child.

Gastrointestinal stromal tumor in a child and review of the literature

“…Only 25 children less than 15 years old including our case have been reported in the literature in English [3,4,[6][7][8][9][10][11][12][13][14][15][16]. Table 1 summarizes the clinical characteristics and compares GIST in adults and children.…”

Gastrointestinal stromal tumors arising from the stomach: A report of three children

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] When reviewing the published cases along with our series, we have identified important differences when compared with the adult literature that may be important for clinicians who treat children.…”

Neonatal gastrointestinal stromal tumor. Report of a case and review of literature

“…Majority of the cases are in adults and there are very few reports in children [6][7][8][9][10]. The most common location in this age group is in the stomach, and they are very rare in the colon [8].…”

“…The most common nonepithelial tumors of the intestine are GISTs [8]. Majority of the cases are in adults and there are very few reports in children [6][7][8][9][10].…”

“…The most common location of these tumors is in the stomach [5]. Majority of the patients are middle-aged, and there are only rare case reports in children [6][7][8], but until now there are a few reported colonic GIST tumors in the neonatal period. So, in this report, we will discuss a very rare case of neonatal GIST and its clinical, histopathological, and prognostic findings.…”