Tumormarker bei gastrointestinalen Erkrankungen

Wolter, C.; Neumeier, D.

doi:10.1007/3-540-30036-8_12

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…CA19-9 serum concentrations > 1000 U/ml indicate most likely malignant tumors. In the case of CEA a malignant tumor is most likely if serum levels are four times higher than the reference serum value of 3.6 ng/ml at our institution [ 21 ]. Complete resection of hilar cholangiocarcinoma plus additional liver resection with hilar lymph node dissection offers the only curative treatment.…”

Section: Introductionmentioning

confidence: 99%

Tumor markers as a diagnostic key for hilar Cholangiocarcinoma

Juntermanns¹,

Radünz²,

Heuer³

et al. 2010

Eur J Med Res

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ObjectiveHilar cholangiocarcinoma is the fourth most common gastrointestinal malignancy. CA19-9 and CEA are helpful devices in the management of gastrointestinal malignancies and belong to clinical routine in surgical oncology. But the validity of these parameters in terms of tumor extension and prognosis of bile duct malignancies still remains unclear.MethodsFrom 1998 to 2008, we obtained preoperative CA19-9 and CEA serum levels in 136 patients with hilar cholangiocarcinoma. We correlated tumor stage, resectability rate and survival with preoperative CA 19-9 and CEA serum levels.ResultsCA19-9 (UICC I: 253 ± 561 U/ml; UICC II: 742 ± 1572 U/ml; UICC III: 906 ± 1708 U/ml; UICC IV: 1707 ± 3053 U/ml) and CEA levels (UICC I: 2.9 ± 3.8 U/ml; UICC II: 4.6 ± 6.5 U/ml; UICC III: 18.1 ± 29.6 U/ml; UICC IV: 22.7 ± 53.9 U/ml) increase significantly with rising tumor stage. Patients with pre operative serum levels of CA19-9 (> 1000 U/ml) and CEA (> 14.4 ng/ml) showed a significant poorer resectability rate and survival than patients with lower CA19-9 and CEA serum levels respectively.ConclusionCA19-9 and CEA serum levels are associated with the tumor stage. If preoperatively obtained CA19-9 and CEA serum levels are highly elevated patients have an even worse survival and the frequency of irresectability is significantly higher.

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Section: Introductionmentioning

confidence: 99%

Tumor markers as a diagnostic key for hilar Cholangiocarcinoma

Juntermanns¹,

Radünz²,

Heuer³

et al. 2010

Eur J Med Res

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show abstract

“…No consensus has yet been reached regarding the test frequency or magnitude or the kinetics of change that are likely to be significant, and over what period such a change must be maintained to be significant [15,22]. This is due to limited knowledge on the half-life of CA 19-9, among other reasons [15].…”

Section: Discussionmentioning

confidence: 99%

“…Estimation of the treatment result was performed by calculating the NP concentration without prior inherited "waste" concentrations. According to the literature [7,[18][19][20][21][22] the biological half-life of CA 19-9 was assumed to be 4-8 days to calculate its biological decay. The amount of decay and NP levels were computed from the resulting values of each CA 19-9 probe by subtracting the calculated amount of biological decay of the previously determined CA 19-9 serum levels from the actual determined CA 19-9 concentrations.…”

Section: Methodsmentioning

confidence: 99%