CA19-9 beim intrahepatischen Cholangiokarzinom

Juntermanns, Benjamin; Kaiser, Gernot; Gutierrez, Sylvia; Heuer, Matthias; Buechter, Matthias; Kahraman, Alişan; Reis, Henning; Kasper, Stefan; Paul, Andreas; Fingas, Christian D.

doi:10.1007/s00104-018-0636-z

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…As we all know, the content of serum tumor markers will change with the continuous development of the disease. The detection of serum tumor markers helps to detect abnormalities in the body as soon as possible and improve the early diagnosis rate of tumors [ 26 ]. AFP and CA199 are commonly used tumor markers for the diagnosis of liver cancer.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Kong

Jiang²,

Sun

et al. 2022

Journal of Healthcare Engineering

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Background. Early screening and diagnosis are of great significance to the treatment and prognosis of patients with liver cancer. This study aims to explore the application value of contrast-enhanced ultrasound and enhanced CT combined with tumor markers alpha-fetoprotein (AFP) and carbohydrate antigen 199 (CA199) in the diagnosis of liver cancer. Methods. Liver cancer group (n = 256), benign disease group (n = 110), and control group (n = 50) participated in this study. The liver cancer and benign disease groups were diagnosed pathologically by contrast-enhanced ultrasound and enhanced CT before operation. The electrochemiluminescence method was used to detect the content of AFP and CA199. And the receiver operating characteristic (ROC) curve was drawn. Results. The detection rate of contrast-enhanced ultrasound is higher than that of enhanced CT. Serum levels of AFP and CA199 in the liver cancer group were significantly higher than those in the benign lesion group and the control group. The ROC curve showed that the sensitivity, accuracy, and negative prediction rate of contrast-enhanced ultrasound and enhanced CT combined with tumor markers AFP and CA199 in the diagnosis of liver cancer were significantly higher than that of a single test. Conclusion. The combined detection of contrast-enhanced ultrasound and enhanced CT, AFP, and CA199 significantly improved the sensitivity and accuracy of liver cancer diagnosis. It has a significant effect on the early diagnosis of liver cancer and can be used as an important means of early screening.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Kong

Jiang²,

Sun

et al. 2022

Journal of Healthcare Engineering

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“…Domestic studies suggest that elevated CA19-9 can be used as an independent factor in cholangiocarcinoma, but most studies are based on operable patients. [7,[30][31][32][33][34] Domestic scholars believe that the survival rate of preoperative CA19-9 level < 150 U/mL is significantly better than that of patients with high CA19-9 level. [35] Heimbach et al [36] found that CA 19-9 > 100 U/mL can be used as a predictor of recurrence in liver transplant patients by performing orthotopic liver transplantation in 65 patients with HCCA who cannot undergo surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Prognostic influence for hilar cholangiocarcinoma and comparisons of prognostic values of Mayo staging and TNM staging systems

Sun

Guo

et al. 2022

Medicine

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The study was designed to discuss the effect of stratification factors in the Mayo staging on the prognosis of hilar cholangiocarcinoma (HCCA) patients, and to evaluate the predictive value of the Mayo staging on the prognosis. The Kaplan–Meier survival curve and Log-rank test were used to perform univariate analysis on each index and obtain statistically significant influencing factors. The Kaplan–Meier survival curve and Log-rank test were used to analyze the correlation between the two staging systems and the survival period. The receiver operating characteristic (ROC) curves were used for each single staging system trend analysis, and comparison of their curve area to determine prognosis prediction ability for patients with HCCA. According to Kaplan–Meier survival curve changes and Log-rank test results, it was found that both staging systems were correlated with the survival time of the patients ( P < .001). Through a pairwise comparison within the stages, it was found that the heterogeneity between the stages within the Mayo staging is very good, which was better than the TNM staging. A single trend analysis of the prognostic assessment capabilities of the two systems found that the area under the ROC curve of Mayo staging system (AUC = 0.587) was the largest and better than the TNM staging system (AUC = 0.501). Mayo staging can be used for preoperative patient prognosis assessment which can provide better stratification ability based on a single-center small sample study, and the predictive value is better than TNM staging.

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Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features

Chen

Liu

Huang

et al. 2023

Expert Review of Molecular Diagnostics

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CA19-9 beim intrahepatischen Cholangiokarzinom

Cited by 7 publications

References 14 publications

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Prognostic influence for hilar cholangiocarcinoma and comparisons of prognostic values of Mayo staging and TNM staging systems

Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features

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