Transmissible venereal tumor (TVT), also called Sticker tumor, is classified as a round cell neoplasm that mainly affects the external genitalia of male and female dogs. The most common form of TVT transmission is through coitus, which can also occur through the habit of licking, biting and sniffing. Although less frequent, TVT can still affect cutaneous areas of animals, and when present, they may or may not be associated with the presence of vulvar mass. The diagnosis for TVT is based on the patient's history, physical examination and complementary tests such as histopathology and cytology. Chemotherapy using vincristine sulfate is the treatment of choice, as it is considered effective in most cases. The objective of this study was to report two cases of cutaneous TVT in bitches mixed breed (SRD). One of the described cases also presented nodules in the vulvar region, in addition to cutaneous nodulations. After starting chemotherapy, a satisfactory result was found between the second and third weeks of treatment in both cases. Despite this, the animal in the first report presented anemia and severe leukopenia due to a probable adverse reaction to chemotherapy and died. The second patient presented with discrete areas of alopecia and almost complete reduction of all nodules after the second application. From the information described here, it is possible to conclude the importance of exams prior to applications, to assess the animal's condition and possible adverse effects to chemotherapy.