Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities

Chen, Mi; Pérez, Rocío L.; Du, Pu; Bhattarai, Nimisha; McDonough, Karen C.; Ravula, Sudhir; Kumar, Revati; Mathis, J. Michael; Warner, Isiah M.

doi:10.1021/acsami.9b08047

Cited by 28 publications

(9 citation statements)

References 48 publications

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“…Studies from these researchers have shown that nanoparticle formation is key to the observed selective toxicity [11]. Several reports of anion exchange with tunable antitumor and imaging activities have also been reported [3,[21][22][23][24].…”

Section: Effects Of Anion-exchange In Gumbos and Related Selfassemblymentioning

confidence: 99%

A Review of GUMBOS: Tunable Ionic Materials

Ayala¹

2021

RDMS

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Strategic development of ionic materials has long been of considerable interest to many researchers. For example, ionic liquid research has been extensively explored as alternative solvents to highly volatile and/or caustic traditional organic solvents. While these solvents have been classified as having a range of melting points (below 100 °C), many researchers have targeted relatively low melting point materials for their desired applications. Similar materials with higher melting points were often deemed inefficient and often discarded and declared useless. However, several groups have begun to explore the advantages of solid-phase ionic materials, known as a groups of uniform materials based on organic salts (GUMBOS). Many advantages arise through implementation of these solid-state ILs analogues in different fields of research. These advantages include 1) maintaining ease of synthesis using IL chemistry, 2) exploring easy tunability of solid-state materials, and 3) providing researchers with ability to easily develop materials on the nanoscale. Herein, we provide an overview of advantages of using GUMBOS for materials research applications.

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Section: Effects Of Anion-exchange In Gumbos and Related Selfassemblymentioning

confidence: 99%

A Review of GUMBOS: Tunable Ionic Materials

Ayala¹

2021

RDMS

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“…Finally, major interest has focused on development of new ILs (third generation ILs) for biological applications to achieve biocompatible and low toxic compounds through use of bio-counterions [87,88]. Moving forward, more attention from the scientific community has focused on development, or recycling of, various molecules into solid phase materials (frozen ILs or GUMBOS) for several biological applications [17,[89][90][91]. In this section, the use of frozen ILs and GUMBOS for biological applications such as cancer and antibiotic therapies are discussed.…”

Section: Biological Applicationsmentioning

confidence: 99%

“…For this reason, major interest has been directed toward study of cationic compounds as well as positively charged vesicles as chemotherapeutic agents. Several publications from the literature document that these type of compounds are attracted to, and accumulate more selectively, in this organelle of cancer cells, resulting in disruption of ATP synthesis and subsequent induction of cell death [16,17,22,89,108,109].…”

Section: Gumbos and Nanogumbos As Chemotherapeutic Agentsmentioning

confidence: 99%

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Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

Pérez¹,

Ayala²,

Warner³

2021

Ionic Liquids - Thermophysical Properties and Applications

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Ionic liquids (ILs) are defined as organic salts with melting points below 100 °C. Such ionic compounds are typically formed using bulky cations and/or bulky anions in order to produce liquids or lower melting solids. ILs have been widely explored in several research areas including catalysis, remediation, solvents, separations, and many others. The utility of such compounds has also been recently broadened to include solid phase ionic materials. Thus, researchers have pushed the boundaries of ILs chemistry toward the solid state and have hypothesized that valuable properties of ILs can be preserved and fine-tuned to achieve comparable properties in the solid state. In addition, as with ILs, tunability of these solid-phase materials can be achieved through simple counterion metathesis reactions. These solid-state forms of ILs have been designated as a group of uniform materials based on organic salts (GUMBOS). In contrast to ILs, these materials have an expanded melting point range of 25 to 250 °C. In this chapter, we focus on recent developments and studies from the literature that provide for fine tuning and enhancing properties through transformation and recycling of diverse ionic compounds such as dyes, antibiotics, and others into solid state ionic materials of greater utility.

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“…Cyclodextrins (CDs) have been used to form host-guest inclusion complexes to improve solubility and bioavailability of drugs [10], to which CDs form non-covalent complexes [11,12]. In an aqueous solution, the slightly non-polar cavity is occupied by water molecules that are energetically unfavorable.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model

et al. 2021

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The low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with β-cyclodextrin (β-CD) using three complexation approaches. Molecular docking suggests the hydrogen-bond between POH and β-cyclodextrin in molar proportion was 1:1. Thermal analysis and Fourier-transform infrared spectroscopy (FTIR) confirmed that the POH was enclosed in the β-CD cavity. Also, there was a significant reduction of particle size thereof, indicating a modification of the β-cyclodextrin crystals. The complexes were tested against human L929 fibroblasts after 24 h of incubation showing no signs of cytotoxicity. Concerning the histopathological results, the treatment with POH/β-CD at a dose of 50 mg/kg promoted approximately 60% inhibition of tumor growth in a sarcoma S180-induced mice model and the reduction of nuclear immunoexpression of the Ki67 antigen compared to the control group. Obtained data suggest a significant reduction of cycling cells and tumor proliferation. Our results confirm that complexation of POH/β-CD not only solves the problem related to the volatility of the monoterpene but also increases its efficiency as an antitumor agent.

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Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities

Cited by 28 publications

References 48 publications

A Review of GUMBOS: Tunable Ionic Materials

A Review of GUMBOS: Tunable Ionic Materials

Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model

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