Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature

Garcia, Maria Alice Amorim; Bejarano, P.A.; Yssa, Maria; Buitrago, Efren; Livingstone, Alan S.

doi:10.1007/s00428-006-0251-0

Cited by 56 publications

(49 citation statements)

References 13 publications

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“…The concurrent occurrence of NEC and HCC in the liver is extremely rare with only 8 cases reported[2-9]. They are classified as combined type or collision type based on the presentation of histological distribution.…”

Section: Introductionmentioning

confidence: 99%

Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature

Choi

Ann

Lee

et al. 2016

WJG

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Primary hepatic neuroendocrine carcinoma (NEC) with concurrent occurrence of hepatocellular carcinoma (HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases. A 72-year-old male with chronic hepatitis C was admitted to our hospital for a hepatic mass detected by liver computed tomography (CT) at another clinic. Because the nodule was in hepatic segment 3 and had proper radiologic findings for diagnosis of HCC, including enhancement in the arterial phase and wash-out in the portal and delay phases, the patient was treated with laparoscopic left lateral sectionectomy. The pathology demonstrated that the nodule was 2.5 cm and was moderately differentiated HCC. However, a 3 mm-sized focal neuroendocrine carcinoma was also detected on the capsule of the nodule. The tumor was concluded to be a collision type with HCC and primary hepatic NEC. After the surgery, for follow-up, the patient underwent a liver CT every 3 mo. Five multiple nodules were found in the right hepatic lobe on the follow-up liver CT 6 mo post-operatively. As the features of the nodules in the liver CT and MRI were different from that of HCC, a liver biopsy was performed. Intrahepatic recurrent NEC was proven after the liver biopsy, which showed the same pathologic features with the specimen obtained 6 mo ago. Palliative chemotherapy with a combination of etoposide and cisplatin has been administered for 4 months, showing partial response.

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Section: Introductionmentioning

confidence: 99%

Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature

Choi

Ann

Lee

et al. 2016

WJG

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“…Ex-pulmonary small cell carcinoma is rare, and there are only a few case reports on liver small cell carcinoma [17-23]. In the present study, we have reported the autopsy and biopsy case series of liver predominant/primary small cell carcinoma and identified the unique morphologic and clinical features.…”

Section: Discussionmentioning

confidence: 84%

“…Small cell carcinoma of the lung has been reported to rarely manifest as acute hepatic failure when it metastasizes to liver [16]; however, extra-pulmonary small cell carcinoma is rare, and there are only a few case reports for liver primary/predominant small cell carcinoma [17-23]. Recently, we have identified a few cases of hyper-acute or acute liver failure secondary to diffuse infiltration of the liver primary/predominant small cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Unique morphologic and clinical features of liver predominant/primary small cell carcinoma—autopsy and biopsy case series

et al. 2014

Annals of Diagnostic Pathology

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Liver predominant small cell carcinoma is rare, but often presents as hyper-acute liver failure with unknown primary and is a medical emergency. We present 2 autopsy and 7 biopsy cases of liver predominant small cell carcinoma and demonstrate that these patients present with liver failure and identifiable hepatomegaly, but lack discrete lesions on imaging, as well as no mass lesions identified in other organs including lung. Compared to the multiple nodules of metastatic small cell carcinoma in the liver, unique morphologic feature of liver predominant/primary small cell carcinoma in autopsy and biopsy specimens was a diffuse infiltration of small, blue, neoplastic cells predominantly in the sinusoidal space in the liver parenchyma. Prior to diagnosing liver predominant/primary small cell carcinoma, other infiltrating small blue cell neoplasms including lymphoma and peripheral neuroectodermal tumor need to be ruled out through immunohistochemistry (IHC). We therefore demonstrate that liver biopsy together with a rapid panel of immunostains is necessary to firmly establish a diagnosis of liver predominant small cell carcinoma and allow clinicians to immediately implement potentially lifesaving chemotherapy.

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“…1 There have so far been only 21 cases of primary NET in the liver treated with hepatic resection in the English literature. [6][7][8][9][10][11][12][13] Including our case, the clinical characteristics of these 22 cases of primary NET in the liver that were surgically resected are summarized in Table 1. This type of tumor occurs mainly in middle-aged patients (mean age, 48.7 years) and more frequently in males.…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine tumor in the liver treated by hepatectomy: Report of a case

Mima

Beppu²,

Murata³

et al. 2011

Surg Today

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A 49-year-old woman was admitted to our hospital under suspicion of an enlarging hepatic tumor, which had been previously diagnosed to be a cavernous hemangioma. Computed tomography revealed three enhanced tumors, one measuring 15 cm in diameter within the right lobe of the liver and two intrahepatic metastases in Couinaud's hepatic segments 3 and 5. We diagnosed the patient to have primary liver cancer, and suspected a combined liver tumor preoperatively. We performed a right trisectionectomy with radiofrequency ablation of the intrahepatic metastasis in S3. According to the immunohistochemical findings of the resected specimen and the findings of postoperative imaging studies, the tumor was diagnosed to be a primary neuroendocrine tumor in the liver. The patient is presently alive without recurrence at 33 months after the operation.

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Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature

Cited by 56 publications

References 13 publications

Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature

Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature

Unique morphologic and clinical features of liver predominant/primary small cell carcinoma—autopsy and biopsy case series

Primary neuroendocrine tumor in the liver treated by hepatectomy: Report of a case

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