Unique morphologic and clinical features of liver predominant/primary small cell carcinoma—autopsy and biopsy case series

Lo, Amy A.; Lo, Edward Chin Man; Li, Haonan; Zhang, Wanying; Lü, Jie; Rao, M. Sambasivia; Miller, Frank P.; Yang, Guang

doi:10.1016/j.anndiagpath.2014.02.007

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…All the tumor cells were limited to the sinusoidal space, with no erosion of liver parenchyma. 13,14 Immunostaining for FGF23 was strongly positive for the tumor cells (Figure 1E). Reverse transcriptase polymerase chain reaction (RT-PCR) for FGF23 was also performed by using 3 sets of published primers 19 (Table 2).…”

Section: Pathologymentioning

confidence: 94%

FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma

et al. 2015

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Tumor-induced osteomalacia (TIO) is typically caused by phosphaturic mesenchymal tumor (PMT) that secretes the phosphaturic hormone, fibroblast growth factor-23 (FGF23), resulting in decreased phosphate reabsorption in kidneys, hypophosphatemia, and finally osteomalacia. Rare cases of malignant tumor manifesting with TIO other than PMT had been reported, although in most of these reports, except one, circulating FGF23 levels were not evaluated and tissue expressing of FGF23 was not confirmed. In this article, we report a case of TIO in a patient with pulmonary small cell carcinoma with liver metastasis. The patient manifested with hypophosphatemia. His circulating level of FGF23 was markedly increased. The expression of FGF23 in tumor cells was confirmed. Furthermore, the regulatory mechanism of FGF23 in this patient was also investigated.

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Section: Pathologymentioning

confidence: 94%

FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma

et al. 2015

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“…[4–8] Based on this interval, hyperacute (<7 days) and acute (7–28 days) liver failure is considered. [9] …”

Section: Discussionmentioning

confidence: 99%

Giant hepatic metastasis in a patient with coin-like small cell lung carcinoma incidentally diagnosed at autopsy

Fodor¹,

Gurzu

Contac³

et al. 2017

Medicine

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Rationale:Encephalopathy is a rare complication of hepatic metastases. In this paper we present a case of a patient with lung cancer and metastatic-related giant hepatomegaly.Patient concerns:A 78-year-old previously healthy male was admitted in the Emergency room in hepatic coma.Diagnoses:The abdominal CT scan examination revealed a huge liver filled with solid nodules.Interventions:No interventions were performed.Outcomes:The patient died at few hours after hospitalization. The autopsy showed a 6.5 kilograms liver with several whitish metastatic nodules and an occult prostate adenocarcinoma. The hilum of both lungs was free of tumor and a 10 mm white nodule was identified surrounding a small bronchus. No peripheral nodules were macroscopically identified. Under microscope, cluster of small cells were observed encasing a small bronchus with multiple minute coin-shaped subpleural foci. A massive intrapulmonary angiolymphatic invasion and metastases from small cell carcinoma in liver, lymph nodes and iliac crest bone marrow were also diagnosed.Lessons:This case highlights the difficulty of diagnosis of aggressive lung carcinomas and the necessity of checking for metachronous tumors. The encephalopathy might be the result of metastatic damage of the liver parenchyma combined with the paraneoplastic effect of the tumor cells. Few than 25 cases of SCLCs with diffuse liver metastases and fulminant liver failure were reported to December 2016. This is the first reported case with a synchronous prostate cancer and a “coin-like” aspect of the SCLC.

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“…Seventeen well-described cases of diffuse liver metastases of SCLC causing acute liver failure have been previously reported [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], and these cases differ from cases of liver predominant/primary small-cell carcinoma [ 15 ]. None of these 17 cases had been histologically diagnosed prior to death, despite the absence of any visible nodular lesions in the liver observed using contrast-enhanced CT.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Liver Metastasis of Small-Cell Lung Cancer Presenting as Acute Liver Failure and Diagnosed by Transjugular Liver Biopsy: A Rare Case in Whom Nodular Lesions Were Detected by Enhanced CT Examination

Mishima

Nozaki

Mikami

et al. 2015

Case Rep Gastroenterol

477

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Small-cell lung cancer (SCLC) is a subgroup of lung cancer with a high frequency of liver metastasis, which is a predictor of poor prognosis. Diffuse liver metastases of SCLC with no visible nodular lesions in the liver when examined using computed tomography (CT) are relatively rare; however, a few cases with rapid progression to acute liver failure that were diagnosed after death have been reported. In this paper, we report a 63-year-old man with diffuse liver metastases of SCLC that were histologically diagnosed using a transjugular liver biopsy while the patient was alive, even though no lesions were visible during a contrast-enhanced CT examination.

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Unique morphologic and clinical features of liver predominant/primary small cell carcinoma—autopsy and biopsy case series

Cited by 8 publications

References 19 publications

FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma

FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma

Giant hepatic metastasis in a patient with coin-like small cell lung carcinoma incidentally diagnosed at autopsy

Diffuse Liver Metastasis of Small-Cell Lung Cancer Presenting as Acute Liver Failure and Diagnosed by Transjugular Liver Biopsy: A Rare Case in Whom Nodular Lesions Were Detected by Enhanced CT Examination

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