Tumor necrosis factor-α expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification

Engelhardt, Paul F.; Seklehner, Stephan; Brustmann, Hermann; Riedl, Claus R.; Lusuardi, Lukas

doi:10.3109/21681805.2015.1044560

Cited by 10 publications

(8 citation statements)

References 36 publications

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“…Even though some of the literature has showed that CP/ CPPS is an important health issue in elder population, [25][26][27][28] the present study failed to observe such an association between CP/CPPS and previous colonoscopy in the elderly (≥60 years old). According to anatomical and physiological changes of the prostate in the elderly, a portion of the pathogenesis of prostate inflammation differs from that in young adults.…”

Section: Discussioncontrasting

confidence: 95%

“…We first excluded all subjects who had a history of CP/CPPS since the beginning of the NHI program in 1995. Thereafter, we selected 3933 controls matched with cases by age group (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)30-39, 40-49, 50-59, 60-69, and >69 years) and index year. We selected the controls by matching them to a given CP/CPPS case simply due to use of medical services in the same index year of that particular case.…”

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

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Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Tsai

Lin

Lee

et al. 2017

CUAJ

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Introduction: This study aimed to examine the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and receipt of a prior colonoscopic examination using a populationbased database. Methods: We used the Taiwan Longitudinal Health Insurance Database 2005 to retrieve the study sample. This study included 3933 patients with CP/CPPS and 3933 age-matched controls. We designated the date of receiving the first diagnosis of CP/CPPS as the index date for cases. We defined the first an ambulatory care visit occurring in the matched year as the index date for the controls. Conditional logistic regressions was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for having previously received colonoscopy between cases and controls. Results: We found that 349 (4.44%) of the 7866 sampled patients had previously undergone colonoscopy, including 223 (5.67%) cases and 126 (3.20%) controls (p<0.001). A conditional logistic regression analysis revealed that the adjusted OR of receiving a colonoscopy within three years before the index date was 1.77 (95% CI 1.42-2.23) for cases compared to controls. Furthermore, we found that the youngest group of cases (<40 years) had the greatest adjusted OR for having received colonoscopy within three years before the index date compared to controls (OR 2.81; 95% CI 1.45-5.44); however, in contrast, no significant difference in the adjusted odds of having previously received colonoscopy was observed between cases and controls among the oldest age group (≥60 years). Conclusions: We concluded that there was an association between antecedent colonoscopy and CP/CPPS.

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Section: Discussioncontrasting

confidence: 95%

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Tsai

Lin

Lee

et al. 2017

CUAJ

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“…A great number of scholars tend to verify the important role of the immune factors in the pathogenesis of chronic prostatitis. Engelhardt et al found the increasing expression of IL-2R, IL-6 and TNF-α in prostate tissue of patients with BPH and chronic prostatitis [20,21]. Korrovits et al observed elevation of seminal IL-6 level in patients with chronic prostatitis [17].…”

Section: Resultsmentioning

confidence: 99%

WITHDRAWN: Diagnosis of Chronic Prostatitis by Noninvasive Methods in Elderly Patients with Benign Prostatic Hyperplasia in China

Cao

Guan

et al. 2020

Preprint

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Background: Chronic prostatitis is hard to be identified in benign prostatic hyperplasia (BPH) patients in clinical works. This study aimed to diagnose chronic prostatitis in BPH patients by noninvasive methods.Methods: The research was carried out on the BPH patients who received transurethral resection of prostate at Xinhua hospital from January 2014 to Jul 2015. Before operation, patients were asked for medical history and required to receive physical examination, serum sample collection including PSA, sex hormones, inflammatory cytokines, metabolic panel and transrectal ultrasonography. According to histological results, the patients were divided into 2 group of BPH with/without prostatitis. Logistic regression was used to find the risk factors of chronic prostatitis.Results: As a result, 181 men with an average age of 72.15±8.41 years were enrolled in this study, including 116 patients with prostatitis and 65 patients without prostatitis. The storage sub-score (9.24±1.55 vs 8.52±1.63, p=0.009), PSA (8.23±7.69 vs 4.92±3.84, p=0.005) and IL-2R (531.96±200.75 vs 434.11±153.54, p=0.001) were significantly higher in patients with prostatitis than those without prostatitis. Based on logistic regression analysis, the above three parameters were also the risk factors of BPH with prostatitis. The diagnostic model was calculated as: 0.317* storage sub-score+0.092* PSA+0.003* IL-2R-4.296. The AUC was 0.725. Conclusions: Histological prostatitis in BPH patients can be diagnosed by the combination of serum IL-2R, PSA and storage sub-score. Identification of chronic prostatitis among patients with BPH is beneficial for medical decisions, which can more efficiently alleviate urinary symptoms and reduce the risk of disease progression.

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“… 12 Engelhardt et al showed that a direct association between asymptomatic inflammatory prostatitis NIH category IV, a high incidence of prostatic calcification, and significantly greater TNF-a expression in patients with obstructive BPH. 13 In the present study, we diagnosed inflammation by analyzing inflammatory cells in resected specimens of BPH.…”

Section: Discussionmentioning

confidence: 99%

The effect of prostatic inflammation on clinical outcomes in patients with benign prostate hyperplasia

Cakir

Polat

Özcan³

et al. 2018

Prostate International

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BackgroundTo investigate the effect of asymptomatic inflammatory prostatitis on clinical outcomes of patients undergoing trans urethral resection of prostate due to benign prostatic hyperplasia.Materials and methodsA total of 514 patients were enrolled in the study. Clinical parameters and pathological results were compared before and one year after surgery.ResultsOf the patients 310 were diagnosed with purely benign prostatic hyperplasia and the others were diagnosed with both prostatic inflamation (cathegory IV) and benign prostatic hyperplasia. No statistical significance was observed between two groups among the parameters including age, prostate volume and post voiding residue (P > 0.05). Patients with prostate inflammation presented higher preoperative International Prostate Symptom Score and lower Qmax values when compared to those without inflammation before trans urethral resection of prostate.ConclusionAsymptomatic prostate inflammation can lead to worsen lower urinary tract symptoms and urinary flow rate in patients with benign prostatic hyperplasia. Furthermore, the improvement of the complaints after surgery was worse in patients with asymptomatic prostate inflammation. Further well designed prospective-randomised studies are needed to support our findings.

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Tumor necrosis factor-α expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification

Cited by 10 publications

References 36 publications

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

WITHDRAWN: Diagnosis of Chronic Prostatitis by Noninvasive Methods in Elderly Patients with Benign Prostatic Hyperplasia in China

The effect of prostatic inflammation on clinical outcomes in patients with benign prostate hyperplasia

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