WITHDRAWN: Diagnosis of Chronic Prostatitis by Noninvasive Methods in Elderly Patients with Benign Prostatic Hyperplasia in China

Abstract

Background: Chronic prostatitis is hard to be identified in benign prostatic hyperplasia (BPH) patients in clinical works. This study aimed to diagnose chronic prostatitis in BPH patients by noninvasive methods.Methods: The research was carried out on the BPH patients who received transurethral resection of prostate at Xinhua hospital from January 2014 to Jul 2015. Before operation, patients were asked for medical history and required to receive physical examination, serum sample collection including PSA, sex hormones, inflammatory cytokines, metabolic panel and transrectal ultrasonography. According to histological results, the patients were divided into 2 group of BPH with/without prostatitis. Logistic regression was used to find the risk factors of chronic prostatitis.Results: As a result, 181 men with an average age of 72.15±8.41 years were enrolled in this study, including 116 patients with prostatitis and 65 patients without prostatitis. The storage sub-score (9.24±1.55 vs 8.52±1.63, p=0.009), PSA (8.23±7.69 vs 4.92±3.84, p=0.005) and IL-2R (531.96±200.75 vs 434.11±153.54, p=0.001) were significantly higher in patients with prostatitis than those without prostatitis. Based on logistic regression analysis, the above three parameters were also the risk factors of BPH with prostatitis. The diagnostic model was calculated as: 0.317* storage sub-score+0.092* PSA+0.003* IL-2R-4.296. The AUC was 0.725. Conclusions: Histological prostatitis in BPH patients can be diagnosed by the combination of serum IL-2R, PSA and storage sub-score. Identification of chronic prostatitis among patients with BPH is beneficial for medical decisions, which can more efficiently alleviate urinary symptoms and reduce the risk of disease progression.