Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery

Eisermann, Juergen; Gast, Michael J.; Pineda, Jorge A.; Odem, Randall R.; Collins, John Leslie

doi:10.1016/s0015-0282(16)60185-1

Cited by 267 publications

(124 citation statements)

References 21 publications

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“…Cytokines such as interleukin-I and tumor necrosis factor-c~ appear to inhibit embryonic development (20). Higher quantities of these factors have been found in the peritoneal fluid of women with endometriosis (21)(22)(23)(24), and treatment of endometriosis decreases the level of cytokines, which results in decreased embryo toxicity (20). Other proposed mechanisms through which endometriosis can impair fertility include autoantibodies adversely affecting embryo implantation (16) and endometrial receptor defects such as a deficiency of the integrin, e~v[33 (7).…”

Section: Discussionmentioning

confidence: 99%

Endometriosis is not detrimental to embryo implantation in oocyte recipients

Sung

Mukherjee

Takeshige

et al. 1997

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 99%

Endometriosis is not detrimental to embryo implantation in oocyte recipients

Sung

Mukherjee

Takeshige

et al. 1997

J Assist Reprod Genet

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“…Dienogest clearly demonstrated a striking protective effect against buserelininduced bone mineral loss without reducing the potency of the effect on endometrial implants, indicating that dienogest is a promising agent in combination with buserelin for the treatment of endometriosis. Recently, some investigators have reported an increase in the number of activated macrophages (26) and an increase in the levels of IL-1b and tumor necrosis factor-a (27) in the peritoneal fluid of patients with endometriosis, as well as a decrease in these cytokine levels after medical treatment (27,28). Peritoneal macrophages and macrophage-induced IL-1 may contribute to infertility caused by endometriosis (29).…”

Section: European Journal Of Endocrinology (1998) 138mentioning

confidence: 99%

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Katsuki

Takano

Futamura

et al. 1998

European Journal of Endocrinology

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Objective: Dienogest, a synthetic steroid with progestational activity, is used as a component of oral contraceptives and is currently being evaluated clinically for the treatment of endometriosis. The present study was conducted to confirm the effects of dienogest on experimental endometriosis in rats and to elucidate its mechanism of action. Design: Experimental endometriosis induced by autotransplantation of endometrium in rats. Methods: Endometrial implants, immune system, and bone mineral were investigated after 3 weeks of medication. Results: Dienogest (0.1-1 mg/kg per day, p.o.) reduced the endometrial implant volume to the same extent as danazol (100 mg/kg per day, p.o.). Simultaneously, dienogest ameliorated the endometrial implant-induced alterations of the immune system; i.e. it increased the natural killer activity of peritoneal fluid cells and splenic cells, decreased the number of peritoneal fluid cells, and decreased interleukin-1b production by peritoneal macrophages. In contrast, danazol (100 mg/kg per day, p.o.) and buserelin (30 mg/kg per day, s.c.) had none of these immunologic effects. Additionally, combined administration of dienogest (0.1 mg/kg per day) plus buserelin (0.3 mg/kg per day) suppressed the bone mineral loss induced by buserelin alone, with no reduction of the effect on endometrial implants. In vitro studies on dienogest revealed an antiproliferative effect on rat endometrial cells due to inhibition of protein kinase C activity plus a partial progestational effect.Conclusions: Dienogest appears to be a potent agent with mechanisms of action different from those of danazol and GnRH agonists currently available for the treatment of endometriosis. European Journal of Endocrinology 138 216-226

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“…105 This strongly suggests that other aspects of pain are present and that surgical excision and suppression of oestrogen is not sufficient in the management of such pain. 106 Possibly, herbal drugs may prove to be efficacious complements. 28;107 Endometriosis also results in sensitisation of nociceptors with one of the main contributing factors being the prostanoid PGE2.…”

Section: Pain and Hormones In Endometriosismentioning

confidence: 99%

Is There a Role for Acupuncture in Endometriosis Pain, Or ‘endometrialgia’?

Lundeberg

Lund

2008

Acupunct Med

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Endometriosis is a common cause of pelvic pain in women, many of whom suffer a progression of symptoms over their menstrual life. Symptoms may include combinations of abnormal visceral sensations and emotional distress. Endometriosis pain, or ‘endometrialgia’ often has a negative influence on the ability to work, on family relationships and sense of worth. Endometrialgia is often considered to be a homogeneous sensory entity, mediated by a specialised high threshold sensory system, which extends from the periphery through the spinal cord, brain stem and thalamus to the cerebral cortex. However, multiple mechanisms have been detected in the nervous system responsible for the pain including peripheral sensitisation, phenotypic switches, central sensitisation, ectopic excitability, structural reorganisation, decreased inhibition and increased facilitation, all of which may contribute to the pain. Although the causes of endometrialgia can differ (eg inflammatory, neuropathic and functional), they share some characteristics. Endometrialgia may be evoked by a low intensity, normally innocuous stimulus (allodynia), or it may be an exaggerated and prolonged response to a noxious stimulus (hyperalgesia). The pain may also be spontaneous in the absence of any apparent peripheral stimulus. Oestrogens and prostaglandins probably play key modulatory roles in endometriosis and endometrialgia. Consequently many of the current medical treatments for the condition include oral drugs, like non-steroid anti-inflammatory drugs, contraceptives, progestogens, androgenic agents, gonadotrophin releasing hormone analogues, as well as laparoscopic surgical excision of the endometriosis lesions. However, management of pain in women with endometriosis is currently inadequate for many. Possibly acupuncture and cognitive therapy may be used as an adjunct.

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Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery

Cited by 267 publications

References 21 publications

Endometriosis is not detrimental to embryo implantation in oocyte recipients

Endometriosis is not detrimental to embryo implantation in oocyte recipients

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Is There a Role for Acupuncture in Endometriosis Pain, Or ‘endometrialgia’?

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