Objective To evaluate the relation of endometrial thickness (EnT) and endometrial pattern (EnP) to euploid embryo transfer (ET) outcomes. Design Retrospective cohort Setting Private academic clinic Patients Patients (n=277, 36.1±4.0 years) whose embryos (n=476) underwent aneuploidy screening with fresh (n=176) or frozen (n=180) ET from July 2010–March 2014. Interventions EnT and EnP were measured on trigger day and at ET. Patients were stratified by age and cycle type (fresh or frozen). Cycle data were combined at trigger day but separated at ET day. Main Outcome Measures Outcome measures were implantation (IR), pregnancy (PR) and clinical pregnancy (CPR) rates. Analysis was conducted by chi-square and Fisher exact test with significance at p<0.05. Results 234 gestational sacs, 251 pregnancies and 202 clinical pregnancies resulted from 356 cycles. EnT (9.6±1.8mm; range 5–15mm) at trigger day (n=241 cycles) as a continuous or categorical (≤8 vs >8mm) variable was not associated with IR, PR or CPR. EnT at day of fresh (9.7±2.2mm; range 4.4–17.9mm) (n=176 cycles) or frozen ET (9.1±2.1mm; range 4.2–17.7mm) (n=180 cycles) was not associated with IR, PR or CPR. Type 3 EnP at trigger day was associated with increased serum progesterone at trigger and decreased IR compared with type 2 EnP. EnP at fresh or frozen ET was not associated with IR, PR or CPR. Conclusions Within the study population, EnT was not significantly associated with clinical outcomes of euploid ETs. A type 3 EnP at trigger day suggests a prematurely closed window of implantation.

No abstract

No abstract