Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

Güven, Orhan; Tekin, Umut; Salmanoğlu, Berrin; Kaymak, Emre

doi:10.1016/j.jcms.2014.10.017

Cited by 22 publications

(20 citation statements)

References 34 publications

(44 reference statements)

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“…The clinical symptoms of TMJ disorders include pain and dysfunction of movement, which are essentially signs of an inflammatory condition in the TMJ . Normally, the synovial membrane is impermeable to high molecular weight plasma globulins.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical symptoms of TMJ disorders include pain and dysfunction of movement, which are essentially signs of an inflammatory condition in the TMJ. 25 Normally, the synovial membrane is impermeable to high molecular weight plasma globulins. However, with the development of synovial inflammation, the membrane becomes permeable to plasma proteins, and the protein level in SF increases as a result.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Kaya

Yavuz

Kızıltunç

2018

J of Oral Rehabilitation

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The synovial membrane and fluid are significantly involved in the pathogenesis of temporomandibular joint (TMJ) disorders. This study aimed to investigate the relation between levels of chemerin in the synovial fluid (SF) of patients with TMJ disorder and their relationship. Sixty samples of SF were obtained from patients with an internal derangement (ID) or osteoarthritis (OA). Chemerin in the SF was examined by enzyme-linked immunosorbent assay (ELISA). The results showed greater levels of chemerin in the SF of patients with OA than ID. While chemerin levels were positively correlated with pain scores, they were inversely correlated with MMO. Chemerin levels increased progressively as the disorder stage became more severe. The findings of this study suggest that chemerin in SF may play role as a predisposing factor and may represent a novel potential prognostic biochemical marker in the pathogenesis of TMJ disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Kaya

Yavuz

Kızıltunç

2018

J of Oral Rehabilitation

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“…In the case of IL-8, this chemokine participates to the inflammatory process in the early synovitis of rheumatoid arthritis (58), and similar to IL-1β, the intra-articular administration has been also used to induce acute synovitis in rabbits (59). Finally, the level of TNF-α in synovia has been correlated with pain and disease progression (60, 61) and anti-TNF-α agents have been widely used for the treatment of active rheumatoid arthritis (62, 63). …”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model

et al. 2017

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Synovitis is an inflammatory process associated with pain, disability, and discomfort, which is usually treated with anti-inflammatory drugs or biological agents. Mesenchymal stem cells (MSCs) have been also successfully used in the treatment of inflammatory-related diseases such as synovitis or arthritis. In the last years, the exosomes derived from MSCs have become a promising tool for the treatment of inflammatory-related diseases and their therapeutic effect is thought to be mediated (at least in part) by their immunomodulatory potential. In this work, we aimed to evaluate the anti-inflammatory effect of these exosomes in an antigen-induced synovitis animal model. To our knowledge, this is the first report where exosomes derived from MSCs have been evaluated in an animal model of synovitis. Our results demonstrated a decrease of synovial lymphocytes together with a downregulation of TNF-α transcripts in those exosome-treated joints. These results support the immunomodulatory effect of these exosomes and point out that they may represent a promising therapeutic option for the treatment of synovitis.

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“…Thus, AA (24) concluded that TNF-α may contribute to the pathogenesis of TMJ cartilage and bone degeneration. In addition, TNF-α induces the production of other pro-inflammatory cytokines such as IL-1, IL-6, and IL-8 (25), which in turn determines the down-regulation of lubricin (17).…”

Section: Discussionmentioning

confidence: 99%

Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements

Leonardi¹,

Perrotta²,

Almeida³

et al. 2016

Med Oral

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BackgroundTo understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).Material and MethodsA total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.ResultsThe mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.ConclusionsThe results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed. Key words:Lubricin, TMJ, derangements, synovial fluid.

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Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

Cited by 22 publications

References 34 publications

Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model

Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements

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