Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements

Abstract

BackgroundTo understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).Material and MethodsA total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.ResultsThe mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.ConclusionsThe results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed. Key words:Lubricin, TMJ, derangements, synovial fluid.

Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey

“…The presence of estrogen receptors in the temporomandibular joint of female baboons [ 16 , 71 ] could be the basis of an explanation for the higher prevalence of the dysfunction in young women reported in the literature [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ], and the high feedback we have noted of joint noises in pregnant women.…”

“…In general, women are more affected than men by craniomandibular dysfunctions with a ratio of 4 to 1 [ 10 , 11 , 12 , 13 , 14 ]. The prevalence of clicks, headaches, teeth tightening, hypomobility, difficulty in chewing, and neuromuscular symptoms has been shown to be significantly higher among young women (<30 years) [ 15 , 16 , 17 , 18 , 19 , 20 ]. Moreover, there was a significant correlation between the severity of symptoms and age among women, and a relative reduction in clinical symptoms with age in both sexes [ 10 , 11 , 12 , 13 , 15 , 16 , 21 , 22 ].…”

“…The prevalence of clicks, headaches, teeth tightening, hypomobility, difficulty in chewing, and neuromuscular symptoms has been shown to be significantly higher among young women (<30 years) [ 15 , 16 , 17 , 18 , 19 , 20 ]. Moreover, there was a significant correlation between the severity of symptoms and age among women, and a relative reduction in clinical symptoms with age in both sexes [ 10 , 11 , 12 , 13 , 15 , 16 , 21 , 22 ]. Previous evidence reported that estrogen receptors are localized in the TMJ tissues, such as chondroid tissue of condyle and retrodiscal tissues [ 6 , 17 , 18 , 23 , 24 , 25 , 26 , 27 ].…”

Interface between Periodontal Tissues and Dental Materials: Dynamic Changes and Challenges

“…In this regard, much attention should be paid to the periodontium's response to irritants resulting from imprudent techniques, which can initiate or add to existing gingival inflammation. In turn, loss of periodontal support and subsequent tooth loss can occur if the condition is not recognized and treated in its early stages [4][5][6][7][8]. Dental restorations or appliances are often associated with the development of gum inflammation, especially when they are subgingivally located.…”

Temporomandibular joint damage in K/BxN arthritic mice

“…They are essential for maintaining homeostatic functions under noninflammatory conditions, such as the synthesis of the synovial fluid components proteoglycans and lubricin. 22 In contrast, FLSs are active contributors to synovial inflammation and cartilage damage in the context of rheumatoid arthritis. 23 Our observations of TMJ cartilage alterations in K/BxN mice prompted us to analyze the functional properties of TMJ FLSs in more detail.…”