Tumor microenvironment responsive drug delivery systems

He, Qunye; Chen, Jun; Yan, Jun; Cai, Shundong; Xiong, Hongjie; Liu, Yanfei; Peng, Dongming; Mo, Miao; Liu, Zhenbao

doi:10.1016/j.ajps.2019.08.003

Cited by 142 publications

(97 citation statements)

References 210 publications

(310 reference statements)

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“…Zhang et al made inflammation-targeting hydrogel microfibers that were loaded with anti-inflammatory agents [141]. The microfibers showed preferential adhesion to the inflamed epithelial surface, and the drug was released with the rupture of hydrogel capsule in inflamed tissue, under the catalysis of the overexpressed esterase [142].…”

Section: Enzyme-triggered Drug Releasementioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

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Section: Enzyme-triggered Drug Releasementioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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“…At the same time, they also sense changes in the biophysical properties of the TME and adapt their behavior (see below). The increased interstitial pressure of the TME impedes the access of anti-cancer drugs to the tumor mass [ 1 , 2 , 53 ].…”

Section: Fibrillar and Non-fibrillar Ecm Components Orchestrate Thmentioning

confidence: 99%

“…It is shaped in an orchestrated manner by the oncogenically transformed cells and their neighboring tissue cells. It comprises cellular and noncellular constituents of macromolecular size and smaller molecules, as well as several biophysical parameters, such as pH, redox status [ 1 ], and mechanical tension within the tissue [ 2 , 3 ] ( Figure 1 ). Among the small molecules, aberrant concentrations of redox potential-determining compounds, such as glutathione and reactive oxygen species (ROS) as well as extracellular ATP, characterize the TME [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Niland

Eble

2020

IJMS

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The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs.

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“…Firstly, using only the EPR effect or only one array to targeted delivery of nanocarriers is not so efficient that can be relied on as a potential targeting delivery technique. It is proposed for researchers that the good candidates for overcoming this kind of problems are the nanocarriers exploiting both passive and active delivery with multiple arrays and more complex surface modification, like that for pH‐responsive ligands, which are exposed when meeting lower pH (around 5.5) and hidden in neutral pH 99 …”

Section: Future Perspectivementioning

confidence: 99%

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

Abasian

Shakibi

Maniati

et al. 2020

Polymers for Advanced Techs

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Science has been trying to deal with complex diseases, like cancer, for a long time. Indeed, the side effects of the conventional treatment methods are tremendous, in some cases irreversible. This kind of problems demands a solution. Therefore, novel drug delivery systems are devised to mitigate the negative impacts of conventional ones. Polymeric nanocarrier systems are of great importance in this newly opened field. Polymers having been vastly investigated are common in some properties, such as their being biocompatibility and biodegradability. Generally speaking, a set of properties is required to achieve optimum delivery of drugs to target organs with minimum side effects. To do so, some measures should be taken. First of all, the strategy for release should be determined, categorized into two main branches, active and passive. Next, the drug release method should be engineered. Generally, there are two main categories for drug release, exogenous and endogenous. In this review, some of the chief subcategories of any aforementioned items are discussed. In the end, we catch up on already engineered nanocarriers' administration to the human body, possible toxic effects, if any, and the routes for affecting as a toxin.

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Tumor microenvironment responsive drug delivery systems

Cited by 142 publications

References 210 publications

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

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