Tumor microenvironment and NIR laser dual-responsive release of berberine 9-<i>O</i>-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy

Du, Peifang; Yan, Jun; Long, Shuo; Xiong, Hongjie; Wen, Nachuan; Cai, Shundong; Wang, Yirong; Peng, Dongming; Liu, Zhenbao; Liu, Yanfei

doi:10.1039/d0tb00489h

Cited by 38 publications

(23 citation statements)

References 45 publications

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“…Additionally, the detection performance and safety of MOF-based biosensing need to be further verified in vivo due to the complex in vivo environment, and the long-term biological toxicity of metal ion in MOF need to be further evaluated in vivo ( Chen et al, 2019 ), some biocompatible metal ions, such as Fe 2+ /Fe 3+ , Ni 3+ , Zr 4+ , Mn 2+ , Mg 2+ , Ca 2+ , Zn 2+ , or biomaterials, such as liposomal ( Dunne et al, 2019 ), bioconjugates ( Malfanti et al, 2019 ), and green synthetic routes should also be considered. The functional modification of MOFs with target ligands, such as aptamers ( Cai et al, 2018 ; He et al 2020a , 2020b ; Liu et al 2014a , 2015 ; Xiong et al, 2019 ) would endow the MOFs with more functionalities, with detection performances even better than the biosensor platforms based on graphene oxide ( Du et al, 2020 ; Liu et al, 2014b ).…”

Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“… 112 , 113 The specific hybridization of probe DNA (P-DNA) with target virus-related nucleic acids sequences could form stable rigid double or triple-stranded DNA structures and would be released from the surface of MOF due to their low affinity toward nanomaterials, leading to efficient recovery of fluorescence. 26 , 41 , 112 , 113 The possible nucleic acid detection mechanism and quenching/recovery processes are depicted in Fig. 10 .…”

Section: Prospective View Of Mofs As Biosensing Materials For Covid-19mentioning

confidence: 99%

“… 27 , 75 MOFs functional modification with target ligands ( viz : aptamers) 12 , 38 enhance its functionalities, with detection performances much better than the biosensor platforms based on graphene oxide. 26 …”

Section: Prospective View Of Mofs As Biosensing Materials For Covid-19mentioning

confidence: 99%

Metal Organic Frameworks as Biosensing Materials for COVID-19

2021

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The novel coronavirus disease (COVID-19) pandemic outbreak is the most startling public health crises with attendant global socio-economic burden ever experienced in the twenty-first century. The level of devastation by this outbreak is such that highly impacted countries will take years to recover. Studies have shown that timely detection based on accelerated sample testing and accurate diagnosis are crucial steps to reducing or preventing the spread of any pandemic outbreak. In this opinionated review, the impacts of metal organic frameworks (MOFs) as a biosensor in a pandemic outbreak is investigated with reference to COVID-19. Biosensing technologies have been proven to be very effective in clinical analyses, especially in assessment of severe infectious diseases. Polymerase chain reactions (PCR, RT-PCR, CRISPR) - based test methods predominantly used for SARS-COV-2 diagnoses have serious limitations and the health scientists and researchers are urged to come up with a more robust and versatile system for solving diagnostic problem associated with the current and future pandemic outbreaks. MOFs, an emerging crystalline material with unique characteristics will serve as promising biosensing materials in a pandemic outbreak such as the one we are in. We hereby highlight the characteristics of MOFs and their sensing applications, potentials as biosensors in a pandemic outbreak and draw the attention of researchers to a new vista of research that needs immediate action.

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“…Additionally, the assessment of berberine derivatives with cis-substituents at positions C9 and C13 [117,118] or 13-[CH2CO-Cys-(Bzl)-OBzl]-berberine [119] and a series of berberine derivatives with modified position 9-O [120,121] was described. The methylene-dioxy and methoxyl groups in berberine seem to be especially important for the anticancer activity exhibited by its derivatives [122].…”

Section: Challenge To New Derivatives and Formulations Of Berberinementioning

confidence: 99%

Biological Activity of Berberine—A Summary Update

Och

Podgórski

Nowak

2020

Toxins

103

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Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical pathways, especially its proapoptotic and anti-inflammatory activity. Therefore, the growing number of papers on berberine demands summarizing the knowledge and research trends. The efficacy of berberine in breast and colon cancers seems to be the most promising aspect. Many papers focus on novel therapeutic strategies based on new formulations or search for new active derivatives. The activity of berberine is very important as regards sensitization and support of anticancer therapy in combination with well-known but in some cases inefficient therapeutics. Currently, the compound is being assessed in many important clinical trials and is one of the most promising and intensively examined natural agents.

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Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy

Abstract: Stimuli-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in AS1411-functionalized graphene oxide nanosheets for chemo-photothermal synergetic therapy of cancer.

Cited by 38 publications

References 45 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Metal Organic Frameworks as Biosensing Materials for COVID-19

Biological Activity of Berberine—A Summary Update

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