Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland

Umeda, Masahiro; Nishimatsu, Naruki; Masago, Hiroshi; Ishida, Yoshiki; Yokoo, Satoshi; Fujioka, Manabu; Shibuya, Yasuyuki; Komori, Takahide

doi:10.1016/s1079-2104(99)70065-x

Cited by 39 publications

(30 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The estimated doubling time of pulmonal metastasis in ACC ranges from 86 to 1064 days with an average of 393 days. These findings suggest that metastasis at the cellular level could occur prior (average, 227 months) to clinical presentation of primary cancer (Umeda et al 1999). Due to the high incidence of occult pulmonary metastases they should be included in the therapy of the primary cancer.…”

Section: Discussionmentioning

confidence: 95%

Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Teymoortash

Pientka

Schrader³

et al. 2005

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 95%

Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Teymoortash

Pientka

Schrader³

et al. 2005

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…11 The number of patients with metastases elsewhere in the body might, however, be higher than reported, because these can be``silent'' metastases that have not been detected at the time of death. In only a few patients, an autopsy was performed.…”

Section: Discussionmentioning

confidence: 99%

Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow‐up

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Without recurrence, the 5-year os in our cohort was 77%; with recurrence, it was 43%, indicating that, although recurrence is associated with mortality, the disease is not rapidly fatal. The reported tumour doubling time in acc ranges from 86 days to 1064 days, with an average of 393 days, explaining why subclinical metastatic deposits can manifest as disease 10-15 years after initial treatment 31 . In addition, 10% of the recurrences presented after 5 years of follow-up, suggesting the importance of long-term clinical follow-up given the indolent nature of acc and its potential for late recurrences.…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Siever

Hao

et al. 2016

Current Oncology

View full text Add to dashboard Cite

Objectives Adenoid cystic carcinoma (acc) is often treated with surgery, with or without adjuvant radiation therapy (rt). We evaluated disease characteristics, treatments, and potentially prognostic variables in patients with acc.Methods Our retrospective analysis considered consecutive cases of acc presenting at a tertiary care hospital between 2000 and 2014. Factors predictive of overall survival (os) and disease-free survival (dfs) were identified by univariate analysis. ResultsThe 60 patients analyzed had a mean age of 58 years (range: 22-88 years), with a 2:1 female:male ratio. Tumour locations included the major salivary glands (40% parotid, 17% submandibular and sublingual), the oro-nasopharyngeal cavity (27%), and other locations (16%). Of the 60 patients, 35 (58%) received surgery with adjuvant rt; 12 (20%), rt only; 13 (22%), surgery only. Of 18 patients (30%) who experienced a recurrence within 5 years, 3 (5%) developed local recurrence only, and the remaining 15 (25%), distant metastasis. The 5-year os and dfs were 64.5% [95% confidence interval (ci): 45.9% to 78.1%] and 46.2% (95% ci: 29.7% to 61.2%) respectively. In patients without recurrence, 5-year os was 77% (95% ci: 52.8% to 89.9%), and in patients with recurrence, it was 42.7% (95% ci: 15.8% to 67.6%). Patients treated with rt only had a 5-year os of 9.2%. Predictors of 5-year dfs were TNM stage, T stage, nodal status, treatment received, and margin status; age, nodal status, treatment received, and margin status predicted 5-year os.Conclusions Despite surgery and rt, one third of patients with acc experience distant recurrence. Patients whose tumours are not amenable to surgery have a poor prognosis, indicating a need for alternative approaches to improve outcomes.

show abstract

Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland

Cited by 39 publications

References 10 publications

Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow‐up

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Contact Info

Product

Resources

About