Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Teymoortash, Afshin; Pientka, Anna; Schrader, Carsten; Tiemann, Markus; Werner, Jochen A.

doi:10.1007/s00432-005-0040-1

Cited by 27 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elevated Gal-3 levels have been associated with a wide range of neoplasms and events that may promote tumor progression and metastasis [15,16,17]. The potential diagnostic usage of Gal-3 has been supported by studies in thyroid, pulmonary, gastric, colon cancer and anoplastic large-cell lymphoma, although inconsistent results have been suggested from different studies [18,19]. According to recent studies, Gal-3 play an important role in malignant potentials of the CNS tumors, pituitary cell proliferation and tumor progression; and ACTH pituitary carcinoma expresses a higher level of Gal-3 in comparison to pituitary adenoma [17,20].…”

Section: Discussionmentioning

confidence: 96%

GAL3 Protein Expression is Related to Clinical Features of Prolactin-Secreting Pituitary Microadenoma and Predicts its Recurrence after Surgical Treatment

Dai

Li²,

Lu³

et al. 2014

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: Previous in vitro study showed that Galectin-3 (Gal-3) protein plays an important role in pituitary tumorigenesis, however, the association of Gal-3 expression with the clinical feature and prognosis of pituitary tumor in a clinical setting remains unknown. Methods: We enrolled 220 patients with prolactin-secreting pituitary adenomas (PA) who previously had transsphenoidal pituitary surgery. The Gal-3 expression was detected in the patients' PA samples using immunohistochemistry and those patients were followed up. A prolactin-secreting PA cell line, the MMQ cell line, was used to study the in vitro effect of Gal-3 on proliferation, migration and invasion of PA cells using small interfering RNA (siRNA) transfecton technique. The in vivo tumorgenesis in nude mice was also studied. Results: We found that Gal-3 expression was not related to age and sex, but positively associated with tumor invasion (P<0.001), tumor sizes (P<0.001) and pre-operative prolactin levels (P<0.001). The multivariate Cox analysis showed that the Gal-3 expression was closely associated with the recurrence of PA after the surgical treatment (HR =3.15, P=0.002). The in vitro studies showed that Gal-3 knock-down by the siRNA technique significantly inhibited the proliferation, migration and invasion ability of the MMQ cells, whereas Gal-3 siRNA transfection induced apoptosis of the MMQ cells. The in vivo tumorgenesis assay showed that Gal-3 siRNA transfection significantly inhibited the tumor volume in vivo compared to transfection of the control siRNA (P<0.001). Conclusion: Gal-3 regulates proliferation, apoptosis, migration and invasion of the MMQ cells. Gal-3 may be used as a tissue marker to evaluate the clinical feature and prognosis of PA patients.

show abstract

Section: Discussionmentioning

confidence: 96%

GAL3 Protein Expression is Related to Clinical Features of Prolactin-Secreting Pituitary Microadenoma and Predicts its Recurrence after Surgical Treatment

Dai

Li²,

Lu³

et al. 2014

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Recently, genes such as LGALS3, 33 HnRPA1, 34 and EPHA1 35 have received attention as emerging potential targets for oncogenesis and cancer therapy. FLJ21588 (ASCC2), TRIM4, MAPRE3, MIG12, 36 and OIP5 have been newly identified as promising oncogenes in this study, even though further studies of these genes will be needed to ensure their involvements in tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Rapid Screen of Human Genes for Relevance to Cancer Using Fission Yeast

Chung¹,

Jang²,

Kim³

et al. 2007

SLAS Discovery

View full text Add to dashboard Cite

“…In a study of 35 adenoid cystic carcinomas, the expression of galectin -3 , a betagalactoside-binding lectin implicated in tumour progression and metastasis, was investigated. A signifi cant correlation with regional and distant metastasis was found but no statistical significance in the correlation of galectin-3 expression and disease-free survival and overall survival rate [ 184 ]. Detection of apoptosis by the TUNEL method showed that patients with tumours having a high apoptotic index had a better cumulative survival than patients with a low apoptotic index [ 89 ].…”

Section: Predictive Factors Treatment and Prognosismentioning

confidence: 97%

Adenoid Cystic Carcinoma

Hellquist

Skálová

2014

Histopathology of the Salivary Glands

View full text Add to dashboard Cite

Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis

Abstract: Galectin-3 may be used as an indicator in the prediction of metastatic spread in ACC.

Cited by 27 publications

References 30 publications

GAL3 Protein Expression is Related to Clinical Features of Prolactin-Secreting Pituitary Microadenoma and Predicts its Recurrence after Surgical Treatment

GAL3 Protein Expression is Related to Clinical Features of Prolactin-Secreting Pituitary Microadenoma and Predicts its Recurrence after Surgical Treatment

Rapid Screen of Human Genes for Relevance to Cancer Using Fission Yeast

Adenoid Cystic Carcinoma

Contact Info

Product

Resources

About