Adenoid Cystic Carcinoma

Hellquist, Henrik B.; Skálová, Alena

doi:10.1007/978-3-540-46915-5_8

Cited by 8 publications

(8 citation statements)

References 185 publications

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“…The incidence of ACC is more frequent in minor salivary glands as compared with major salivary glands and the reported sites include the nose, paranasal sinuses, palate, trachea, tongue, lacrimal glands, larynx, breast, prostate, uterus, vulva, skin and the external auditory canal 1 2. Histopathologically, ACCs show three growth patterns, namely cribriform, tubular and solid form, and they are graded according to Batsakis et al into three grades.…”

Section: Descriptionmentioning

confidence: 99%

Perivascular spread of adenoid cystic carcinoma: a novel imaging sign

Kumar

Hasan²,

Paulraj

et al. 2015

BMJ Case Reports

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Section: Descriptionmentioning

confidence: 99%

Perivascular spread of adenoid cystic carcinoma: a novel imaging sign

Kumar

Hasan²,

Paulraj

et al. 2015

BMJ Case Reports

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“…Familial history, toxic exposures, or environmental exposures are not associated with increased risk of ACC . In the parotid gland, ACC is the second most common cancer type, occurring in 7% to 18% of cases; however, ACC is most common cancer type in the sublingual, submandibular, and minor salivary glands ACC also occurs in other airway sites, including the paranasal sinuses, lips, larynx, trachea, and nasolacrimal tract .…”

Section: Introductionmentioning

confidence: 99%

“…In the parotid gland, ACC is the second most common cancer type, occurring in 7% to 18% of cases; however, ACC is most common cancer type in the sublingual, submandibular, and minor salivary glands ACC also occurs in other airway sites, including the paranasal sinuses, lips, larynx, trachea, and nasolacrimal tract . Outside of the aerodigestive tract, ACC arises in diverse sites that contain glandular structures, such as the breast, prostate, skin, and female genital tract .…”

Section: Introductionmentioning

confidence: 99%

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Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target

Yarbrough

Panaccione

Chang

et al. 2016

Laryngoscope Investig Oto

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ObjectivesThis review surveys trialed therapies and molecular defects in adenoid cystic carcinoma (ACC), with an emphasis on neural crest‐like stemness characteristics of newly discovered cancer stem cells (CSCs) and therapies that may target these CSCs.Data SourcesArticles available on Pubmed or OVID MEDLINE databases and unpublished data.Review MethodsSystematic review of articles pertaining to ACC and neural crest‐like stem cells.ResultsAdenoid cystic carcinoma of the salivary gland is a slowly growing but relentless cancer that is prone to nerve invasion and metastases. A lack of understanding of molecular etiology and absence of targetable drivers has limited therapy for patients with ACC to surgery and radiation. Currently, no curative treatments are available for patients with metastatic disease, which highlights the need for effective new therapies. Research in this area has been inhibited by the lack of validated cell lines and a paucity of clinically useful markers. The ACC research environment has recently improved, thanks to the introduction of novel tools, technologies, approaches, and models. Improved understanding of ACC suggests that neural crest‐like stemness is a major target in this rare tumor. New cell culture techniques and patient‐derived xenografts provide tools for preclinical testing.ConclusionPreclinical research has not identified effective targets in ACC, as confirmed by the large number of failed clinical trials. New molecular data suggest that drivers of neural crest‐like stemness may be required for maintenance of ACC; as such, CSCs are a target for therapy of ACC.

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“…It arises in all age groups, with a peak incidence in the fifth and sixth decades, and women are slightly more affected 1–3 5. AdCC originates from ductal (luminal) and basal/myoepithelial (abluminal) cells arranged in a glandular (cribriform), tubular or solid growth pattern 6. Diagnosis can be enhanced by detecting fusion of the cellular Myeloblastosis Gene (MYB) to the transcription factor gene NFIB , which is present in the majority of AdCC cases 1…”

Section: Introductionmentioning

confidence: 99%

High CXCR4 expression in adenoid cystic carcinoma of the head and neck is associated with increased risk of locoregional recurrence

et al. 2020

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AimTreatment options for head and neck adenoid cystic carcinoma (AdCC) are limited in advanced disease. Chemokine receptor type 4 (CXCR4) is present in various tumour types, including AdCC. Upregulation is associated with tumour recurrence and metastasis. New CXCR4-specific diagnostic and therapeutic target agents have recently been available. This study aimed to analyse CXCR4 expression in a cohort of primary head and neck AdCC.MethodsAfter histopathological revision, tumour tissues of 73 consecutive patients with AdCC over 1990–2016 were sampled on a tissue microarray. Slides were immunohistochemically stained for CXCR4 and semiquantitatively scored. Associations between protein expression and cliniopathological parameters were tested. HRs were calculated using a Cox proportional hazard model.ResultsSixty-six tumours could be analysed. CXCR4 expression was present in 81% of the tumours with a median of 29% (IQR 1–70) positive cells. Expression was univariately correlated to perineural growth (Spearman ρ .26, p=0.04) and bone invasion (Spearman ρ .32, p=0.01), but not with tumour grade.CXCR4 expression in the primary tumour was significantly higher in tumours that recurred as compared with those that did not recur (median 60%, IQR 33–72 vs 12%, IQR 1–70, Kruskal-Wallis p=0.01). After dichotomisation, >25% of CXCR4 expressions proved an independent prognosticator for a reduced recurrence-free survival (RFS) (HR 7.2, 95% CI 1.5 to 72.4, p=0.04).ConclusionCXCR4 is expressed in the majority of primary AdCCs and independently correlated to worse RFS, suggesting CXCR4 as a target for imaging and therapy purposes in patients with advanced AdCC.

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Adenoid Cystic Carcinoma

Cited by 8 publications

References 185 publications

Perivascular spread of adenoid cystic carcinoma: a novel imaging sign

Perivascular spread of adenoid cystic carcinoma: a novel imaging sign

Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target

High CXCR4 expression in adenoid cystic carcinoma of the head and neck is associated with increased risk of locoregional recurrence

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