Tumor Angiogenesis as a Prognostic Factor in Early Oral Tongue Cancer

Shpitzer, Thomas; Chaimoff, Moshe; Gal, Rivka; Stern, Yoram; Feinmesser, Raphael; Segal, Karl

doi:10.1001/archotol.1996.01890200055012

Cited by 63 publications

(39 citation statements)

References 15 publications

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“…Cancer staging is based on the TNM system, which has been labeled as imperfect, per se, for prognostic purposes. 8,9,12,13,[26][27][28][29][30] However, the vast majority of authors accepts that disease staging has a crucial influence on the outcome. Guerra et al 31 reported 5-year survival rates of 82% for initial stages and 49% for advanced disease.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…41,42 Other methods have been developed to evaluate angiogenesis, such as the Chalkley method and flow cytometry vessel counting. 41,42 Using the MVD technique, Shpitzer et al 28 have studied early-stage tongue SCC angiogenesis, reporting that it may be an important factor for tumor hostility. Marked angiogenesis correlated well with the risk of nodal metastases and should probably imply a more aggressive postoperative adjuvant therapy.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

View full text Add to dashboard Cite

“…A neoangiogênese é um processo essencial para o desenvolvimento tumoral e tem sido relacionada com a capacidade de metastatização e o prognóstico em neoplasias malignas de diversos sítios anatômicos. Embora a metastatização seja a característica mais marcante das neoplasias malignas, os resultados de diferentes estudos realizados em carcinomas de boca têm se mostrado conflitantes quanto à importância da densidade microvascular e sugerem que o método, desenvolvido em outras neoplasias, necessita de adaptação 4,5,6 . Este estudo tem por objetivo avaliar a densidade da neoangiogênese nos carcinomas epidermóides de língua, (tumor primário e metástases linfonodais), relacionando estes achados com a presença de metástase ou recidiva.…”

Section: Introductionunclassified

Densidade microvascular no carcinoma de língua

Amar¹,

Giovanini²,

Rosa³

et al. 2002

Rev. Assoc. Med. Bras.

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“…In this process, the main blood supply to a tumor derives from the growth and extension of pre-existing blood vessels (angiogenesis), but circulating endothelial cell precursors may contribute to the growing vascular tree as well (vasculogenesis). 3,4 In head and neck squamous cell carcinoma, the quantification of tumor angiogenesis by intratumoral microvessel counting correlates with poor clinical outcome, 5,6 but results of various studies are conflicting and inconclusive in regard of the size of the estimated risk. 7,8 A number of putative angiogenic factors such as basic fibroblast growth factor, platelet-derived growth factor, interleukins, and vascular endothelial growth factor (VEGF), are expressed in head and neck squamous cell carcinoma.…”

mentioning

confidence: 99%

Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth factor receptor-2

et al. 2005

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Vascular endothelial growth factor is a peptide with well-defined actions on the vasculature and fundamental role in tumor angiogenesis. Its action in vascular endothelium is exerted in a paracrine manner. The immunohistochemical expression of this protein by cancer cells in head and neck squamous cell carcinoma was correlated with increased tumor aggressiveness and poor survival in previous studies. In the past years, an increasing amount of studies demonstrated potential autocrine action of vascular endothelial growth factor in various neoplasms. However, the existence and the impact of such autocrine action in head and neck cancer have not been demonstrated yet. In this retrospective study, we evaluated the expression of vascular endothelial growth factor and its receptors in neoplastic cells, in a cohort of patients with head and neck squamous cell carcinoma, and compared this expression with tumor aggressiveness, clinicopathologic parameters and outcome. High expression of vascular endothelial growth factor was strongly correlated with high expression of vascular endothelial growth factor receptor-2 (but not vascular endothelial growth factor receptor-1) on the cancer cells (Po0.001). The co-overexpression of both the protein and vascular endothelial growth factor receptor-2 was associated with higher tumor proliferation rate (Po0.001). The above cooverexpression also correlated with worse survival (log rank Po0.05) in patients with oral-larynx squamous cell carcinoma. Our results suggest that an autocrine vascular endothelial growth factor loop, mediated via vascular endothelial growth factor receptor-2, probably exists in head and neck squamous cell carcinoma. These observations support the hypothesis that the use of vascular endothelial growth factor receptor-2 inhibitors as adjuvant antiangiogenic therapy might have beneficial effects for these patients, by disrupting both paracrine (endothelial-dependent) and autocrine actions of vascular endothelial growth factor.

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Tumor Angiogenesis as a Prognostic Factor in Early Oral Tongue Cancer

Cited by 63 publications

References 15 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Densidade microvascular no carcinoma de língua

Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth factor receptor-2

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