Tumeurs juvéniles de la granulosa : expression clinique et moléculaire

Kalfa, Nicolas; Philibert, Pascal; Patte, Catherine; Thibaud, E; Pienkowski, Catherine; Ecochard, Aude Mariani; Boizet-Bonhoure, Brigitte; Fellous, Marc; C, Sultan

doi:10.1016/j.gyobfe.2008.06.026

Cited by 22 publications

(16 citation statements)

References 109 publications

(135 reference statements)

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“…Les tumeurs de la granulosa juvéniles constituent une entité anatomopathologique particulière qui représente 5% des tumeurs ovariennes de l'enfant et de l'adolescente [ 1 ]. La forme juvénile des tumeurs de la granulosa est diagnostiquée chez des patientes de moins de 20ans dans 80% des cas, et moins de 10ans dans 50% des cas, d'où son appellation [ 2 ].…”

Section: Discussionunclassified

“…Parfois, la douleur est aigue, résultant de la torsion de l'ovaire leure nature hémorragique. Exceptionnellement les tumeurs de la granulosa peuvent se présenter sous forme d'un tableau de rupture avec hémopéritoine et ceci du fait de leur nature hémorragique [ 1 – 5 ]; un syndrome endocrinien lié aux fonctions sécrétrices de ces tumeurs: pseudo-puberté précoce isosexuelle chez la jeune fille en cas de sécrétion oestrogénique; hirsutisme, hypertrophie clitoridienne en cas de sécrétion androgénique [ 6 ]. Dans le cas de notre patiente on a retrouvé la masse abdomino-pelvienne qui était isolée, sans signes d'hypersécrétion.…”

Section: Discussionunclassified

“…La lutéinisation est fréquente. Le marqueur à la vimentine est positif dans 80% des cas environ [ 1 – 8 ]. Ces aspects macroscopique et microscopique ont été retrouvés dans notre cas, avec une forte positivité de l'anticorps anti-Vimentine.…”

Section: Discussionunclassified

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Tumeur juvénile de la granulosa de l’ovaire: à propos d’un cas

Azahouani¹,

Balahcen²

2015

Pan Afr Med J

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Ovarian sex cord tumors are rare tumors that develop at the expense of non-germ cell ovarian. The pathogenesis of these tumors remains undetermined and several cellular and molecular alterations may be involved in the development of juvenile granulosa cell tumors. For two decades, the individualization of juvenile granulosa cell tumors has been a major advance in the treatment of these children's tumors. However, their natural history is reported in the literature and through a short series and reliable prognostic factors are to establish. We report the case of a girl of 8 years who presented with abdominal-pelvic mass gradually increasing size, to surgical exploration found a huge abdominal mass at the expense of the left ovary. Histology and objective immunolabeling a tumor of the juvenile form of granulosa.

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Section: Discussionunclassified

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Tumeur juvénile de la granulosa de l’ovaire: à propos d’un cas

Azahouani¹,

Balahcen²

2015

Pan Afr Med J

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“…[78] Activating mutations of G alphas are present in 30%. [9] Tumors expressing FOXL2 present with precocious pseudopuberty. Disruption of SMAD1/5 or activation of SMAD2/3 has been linked to the pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature

Haroon

Agarwal

Pandey

et al. 2013

Indian J Endocr Metab

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The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumor of the ovary–and a brief literature review. A 7-year-old girl presented with rapid onset of pubertal development and elevated estradiol levels. Abdominal ultrasound revealed a mass in the right adnexa. Other causes of precocious puberty were excluded. Elective surgery was planned, but the patient presented to the emergency room with torsion of ovary. She underwent an exploratory laparotomy for tumor resection and right salpingo oophorectomy. Pathology reported a juvenile granulosa cell tumor of the ovary. Postoperatively, she experienced a cessation of vaginal bleeding and estradiol levels normalized. Early stage disease has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

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“…The complaint that is common among these patients is a palpable mass in lower abdomen. Ascites in 10% of them is reported [4]. This tumor can present in divers ages from infancy to teenage but it mostly presents in the age of 8 or 9 years old [5].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Cause of Precocious Puberty in an 8-Year-Old Girl Ended up in Juvenile Granulosa and Theca Cell Tumor of the Ovary

Ordooei¹,

Karimi-Zarchi²,

Malekzadeh³

et al. 2013

JCT

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Isosexual precocious puberty in girls has several etiologies. Juvenile granulose cell tumor is one of the rarest causes that only stands for 1.5% of ovarian cancers. This tumor mostly encounters in first 2 decades of life. This paper is a report of an 8-year-old girl with precocious puberty that within five months developed breast enlargement followed by menarche. Works which are done to find the underlying cause of precocious puberty revealed juvenile granulosa cell tumor in her left ovary. She then under went laparoscopic surgery and 3 courses of chemotherapy. She did not experience any vaginal bleeding after that and the serum level of estradiol lay among its normal ranges, but after that the tumor relapsed and presented as abdominal pain and a huge mass which under went resection of all afflicted tissues. After 2 courses of chemotherapy, her status deteriorated and unfortunately she died after 6 months from the time of diagnosis. Treatment for this disease is consists of resection surgery and chemotherapy. If this tumor is diagnosed in its early stages, it will be curable, but in its advanced stages, up to 80% of patients die from recurrent tumors. The reported patient was diagnosed at stage IIIC that had poor prognosis.

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Tumeurs juvéniles de la granulosa : expression clinique et moléculaire

Cited by 22 publications

References 109 publications

Tumeur juvénile de la granulosa de l’ovaire: à propos d’un cas

Tumeur juvénile de la granulosa de l’ovaire: à propos d’un cas

Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature

Investigation of the Cause of Precocious Puberty in an 8-Year-Old Girl Ended up in Juvenile Granulosa and Theca Cell Tumor of the Ovary

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