Tumeur d’Abrikossoff juxta axillaire: une localisation rare d’une tumeur très rare, à propos d’un cas

Amourak, Sarah; Bouzoubaa, Wael; Jayi, Sofia; Alaoui, Fatimazahra Fdili; Chaara, Hikmat; Melhouf, Moulay Abdelilah

doi:10.11604/pamj.2015.21.164.6622

Cited by 3 publications

(1 citation statement)

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“…For Jardines, only the presence of metastases with anatomopathological characteristics similar Open Journal of Obstetrics and Gynecology to those of the primary tumor can confirm the malignant character [2]. The management is usually surgical, consisting of a wide resection with a favorable evolution in case of complete resection [6] [7].…”

Section: Introductionmentioning

confidence: 99%

Abrikossof’s Tumor: Report of a Case

Niang¹,

Mbodji²,

Gueye³

et al. 2023

OJOG

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The granular cell tumor of the breast is a rare tumor and a usually benign disease that appears clinically and radiologically like a malign tumor. We report a case of GCT in a woman of 41 years, who present a clinically and radiologically suspect later. The anatomopathological examination showed the benign tumor proliferation and a large tumorectomy was realized. The immunostaining with PS100 and NSE protein confirm the nature of the tumor.

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Section: Introductionmentioning

confidence: 99%

Abrikossof’s Tumor: Report of a Case

Niang¹,

Mbodji²,

Gueye³

et al. 2023

OJOG

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Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle

et al. 2015

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The clinical evolution and biology of granular cell tumors (GCT) are poorly understood and treatment remains an issue of discussion. The majority of GCT are benign, although some display malignant behavior. The distinction between benign, atypical, and malignant GCT is controversial due to morphological and immunohistochemical overlap and lack of consistent histological and phenotypic criteria that predict behavior. Although histological criteria may indicate increased risk of malignant evolution, some GCT with evident benign appearance exceptionally progress towards metastatic disease. In this review, we discuss current knowledge on GCT, including histologic, immunophenotypic, and molecular characteristics and differential diagnosis. We focus on the following problematic items in GCT: (1) evolution of classification, (2) neural versus non-neural GCT, (3) neoplastic versus reactive disease, (4) malignant transformation of benign GCT, and (5) multiple versus metastatic GCT. We conclude that although a Ki-67 index >10 % and the presence of mitoses and/or of necrosis are frequently associated with malignant behavior, metastasis remains the only unequivocal sign of malignancy in GCT. An infiltrative growth pattern and vascular and/or perineural invasion are not indicative of malignancy. GCT with atypical/uncertain features almost never metastasize, and many of these tumors either behave in a benign fashion or only recur locally (similar to incompletely excised benign tumors). We therefore propose that classical and atypical histological variants form a single group of GCT. GCT with various unfavorable histological features might be labeled as "GCT with increased risk of metastasis" rather than malignant GCT.

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