Tubular Adenomas With Minor Villous Changes Show Molecular Features Characteristic of Tubulovillous Adenomas

Ishii, Tatsushiro; Notohara, Kenji; Umapathy, Aarti; Mallitt, Kylie‐Ann; Chikuba, Hiroshi; Moritani, Yoshiaki; Tanaka, Noriaki; Rosty, Christophe; Matsubara, Nagahide; Jass, Jeremy R.; Leggett, Barbara A.; Whitehall, Vicki

doi:10.1097/pas.0b013e318205df20

Cited by 26 publications

(21 citation statements)

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“…41 Villous phenotype thus reflects malignant potential, with large (>10 mm) and purely villous lesions at highest risk of malignant transformation. In view of their increased malignant potential, more frequent surveillance screening has been recommended in this group.…”

Section: Villous Histologymentioning

confidence: 98%

Pathology of polyps detected in the bowel cancer screening programme

Foss¹,

West²,

McGregor³

2011

Diagnostic Histopathology

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Section: Villous Histologymentioning

confidence: 98%

Pathology of polyps detected in the bowel cancer screening programme

Foss¹,

West²,

McGregor³

2011

Diagnostic Histopathology

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“…[12] The current work found that MMP-7 over expression was significantly correlated with severe degree of dysplasia, villous configuration and large size (≥ 1cm). In keeping with these results, Kirimlioglu et al ., revealed that the degree of MMP-7 over expression was significantly higher in villous type and high grade dysplasia.…”

Section: Discussionmentioning

confidence: 75%

Immunohistochemical expression of matrix metalloproteinase-7 in human colorectal adenomas using specified automated cellular image analysis system: A clinicopathological study

Qasim

Ali

2013

Saudi J Gastroenterol

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Background/Aim:To evaluate the immunohistochemical expression of matrix metalloproteinase-7 (MMP-7) in colorectal adenomas, and to correlate this expression with different clinicopathological parameters.Patients and Methods:The study was retrospectively designed. Thirty three paraffin blocks from patients with colorectal adenoma and 20 samples of non-tumerous colonic tissue taken as control group were included in the study. MMP-7 expression was assessed by immunohistochemistry method. The scoring of immunohistochemical staining was conducted utilizing a specified automated cellular image analysis system (Digimizer).Results:The frequency of positive immunohistochemical expression of MMP-7 was significantly higher in adenoma than control group (45.45% versus 10%) (P value < 0.001). Strong MMP-7 staining was mainly seen in adenoma cases (30.30%) in comparison with control (0%) the difference is significant (P < 0.001). The three digital parameters of MMP-7 immunohistochemical expression (Area (A), Number of objects (N), and intensity (I)) were significantly higher in adenoma than control. Mean (A and I) of MMP-7 showed a significant correlation with large sized adenoma (≥ 1cm) (P < 0.05), also a significant positive correlation of the three digital parameters (A, N, and I) of MMP-7 expression with villous configuration and severe dysplasia in colorectal adenoma had been identified (P < 0.05).Conclusion:MMP-7 plays an important role in the growth and malignant conversion of colorectal adenomas as it is more likely to be expressed in advanced colorectal adenomatous polyps with large size, severe dysplasia and villous histology. The use of automated cellular image analysis system (Digmizer) to quantify immunohistochemical staining yields more consistent assay results, converts semi-quantitative assay to a truly quantitative assay, and improves assay objectivity and reproducibility.

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“…It is possible that mutation of BRAF with or without promoter methylation of MLH1 may define one methylator pathway, whereas the methylation of MGMT and KRAS mutation could characterize an "alternate methylator" subtype. 6 The precursor lesions for these ultimately KRAS mutant/MGMT methylated cancers may be tubular adenomas with villous changes, 49 but this area requires further research.…”

Section: Serrated Pathwaymentioning

confidence: 99%

Epigenetic Regulation and Colorectal Cancer

Matsubara

2012

Diseases of the Colon &Amp; Rectum

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Epigenetic silencing of genes is now recognized to be an important mechanism for inactivation of tumor suppressor genes in carcinogenesis. Because the role of genetic alterations in colorectal carcinogenesis has been well studied, colorectal cancer also offers an excellent model for elucidation of epigenetic mechanisms involved in carcinogenesis. DNA methylation and histone modification are involved in a complex network to maintain gene silencing and cause carcinogenesis. DNA methylation of cancer-related gene promoters generally begins early in the process of tumorigenesis, affecting various types of colorectal cancer to differing degrees. These advances in the understanding of the biology of tumorigenesis can be expected to provide distinct biomarkers that will aid future diagnosis, risk assessment, and treatment methods for patients with colorectal cancer.

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Tubular Adenomas With Minor Villous Changes Show Molecular Features Characteristic of Tubulovillous Adenomas

Cited by 26 publications

References 0 publications

Pathology of polyps detected in the bowel cancer screening programme

Pathology of polyps detected in the bowel cancer screening programme

Immunohistochemical expression of matrix metalloproteinase-7 in human colorectal adenomas using specified automated cellular image analysis system: A clinicopathological study

Epigenetic Regulation and Colorectal Cancer

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