Tuberculosis in patients with idiopathic pulmonary fibrosis

Novikova, Lubov; Ilkovich, Yulia; Speranskaya, A. A.

doi:10.1183/13993003.congress-2015.pa2046

Cited by 4 publications

(5 citation statements)

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“…Thus, clinical information from MTB and influenza A infections might be useful in the management of coronaviruses infections. MTB infection has been shown to provoke IPF progression, 30 and a five times higher incidence of tuberculosis in IPF than in the general population was described. 31 Influenza A immune response was prominently related to the development of AE-IPF.…”

Section: Discussionmentioning

confidence: 99%

“A Chain Only as Strong as Its Weakest Link”: An Up-to-Date Literature Review on the Bidirectional Interaction of Pulmonary Fibrosis and COVID-19

Criṣan-Dabija

Pavel²,

Popa³

et al. 2020

J. Proteome Res.

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The COVID-19 pandemic rapidly became a worldwide healthcare emergency affecting millions of people, with poor outcomes for patients with chronic conditions and enormous pressure on healthcare systems. Pulmonary fibrosis (PF) has been cited as a risk factor for a more severe evolution of COVID-19, primarily because its acute exacerbations are already associated with high mortality. We reviewed the available literature on biochemical, pathophysiological, and pharmacological mechanisms of PF and COVID-19 in an attempt to foresee the particular risk of infection and possible evolution of PF patients if infected with SARS-COV-2. We also analyzed the possible role of medication and risk factors (such as smoking) in the disease’s evolution and clinical course. We found out that there is a complexity of interactions between coexisting idiopathic pulmonary fibrosis/interstitial lung disease (ILD) and COVID-19 disease. Also, patients recovering from severe COVID-19 disease are at serious risk of developing PF. Smokers seem to have, in theory, a chance for a better outcome if they develop a severe form of COVID-19 but statistically are at much higher risk of dying if they become critically ill.

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Section: Discussionmentioning

confidence: 99%

“A Chain Only as Strong as Its Weakest Link”: An Up-to-Date Literature Review on the Bidirectional Interaction of Pulmonary Fibrosis and COVID-19

Criṣan-Dabija

Pavel²,

Popa³

et al. 2020

J. Proteome Res.

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“…Novikova L. et al (2015) [9] described an atypical course of tuberculosis, which made it difficult to diagnose in a patients with resistant tuberculosis and IPF. In the presented case, there were no difficulties in diagnosing tuberculosis, especially since the patient responsibly underwent an annual preventive fluorographic examination.…”

Section: Discussionmentioning

confidence: 99%

“…Novikova L. et al (2015) [9] conducted a retrospective analysis of the combined course of pulmonary tuberculosis and IPF. A progressive course was noted in 12 patients with resistant tuberculosis developed due to the underlying IPF, and 9 patients (75 %) died within 2 to 24 months.…”

Section: ключові словаmentioning

confidence: 99%

Peculiarities of multidrug-resistant tuberculosis on the background of idiopathic pulmonary fibrosis (a clinical case report)

Raznatovska

Shalmina

Fedorets

et al. 2019

ZMJ

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Цель работы-ознакомление практикующих специалистов с особенностями течения мультирезистентного туберкулеза (МРТБ) легких у больного с идиопатическим легочным фиброзом (ИЛФ), который развился на фоне длительной экспозиции факторов внешней среды на рабочем месте.

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“…□ extrapulmonary TB, including pleural TB efussions, TB lymphadenopaties, miliar TB, osteoarticular TB, intestinal TB, urogenital TB, meningitis TB, and other forms. □ overweight (BMI = 25 to 30 kg/m 2 ) or obesity (BMI ≥ 30 kg/m 2 ) [33]; □ pre-existing severe or uncontrolled arterial hypertension [34]; □ lung cancer [35] or other neoplasies [36]; □ idiopathic lung fibrosis [37,38]; □ pre-existing advanced chronic heart failure [39]; □ hepatic, renal, or digestive chronic conditions that may result in weight loss and HIV infection…”

Section: Methodsmentioning

confidence: 99%

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Mihuta,

Socaci,

Hogea

et al. 2024

Medicina

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Background and Objectives: The concurrent occurrence of tuberculosis and COVID-19 coinfection poses significant clinical complexities, warranting a nuanced approach to diagnosis, management, and patient care. Materials and Methods: A retrospective, cross-sectional study was conducted on two groups: one comprising 32 patients with pulmonary TB (PTB) and COVID-19 co-infection, and one including 100 patients with COVID-19 alone. Data was collected from medical records, including patient history, clinical parameters, laboratory, imaging results, and patient outcome. Results: A lower BMI emerges as a significant marker suggesting underlying PTB in patients with SARS-CoV-2 co-infection. Type 2 diabetes mellitus increases the risk of death in PTB-SARS-CoV-2 co-infection. Co-infected patients show lymphocytopenia and higher neutrophil levels, CRP, transaminases, and D-dimer levels. Elevated CRP and ALT levels are linked to increased co-infection likelihood. Certain parameters like SpO2, CRP, ALT, AST, and D-dimer effectively differentiate between co-infected and COVID-19 patients. Platelet-to-lymphocyte ratio is notably higher in co-infected individuals. Lesion severity on imaging is significantly associated with co-infection, highlighting imaging’s diagnostic importance. Longer hospital stays are linked to co-infection but not significantly to death risk. Conclusions: Certain clinical and biological factors may serve as potential indicators of PTB co-infection in patients with SARS-CoV-2.

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Tuberculosis in patients with idiopathic pulmonary fibrosis

Cited by 4 publications

References 0 publications

“A Chain Only as Strong as Its Weakest Link”: An Up-to-Date Literature Review on the Bidirectional Interaction of Pulmonary Fibrosis and COVID-19

“A Chain Only as Strong as Its Weakest Link”: An Up-to-Date Literature Review on the Bidirectional Interaction of Pulmonary Fibrosis and COVID-19

Peculiarities of multidrug-resistant tuberculosis on the background of idiopathic pulmonary fibrosis (a clinical case report)

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

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