Tubal Function Abnormalities with Tubal Patency in Unexplained Infertility

Ikemoto, Yuko; Kuroda, Keiji; Kuribayashi, Yasutaka; Inoue, Masayasu

doi:10.1007/978-981-10-8690-8_3

Cited by 3 publications

(4 citation statements)

References 40 publications

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“…Approximately, similar to a study conducted by Meena et al [23] that showed incidence of Peritubal adhesion seen in 16.6% of cases.…”

Section: Detectedsupporting

confidence: 86%

“…The discovered abnormalities of our present study were (46.4%) higher than the findings of the study conducted by Kim GS et al [23] Tubal sacculation, constriction, fibrosis, and kinking are all reported with segmentation. Due to different inclusion criteria, the previous study excluded patients with endometriosis signs or symptoms, but the current study did not.…”

Section: Detectedcontrasting

confidence: 75%

“…Where in a study done by Kemoto et al [23]. In the laparoscopy group, endometriosis was found in 62.7% of patients with unexplained infertility.…”

Section: Detectedmentioning

confidence: 90%

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Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Hadwa

Farahat

Dawood

et al. 2022

JAMMR

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Background: Unexplained infertility is usually a diagnosis of exclusion. Thus, there must be an absence of an identifiable cause of infertility despite thorough testing and medical investigation demonstrating tubal patency, normal semen parameters, regular ovulation, normal ovarian reserve, and a normal endometrial cavity. Aim: This study aims to assess the prevalence of abnormal tubo-ovarian relationship in women with unexplained infertility by using laparoscopy. Methodology: This was a prospective study which was conducted on 30 couples with unexplained infertility. Evaluation of the tubo ovarian relation with laparoscopy for patient with unexplained infertility who desire spontaneous pregnancy. The main object of the corrective procedure is to get free mobile fallopian tube along with satisfactory tubo-ovaian relation. Results: There were 53.3% of cases had disturbed tubo-ovarian relation, many corrective measures done by laparoscopy, such as adhesiolysis for 30% of cases, excision of cysts for 6.7% of cases, MSH for 16.6% of cases and cauterization of endometriotic patches for 16.6% of cases. In the present study a pregnancy rate of 53,3% (9/16) was seen in cases that showed disturbed tubo ovarian relation and required operative intervention higher than other cases with no detected pathology (4/14) 47.7%. We were able to achieve a higher conception rate among cases owing to operative procedure. Conclusions: The ovum pick up by the fimbrial end of the tube is an essential determining factor for female infertility. The present study confirmed that laparoscopy provided a precise diagnosis of tubo ovarian factor and may switch the initial treatment of unexplained infertility.

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“…Approximately, similar to a study conducted by Meena et al [23] that showed incidence of Peritubal adhesion seen in 16.6% of cases.…”

Section: Detectedsupporting

confidence: 86%

Section: Detectedcontrasting

confidence: 75%

See 1 more Smart Citation

Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Hadwa

Farahat

Dawood

et al. 2022

JAMMR

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“…Tubal transport is an essential process for successful spontaneous pregnancy by controlling the interaction between gametes as well as delivering the fertilized ovum to the uterus for implantation [1][2][3]. Dysfunctions in tubal transport, such as failure to capture the oocytes or transport the ovum, can induce infertility or life-threatening ectopic pregnancy [4][5][6]. Within the oviduct, the two major effectors for tubal transport include the smooth muscle contractions and the coordinated ciliary beats [7,8].…”

Section: Introductionmentioning

confidence: 99%

Characterization of oviduct ciliary beat frequency using real time phase resolved Doppler spectrally encoded interferometric microscopy

He¹,

Qu²,

Jing³

et al. 2019

Biomed. Opt. Express

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Ciliary activity, characterized by the coordinated beating of ciliary cells, generates the primary driving force for oviduct tubal transport, which is an essential physiological process for successful pregnancies. Malfunction of the cilium in the fallopian tube, or oviduct, may increase the risk of infertility and tubal pregnancy that can result in maternal death. While many ex-vivo studies have been carried out using bright field microscopy, this technique is not feasible for the in-vivo investigation of oviduct ciliary beating frequency (CBF). Optical coherence tomography (OCT) has been able to provide in-vivo CBF imaging in a mouse model, but its resolution may be insufficient to resolve the spatial and temporal features of the cilium. Our group has recently developed the phase resolved Doppler (PRD) OCT method to visualize ciliary strokes at ultra-high displacement sensitivity. However, the cross-sectional field of view (FOV) may not be ideal for visualizing the surface dynamics of ciliated tissue. In this study, we report on the development of phase resolved Doppler spectrally encoded interferometric microscopy (PRD-SEIM) to visualize the oviduct ciliary activity within an en face FOV. This novel real time imaging system offers micrometer spatial resolution, sub-nanometer displacement sensitivity, and the potential for in-vivo endoscopic adaptation. The feasibility of the approach has been validated through ex-vivo experiments where the porcine oviduct CBF has been measured across different temperature conditions and the application of a drug. CBF ranging from 8 to 12 Hz have been observed at different temperatures, while administration of lidocaine decreased the CBF and deactivated the motile cilia. This study will serve as a stepping stone to in-vivo oviduct ciliary endoscopy and future clinical translations.

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Morphometric Characteristics of Angioarchitectonics of the Normal Uterine Tube Mucous Membrane and Under the Effect of Opioid During the Experiment

Podolyuk¹,

Vilkhova²,

Матешук-Вацеба³

2020

PSSS MS

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Introduction. In the modern world, the problem of drug use, especially among the youth, is considered to be of utmost importance. Female body’s susceptibility to the development of drug addiction is considerably higher than that of the male body. The study of blood supply of the uterine tube is relevant since the morphological rebuilding of the mucous membrane of the uterine tube, considering its functions, plays an important role in the pathogenesis of several diseases of the female reproductive system. Under the effect of pathological factors, including opioids, vessels became the main target, and their structural changes are the basis for the development of the pathological process and determine the peculiarities of clinical symptoms. Methods. The study was carried out on 34 sexually mature white female rats (4,5-6,0 months) with the bodyweight of 180-220 g. Angioarchitectonics of the uterine tube of female white rats was studied in double-blinded, placebo-controlled studies with distribution into a control group (intact rats that were accepted as a relative norm, n=10), a placebo-controlled group (n=9) that received 0.9% saline for the duration of the experiment, and 3 experimental groups (n=5 each) that were subjected to long-term opioid effect. Results. After 2 weeks of Nalbuphine administration for female white laboratory rat, the minor expansion of arterioles and capillaries was observed, their diameter increased. Arteriolovenular coefficient augmented. After 4 weeks of Nalbuphine administration, arterioles were convoluted, loss of clear outlines, expansion of lumen, irregularity of vessels caliber, microvessels with microaneurysms, areas with hemorrhage and obliteration of capillaries were detected. After six-week administration of nalbuphine, the hemomicrocirculatory blood flow of the uterine tube wall was at the stage of decompensation, the capillary component was almost destroyed, arterioles were abruptly twisted and distorted, their lumen was uneven, venules were expanded and distorted, additional arteriolovenular anastomoses were opened, indices of trophic activity of the tissue increased considerably. Conclusions. The vasotropic effect after six-week administration of nalbuphine demonstrated severe damage to the uterine tube hemomicrocirculatory blood flow.

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Tubal Function Abnormalities with Tubal Patency in Unexplained Infertility

Cited by 3 publications

References 40 publications

Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Characterization of oviduct ciliary beat frequency using real time phase resolved Doppler spectrally encoded interferometric microscopy

Morphometric Characteristics of Angioarchitectonics of the Normal Uterine Tube Mucous Membrane and Under the Effect of Opioid During the Experiment

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