TT Virus Infection Is Widespread in the General Populations from Different Geographic Regions

Abe, Kenji; Inami, Toshihiro; Asano, Kazue; Miyoshi, Chiaki; Masaki, Naohiko; Hayashi, Shigeki; Ishikawa, Ko Ichi; Takebe, Yutaka; Win, Khin Maung; El-Zayadi, Abdel-Rahman; Han, Kwang Hyub; Zhang, David Y.

doi:10.1128/jcm.37.8.2703-2705.1999

Cited by 83 publications

(26 citation statements)

References 12 publications

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“…This study showed a lower prevalence of TTV infection than that reported in the literature, 21,22 both for SLE patients (n = 17, 37.0%) and controls (n = 7, 15.2%).…”

Section: Discussioncontrasting

confidence: 65%

Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Costa¹,

Costa²,

Devalle³

et al. 2012

Rev. Bras. Reumatol.

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Recent studies on the torque teno virus (TTV), genus Anellovirus, have allowed formulating the hypothesis that TTV may trigger autoimmune rheumatic diseases or have some pathogenic role in them. Objectives: To determine the frequency of TTV infection in patients with systemic lupus erythematosus (SLE), the genetic diversity of TTV, the correlation between TTV infection and SLE clinical manifestations, and SLE clinical course and serological profi le. Patients and methods: Serum samples were obtained from 46 SLE patients treated at the University-Affi liated Hospital of Campo Grande (NHU/FAMED/UFMS), Brazil. For controls, serum samples were obtained from 46 healthy volunteer blood donors. Viral DNA was extracted from samples using the QIAamp DNA Blood Mini Kit (QIAGEN, Hilden, Germany) and amplifi ed using nested PCR. Results: Positivity for TTV was found in 17 (37%) of SLE patients and in only seven (15.2%) of the controls (z test, P = 0.03). There was no correlation between TTV infection, SLE clinical manifestations, SLE clinical course, and the serological profi le of the patients evaluated. Conclusion: Further studies on the presence of TTV in SLE patients are required.

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“…This study showed a lower prevalence of TTV infection than that reported in the literature, 21,22 both for SLE patients (n = 17, 37.0%) and controls (n = 7, 15.2%).…”

Section: Discussioncontrasting

confidence: 65%

Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Costa¹,

Costa²,

Devalle³

et al. 2012

Rev. Bras. Reumatol.

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“…Later, several genetically distant but closely related TTV-like viruses (TTVLs) were identified, including TUS01 [Takahashi et al, 2000], SEN-V [Tanaka et al, 2001], and TTV-like mini viruses (TTMV) [Mushahwar, 2000]. TTV is widely distributed throughout the world Abe et al, 1999]. Both, acute resolving and chronic persistent infections have been recognised among TTV-infected humans [Bendinelli et al, 2001;Luo et al, 2002].…”

Section: Introductionmentioning

confidence: 99%

Detection and genotyping of TT virus in healthy and subjects with HBV or HCV in different populations in the United Arab Emirates

Al-Moslih

AbuOdeh

2004

Journal of Medical Virology

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TT virus (TTV) and TTV-like viruses (TTVLs) have been reported to be associated with non-A-E hepatitis. To determine the rate of infection and genotypic characteristics of TTV in the United Arab Emirates (UAE), a total of 449 serum samples representing different populations in the UAE and comprising healthy as well as patients positive for HBsAg and HCV were screened. National subjects (n = 200) and non-nationals residing in the UAE (n = 249) were tested by PCR. The results obtained showed that the rate of TTV infection in healthy nationals, and those with HBsAg or antibody to HCV were 34.9, 97.9, and 95.7, respectively, compared to 89.1% (115/129), 89.2% (66/74), and 84.8% (39/46), respectively, in non-nationals. Sequence analysis of the untranslated region (UTR) using 71 clones generated from the PCR products of eight serum samples from healthy individuals (four nationals and four non-nationals) showed that 83.1% of the TTV clones were classified into groups 1-4, whereas 16.9% into possibly new genotype(s). The analysis also revealed that healthy national subjects carried multiple viruses. Phylogenetic analysis of representative sequences revealed clustering of clones into at least five major groups. Also, when compared to reference genotypes (from GenBank), two of our clones belonged to two previously identified genotypes. Non-significant gender differences were seen in all ethnic groups studied (P > 0.05). In conclusion, the rate of TTV infection in the UAE nationals is significantly lower (P < 0.05) than that of the non-nationals and several genotypes were isolated with common multi-infections.

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“…However, the role of these viruses in acute and chronic hepatitis could not been confirmed in more recent studies, and they have been proposed as insignificant in liver injury (14,15). TTV has also been found very common in general population, in some studies (16,17). Although TTV DNA and HGV RNA were found more frequent in patients with chronic B and C hepatitis in some studies, no pathogenic effect attributed to TTV and HGV infection could have been shown in liver (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Frequency of hepatitis G virus and transfusion-transmitted virus infection in type II diabetes mellitus

Güney

Kadayıfçı

Savaş

et al. 2004

International Journal of Clinical Practice

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The hepatitis G virus (HGV) and transfusion-transmitted virus (TTV) are recently defined hepatitis viruses that the pathogenic roles in liver diseases are still not clear. It has been well known that some hepatitis virus, such as hepatitis C, might have an affinity to pancreatic islet cells. To investigate the relationship between the newly defined hepatitis viruses and diabetes mellitus (DM), we studied the prevalence of TTV and HGV in a type 2 diabetic patient population. Serum samples of 60 patients with DM and 45 healthy volunteers as control were taken. HGV RNA and TTV DNA was investigated by polymerase chain reaction. HGV was detected in none of diabetic patients (0%) and only one in control group (2.2%). However, TTV DNA was detected in 16 patients with DM (26%) and in five controls (11%). TTV was more prevalent in diabetic patients, but the difference between groups was not statistically significant (p > 0.05). These results revealed that TTV is more common in diabetic patients than in controls. At present, we don't know if this result is only a coincidence or a sign of potential association between TTV and DM. Further studies are certainly needed to elucidate a potential relationship.

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TT Virus Infection Is Widespread in the General Populations from Different Geographic Regions

Abstract: By PCR screening, we found an extremely high prevalence of TT virus (TTV) in the general populations from different geographic regions. This suggests that TTV may be a common DNA virus with no clear disease association in humans. TTV genotyping by phylogenetic analysis was also performed.

Cited by 83 publications

References 12 publications

Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Detection and genotyping of TT virus in healthy and subjects with HBV or HCV in different populations in the United Arab Emirates

Frequency of hepatitis G virus and transfusion-transmitted virus infection in type II diabetes mellitus

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