Frequency of hepatitis G virus and transfusion-transmitted virus infection in type II diabetes mellitus

Güney, Çakır; Kadayıfçı, Abdurrahman; Savaş, Merve; Uygun, Ahmet; Balkan, Ayhan; Kubar, Ayhan

doi:10.1111/j.1742-1241.2004.00288.x

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Information regarding the prevalence of human anelloviruses in diabetic patients is limited. Earlier studies reported lower prevalence for TTV DNA in T2DM patients, of 26% (16/60) [ 30 ] and 54.7% [ 24 ]. Only the second study observed a different distribution of TTV DNA in diabetics vs. control group.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Spandole-Dinu

Cimponeriu

Crăciun³

et al. 2018

BMC Infect Dis

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BackgroundHuman anelloviruses (TTV, TTMDV and TTMV) are at high prevalence all across the globe, having also a controversial disease-inducing potential. This study aimed to estimate the prevalence of anelloviral DNA in the Romanian human population and to investigate the association of infections with common pathologies in Romanian population.MethodsAfter informed consent, blood samples were collected from 2000 subjects represented by: clinically healthy individuals (n = 701) and a group of patients with pathologies linked to low grade inflammation or alteration of carbohydrate metabolism (n = 1299). All samples were analysed for the presence of TTV, TTMDV and TTMV DNA by hemi-nested PCR.ResultsThe prevalence of TTV, TTMDV and TTMV in the studied population was 68.2, 54.4%, respectively 40.1%, lower than the recent reports from other geographic regions. The three viral species were significantly more frequent in the group of patients compared to the healthy subjects and were associated with type 2 diabetes mellitus. The presence of anelloviral DNA was also associated with medical procedures (e.g. haemodialysis/transfusions, surgical procedures) and previous hepatitis A virus infection. Lifestyle choices related to alcohol consumption, smoking, physical activity and living environment were not associated with differences in distribution of the three viruses.ConclusionFurther evidence is needed to establish a correlation between infection with human anelloviruses and a pathology or group of pathologies.

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Section: Discussionmentioning

confidence: 99%

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Spandole-Dinu

Cimponeriu

Crăciun³

et al. 2018

BMC Infect Dis

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“…Failure to link TTV to hepatitis has prompted attempts to associate TTV and, much less frequently, the other anelloviruses to a variety of other cryptogenetic diseases. Potential associations have been described with multiple sclerosis (MS) 83, systemic lupus erythematosus 27, pancreatic cancer 84, diabetes mellitus 85, laryngeal cancer 86, cancer in general 87–92, periodontal disease 93, and certain rheumatic diseases 94. Moreover, emerging evidence indicates that TTV may replicate actively in the respiratory tract of children and possibly be a cause of acute respiratory diseases 35, 95 and/or an aggravating factor in these as well as in two chronic respiratory diseases believed to be multifactorial in nature, namely asthma 96 and bronchiectasia 97.…”

Section: Anelloviruses and Diseasementioning

confidence: 99%

Human anelloviruses and the central nervous system

Maggi

Bendinelli

2010

Reviews in Medical Virology

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Torque teno virus and related anelloviruses are a recent addition to the list of agents that cause chronic productive infections and high levels of plasma viraemia in humans. Many aspects of the natural history and pathogenesis of these under many respects surprising viruses are still poorly understood. In this review, we briefly outline the general properties of anelloviruses, examine what is currently known about the interactions they establish with the central nervous system (CNS), and discuss the possible pathological consequences.

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Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Lontchi-Yimagou

Feutseu

Kenmoe

et al. 2021

Sci Rep

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A significant number of studies invoked diabetes as a risk factor for virus infections, but the issue remains controversial. We aimed to examine whether non-autoimmune diabetes mellitus enhances the risk of virus infections compared with the risk in healthy individuals without non-autoimmune diabetes mellitus. In this systematic review and meta-analysis, we assessed case-control and cohort studies on the association between non-autoimmune diabetes and viruses. We searched PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Web of Science with no language restriction, to identify articles published until February 15, 2021. The main outcome assessment was the risk of virus infection in individuals with non-autoimmune diabetes. We used a random-effects model to pool individual studies and assessed heterogeneity (I2) using the χ2 test on Cochrane’s Q statistic. This study is registered with PROSPERO, number CRD42019134142. Out of 3136 articles identified, we included 68 articles (90 studies, as the number of virus and or diabetes phenotype varied between included articles). The summary OR between non-autoimmune diabetes and virus infections risk were, 10.8(95% CI: 10.3–11.4; 1-study) for SARS-CoV-2; 3.6(95%CI: 2.7–4.9, I2 = 91.7%; 43-studies) for HCV; 2.7(95% CI: 1.3–5.4, I2 = 89.9%, 8-studies;) for HHV8; 2.1(95% CI: 1.7–2.5; 1-study) for H1N1 virus; 1.6(95% CI: 1.2–2.13, I2 = 98.3%, 27-studies) for HBV; 1.5(95% CI: 1.1–2.0; 1-study) for HSV1; 3.5(95% CI: 0.6–18.3 , I2 = 83.9%, 5-studies) for CMV; 2.9(95% CI: 1–8.7, 1-study) for TTV; 2.6(95% CI: 0.7–9.1, 1-study) for Parvovirus B19; 0.7(95% CI: 0.3–1.5 , 1-study) for coxsackie B virus; and 0.2(95% CI: 0–6.2; 1-study) for HGV. Our findings suggest that, non-autoimmune diabetes is associated with increased susceptibility to viruses especially SARS-CoV-2, HCV, HHV8, H1N1 virus, HBV and HSV1. Thus, these viruses deserve more attention from diabetes health-care providers, researchers, policy makers, and stakeholders for improved detection, overall proper management, and efficient control of viruses in people with non-autoimmune diabetes.

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Frequency of hepatitis G virus and transfusion-transmitted virus infection in type II diabetes mellitus

Cited by 4 publications

References 18 publications

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Human anelloviruses and the central nervous system

Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

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