Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Costa, Márcio Reis da; Costa, Izaías Pereira da; Devalle, Sylvie; Castro, Ana Rita; Freitas, Solange Zacalusni

doi:10.1590/s0482-50042012000100006

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…ii) TTV and AV-sp, which exhibited relatively low positive rates, are categorized as non-pathogenic anelloviruses that are believed to be widely present in the human blood virome 23 . It is noteworthy that multiple studies have reported a higher positive rate of anelloviruses in SLE patients compared to that in healthy people 30,35 . Our results concerning VSIGs suggested that TTV, compared to other viruses, had a highly similar expression profile with HHV5 after viral infection of SLE patients (Figure S2), implying a possible similar mechanism of their influences on SLE.…”

Section: Discussionmentioning

confidence: 94%

Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease

Wu,

Zhang,

Liu

et al. 2023

Preprint

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Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Many viruses have been reported to be associated with SLE, but the diversity of the virome in SLE and the mechanisms underlying the interactions between viral infection and SLE are still unclear. This study identified ten human virus species from 826 RNA-Seq samples of human blood from 688 SLE patients and 138 healthy controls. SLE patients were found to have higher positive rates of viruses than healthy controls, although the virus abundances were low and comparable in both SLE patients and healthy controls. Analysis of the antiviral interferon-stimulated genes (ISGs) in samples showed higher ISG expression levels in virus-positive samples compared to virus-negative samples, which confirmed viral infections in virus-positive samples. Further analysis of differential expression genes between virus-positive and negative SLE patients showed that several genes that were up-regulated in SLE patients were further up-regulated after viral infections, and they were mainly enriched in immune response-related biological processes, suggesting an excess immune response in SLE patients after viral infections. Finally, three marker genes of the SLE severity, namely STAT1, STAT5A, and STAT5B, showed higher expression levels in virus-positive SLE patients compared to those in virus-negative SLE patients, suggesting that viral infections may aggravate the SLE disease. Overall, the study deepens our understanding of the association between viruses and SLE and provides new insights into prevention and control of the disease.

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Section: Discussionmentioning

confidence: 94%

Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease

Wu,

Zhang,

Liu

et al. 2023

Preprint

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“…Segundo Costa et al (2012), entende-se por sintomas inespecíficos de LES, fadiga, mal-estar, febre baixa, perda de peso e adenomegalia e que costuma evoluir com períodos de atividade inflamatória com manifestações cutâneas e articulares, alterações hematológicas e sorológicas embora não se possa ignorar a possibilidade de manifestações isoladas em outros órgãos ou sistemas, manifestações muito incaracterísticas levam à perseguição de diagnósticos alternativos mais frequentemente.…”

Section: Lúpus Eritematoso Sistêmico (Les)unclassified

O papel da alimentação para a qualidade de vida de portadores de lúpus

Silva,

Freitas,

Lobo

2023

RSD

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O lúpus eritematoso sistêmico (LES) é uma patologia de caráter inflamatória crônica que pode acometer qualquer idade e gênero, mas, manifesta-se principalmente em mulheres em idade fértil, caracterizado por período de atividade da doença e remissão, onde o mesmo pode acometer múltiplos órgãos e sistemas. O presente estudo tem como foco principal abordar a importância da alimentação saudável para a qualidade de vida de portadores de lúpus. A metodologia tratasse de pesquisa descritiva com abordagem de revisão de literatura, demonstrar através de um levantamento bibliográfico sobre o estado nutricional e consumo alimentar de pacientes portadores de Lúpus Eritematoso Sistêmico. Em resultados obteve-se em maioria dos casos de pacientes lupicos com obesidade e sobrepeso e maior incidência da doença em mulheres em idade fértil, evidenciou-se baixo consumo de micronutrientes em comparação ao que recomendado pela literatura. Conclui-se que o excesso de peso e frequente no LES, e está relacionado com o consumo alimentar e que tem maiores chances de desenvolverem doenças metabólicas e cardiovasculares, não só pela má alimentação como também efeitos dos corticoides e antimaláricos que também afetam o quadro nutricional do paciente.

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“…TTV infection is not solely found in hepatitis or liver diseases but is also detected in other non-related liver diseases as well. The rate of TTV infection in diseases related to other systems such as respiratory, genetic and cancerous is proved to be significantly high in many studies (Pifferi et al, 2005;Alavi et al, 2011;Costa et al, 2012;Cimponeriu et al, 2013). The number of studies conducted to observe any association of TTV pathogenesis with any non-hepatic diseases are increased by the year.…”

Section: Prevalence Of Ttv In Non-hepatitis Diseasesmentioning

confidence: 99%

Torque Teno Virus and Hepatitis: A review on correlation.

Hazanudin

Othman

Kqueen

et al. 2019

lsmb

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Torque teno virus (TTV) is one of the "orphan" viruses that have been discovered almost two decades ago, with little information on the relationship of the infection to any diseases. It is one of the 45% of the commensal virus which is found throughout the population and becoming one of the most extensively studied viruses on its prevalence among the various level of health status. From healthy blood donors to patients who suffered severe illness, TTV infection level seems to be high and the findings have triggered interest from the researcher. Even though the study on TTV prevalence is actively performed, the actual pathogenesis of TTV to any specific diseases is yet to be ascertained. Many suggestions on the possible association of TTV infection with severe diseases such as acute respiratory diseases, liver-related diseases and even cancer have been discussed. However, one type of diseases which might have an association with TTV is hepatitis. Albeit, it remains a theory as the actual pathogenicity of TTV is not fully understood.

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Prevalência e diversidade genética do torque teno vírus em pacientes com lúpus eritematoso sistêmico em serviço de referência no Mato Grosso do Sul

Cited by 12 publications

References 38 publications

Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease

Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease

O papel da alimentação para a qualidade de vida de portadores de lúpus

Torque Teno Virus and Hepatitis: A review on correlation.

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