Trypanocidal activity of free and nanoencapsulated curcumin onTrypanosoma evansi

Abstract

This study aimed to evaluate in vitro and in vivo trypanocidal activity of free and nanoencapsulated curcumin against Trypanosoma evansi. In vitro efficacy of free curcumin (CURC) and curcumin-loaded in lipid-core nanocapsules (C-LNCs) was evaluated to verify their lethal effect on T. evansi. To perform the in vivo tests, T. evansi-infected animals were treated with CURC (10 and 100 mg kg(-1), intraperitoneally [i.p.]) and C-LNCs (10 mg kg(-1), i.p.) during 6 days, with the results showing that these treatments significantly attenuated the parasitaemia. Infected untreated rats showed protein peroxidation and an increase of nitrites/nitrates, whereas animals treated with curcumin showed a reduction on these variables. As a result, the activity of antioxidant enzymes (superoxide dismutase and catalase) differs between groups (P<0.05). Infected animals and treated with CURC exhibited a reduction in the levels of alanine aminotransferase and creatinine, when compared with the positive control group. The use of curcumin in vitro resulted in a better parasitaemia control, an antioxidant activity and a protective effect on liver and kidney functions of T. evansi-infected adult male Wistar rats.

Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis

“…In vitro and in vivo curcumin has shown antitrypanosomiasis effects in trypanosomal craniectomy as well as antimalarial effects in sickle-cell falciparum cultures and in vivo plasmodium flea [29]. Despite its numerous preferences, curcumin features several inalienable drawbacks such as diminished retention, destitute water dissolvability as well as diminished serum and tissue concentration.…”

Insight into Trypanosomiasis in Animals: Various Approaches for its Diagnosis, Treatment and Control: A Review

“…Currently, in vivo and in vitro trypanocidal activity of free and nanoencapsulated curcumin against Trypanosoma evansi is evaluated and found significant positive result to reduce parasitemia on adult male wistar rats (Gressler et al, 2015). Treatment with essential oil of achyrocline satureioides in rats infected with Trypanosoma evansi revealed that essential oil did not eliminate the parasites from the bloodstream, but it reduced the number of trypanosomes, mainly by its nanoencapsulated form so, association of this natural product with a trypanocidal drug may enhance its curative effect (Baldissera et al, 2014a).…”

Curcumin Nanoparticles Versus Curcumin in Amelioration of Inflammatory and Pathological Changes During the Migratory Phase of Murine Trichinellosis

“…Curcumin is an important bioactive compound of Curcuma longa with medicinal value such as anti-inflammatory, anticancer, antioxidant, anti-atherosclerotic, antibacterial, antiviral, antifungal, and wound healing (Moghadamtousi et al, 2014;Hussein et al, 2021), as well as anti-protozoal activity as Trypanosoma brucei (Gressler et al, 2015), Giardia lamblia (Pérez-Arriaga et al, 2006), Leishmania donovani (Cheikh- Ali et al, 2015), and significant effect on experimental cerebral malaria (Waknine-Grinberg et al, 2010) and Schistosoma mansoni (Hussein et al, 2017). Moreover, Cur had a beneficial role in animal models of liver toxicity, inflammation and cirrhosis (Lee et al, 2017) and multiple cardiovascular protective effects (Zeng et al, 2015).…”