Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis

El-Shafey, Aziza A.M.; Hegab, Mohammed H A; Seliem, Moshira M.E.; Barakat, Ashraf M.; Mostafa, Nabil H.; Abdel-Maksoud, Hanem A; Abdelhameed, Reda M.

doi:10.1007/s10856-020-06429-y

Cited by 28 publications

(21 citation statements)

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“…number and size of tissue cysts significantly decreased in mice inoculated with bradyzoites of Tehran strain and treated with CR-NE compared with that in negative control group (P<0.001). More recent, El-Shafey et al [8] showed that curcumin and curcumin incorporated in metal organic frameworks nanocomposite significantly decreased the mean count of cysts in brains of the treated rats infected with ME49 strain.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological and biochemical assessment of the therapeutic effect of gold nanoparticles on experimental chronic toxoplasmosis

GabAllah

Barakat

Ahmed

et al. 2021

Parasitologists United Journal

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The diagnosis of acute infection is established by the presence of tachyzoites in tissue parts and/or smears of body fluid (CSF, amniotic, or bronchoalveolar lavage fluids) [6] . The presence of several tissue cysts indicates the presence of a chronic infection [7] . In experimentally infected mice, histopathological smear analysis revealed that the chosen tissues for detecting T. gondii are the liver and spleen in the virulent strain (RH), and the brain and kidney in the avirulent strain (ME49) [8] .

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Section: Discussionmentioning

confidence: 99%

“…The presence of several tissue cysts indicates the presence of a chronic infection [7] . In experimentally infected mice, histopathological smear analysis revealed that the chosen tissues for detecting T. gondii are the liver and spleen in the virulent strain (RH), and the brain and kidney in the avirulent strain (ME49) [8] .…”

mentioning

confidence: 99%

Histopathological and biochemical assessment of the therapeutic effect of gold nanoparticles on experimental chronic toxoplasmosis

GabAllah

Barakat

Ahmed

et al. 2021

Parasitologists United Journal

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“…The tissue structure of the organs studied changed in the group of rats infected with T. gondii ME49 but not treated. Curcumin and curcumin NPs treatment enhanced the histomorphology of infected rats, which could be attributed to curcumin's antiinflammatory properties [99].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model

et al. 2021

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The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups. A total of 35 mice, 7 of which were negative control and 28 was infected group, were used in the current study. All mice were sacrificed at 45 day after inoculation. Blood samples were collected. Then, sera Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase 3 (SOD3), α-glutathione S-transferases (α-GST), and Interleukin 6 (IL-6) concentrations were measured using ELISA technique. In infected groups, CAT, SOD3, α-GST levels were decreased significantly (P<0.01), while MDA and IL-6 concentrations were significantly increased when compared to negative control (P<0.01). Treatment of infected mice with Kumquat-loaded chitosan nanoparticles were significantly improved (P<0.05) all parameters levels in sera and back them close to the original levels of negative control. The biochemical results are in parallel with histopathological and parasitological results. The findings imply that oxidative stress and parasitological changes may have a role in the aetiology and therapy of toxoplasmosis, particularly when Kumquat-loaded chitosan nanoparticles were used.

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“…Curcumin shows activity against different types of parasites in vitro and in vivo. The antiprotozoal activity of curcumin is shown against Leishmania major , Leishmania donovani [ 156 , 157 ], Trichomonas vaginalis [ 158 ], Entamoeba histolytica [ 159 ], Giardia lamblia [ 160 ], Toxoplasma gondii [ 161 ], Neospora caninum [ 162 ], etc. The combinations of netilmicin and curcumin and metronidazole and curcumin show a synergistic effect and can be used to treat leishmaniasis and amoebiasis, respectively [ 156 , 159 ].…”

Section: Biological Activities Of Curcuminmentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.

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Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis

Cited by 28 publications

References 50 publications

Histopathological and biochemical assessment of the therapeutic effect of gold nanoparticles on experimental chronic toxoplasmosis

Histopathological and biochemical assessment of the therapeutic effect of gold nanoparticles on experimental chronic toxoplasmosis

Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model

Curcumin: Biological Activities and Modern Pharmaceutical Forms

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