Trp64Arg polymorphism in<i>ADRB3</i>gene is associated with elite endurance performance: Table 1

Santiago, Catalina; Ruiz, Jonatan R.; Buxens, Amaya; Artieda, Marta; Arteta, David; González-Freire, Marta; Rodríguez-Romo, Gabriel; Altmäe, Signe; Lao, José I.; Gómez‐Gallego, Félix; Lucía, Alejandro

doi:10.1136/bjsm.2009.061366

Cited by 33 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The link between PPARGC1A gene and fat oxidative metabolism suggest that this gene may influence athletic performance on one hand, and prevention of obesity on the other hand. Additional examples of polymorphisms that were found to be associated with both obesity and elite athletic performance are the ADRB2 Arg16Gly (rs1042713) [26], [27], and the ADRB3 Trp64Arg (rs4994) [28], [29].…”

Section: Discussionmentioning

confidence: 99%

The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

et al. 2013

View full text Add to dashboard Cite

ObjectiveThe FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism.Subjects and MethodsA large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level.ResultsThere were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level).ConclusionThe FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics.

show abstract

Section: Discussionmentioning

confidence: 99%

The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The Arg389Gly variation in the β 1 AR gene ( ADRB1 ) influences exercise capacity phenotypes such as peak oxygen uptake (Defoor et al, 2006). The ADRB2 Gly16Arg (Wolfarth et al, 2007) and ADRB3 Trp64Arg polymorphisms are associated with elite endurance performance status (Santiago et al, 2009a). The AGT Met235Thr polymorphism is associated with power elite sports performance, with the C allele exerting a favorable effect vs endurance sports (Gomez‐Gallego et al, in press).…”

Section: Methodsmentioning

confidence: 99%

Can we predict top‐level sports performance in power vs endurance events? A genetic approach

Buxens¹,

Ruiz

Arteta³

et al. 2011

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

The goal of our study was to discriminate potential genetic differences between humans who are in both endpoints of the sports performance continuum (i.e. world-class endurance vs power athletes). We used DNA-microarray technology that included 36 genetic variants (within 20 different genes) to compare the genetic profile obtained in two cohorts of world-class endurance (N=100) and power male athletes (N=53) of the same ethnic origin. Stepwise multivariate logistic regression showed that the rs1800795 (IL6-174 G/C), rs1208 (NAT2 K268R) and rs2070744 (NOS3-786 T/C) polymorphisms significantly predicted sport performance (model χ(2) =25.3, df=3, P-value <0.001). Receiver-operating characteristic (ROC) curve analysis showed a significant discriminating accuracy of the model, with an area under the ROC curve of 0.72 (95% confidence interval: 0.66-0.81). The contribution of the studied genetic factors to sports performance was 21.4%. In summary, although an individual's potential for excelling in endurance or power sports can be partly predicted based on specific genetic variants (many of which remain to be identified), the contribution of complex gene-gene interactions, environmental factors and epigenetic mechanisms are also important contributors to the "complex trait" of being an athletic champion. Such trait is likely not reducible to defined genetic polymorphisms.

show abstract

“…However, there were no significant differences in allelic frequency between athletes and controls (n ¼ 33). Santiago et al [50] compared genotype frequencies of the ADRB3 Trp64Arg variation in 153 elite Caucasian Spanish athletes (100 world-class endurance athletes: runners and cyclists and 53 power athletes: sprinters, jumpers, and throwers) and 100 nonathletic controls. Endurance athletes had a higher 64Arg allele frequency comparing with controls (14.0% vs. 4.0%; P ¼ 0.001).…”

Section: Ace I Allelementioning

confidence: 99%

Current Progress in Sports Genomics

Ahmetov

Fedotovskaya

2015

Advances in Clinical Chemistry

163

164

View full text Add to dashboard Cite

Trp64Arg polymorphism inADRB3gene is associated with elite endurance performance: Table 1

Cited by 33 publications

References 29 publications

The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

Can we predict top‐level sports performance in power vs endurance events? A genetic approach

Current Progress in Sports Genomics

Contact Info

Product

Resources

About