The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

Eynon, Nir; Nasibulina, E. S.; Banting, Lauren K.; Cięszczyk, Paweł; Maciejewska-Karłowska, Agnieszka; Sawczuk, Marek; Бондарева, Э.А.; Shagimardanova, R R; Raz, Maytal; Sharon, Yael; Williams, Alun G.; Ahmetov, Ildus I.; Lucía, Alejandro; Birk, Ruth

doi:10.1371/journal.pone.0060570

Cited by 33 publications

(18 citation statements)

References 35 publications

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“…Similar results were found in a study reported by Eynon et al. 25 In this study, a total of 551 Caucasian subjects of European descent (Poland, Russia and Spain) were evaluated. At the end of the study, no association between FTO gene polymorphism and the physical performance of athletes was found.…”

Section: Discussionsupporting

confidence: 90%

Fto Polymorphism and Physical Fitness in Obese Schoolchildren After an Intervention Program

Moraes

Reuter

Klinger

et al. 2018

Rev Bras Med Esporte

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Introduction: Recent studies have shown that the association of FTO rs9939609 gene polymorphism with obesity depends on the level of the individual’s physical activity. However, there are some studies that evaluated physical fitness, health, and motor performance in relation to the rs9939609 FTO gene polymorphism. Objective: To evaluate how the rs9939609 FTO gene polymorphism affects the results of physical fitness tests related to health and athletic performance in schoolchildren after 4 months of intervention of physical exercise. Method: The rs9939609 FTO gene polymorphism was genotyped in a total of 36 schoolchildren from southern Brazil, aged 8 to 16 years. Body mass index (BMI), health-related physical fitness (cardiorespiratory fitness, abdominal strength/endurance, and flexibility) and motor performance (upper and lower limb strength, agility, and speed) were evaluated. The intervention included exercise strategies based on Physical Education, healthy eating, and oral and postural care. Results: In the experimental group, after the intervention, significant differences were noted in individuals with the TT genotype. These individuals showed improvements in abdominal strength (p=0.025), lower limb strength (p=0.037) and agility (p=0.021). For individuals with the AA/AT genotype, improvements in flexibility (p=0.026), abdominal strength (p=0.002), upper limb strength (p=0.008) and lower limb strength (p=0.001) were observed. However, these differences were not statistically significant when comparing the TT and AT/AA genotypes. Conclusions: The experimental group showed improvements in abdominal strength, lower limb strength, and speed. Yet, individuals with different genotypes (AA/AT and TT) for polymorphism rs9939609 exhibited similar values for indicators of physical fitness, health, and motor performance. Level of Evidence II; Lesser quality RCT.

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Section: Discussionsupporting

confidence: 90%

Fto Polymorphism and Physical Fitness in Obese Schoolchildren After an Intervention Program

Moraes

Reuter

Klinger

et al. 2018

Rev Bras Med Esporte

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“…Although these findings in West European populations support the hypothesis that the iron-increasing HFE rs1799945 G allele is favorable for endurance performance, replication studies in different ethnic groups using different designs are warranted. This approach leads to the exclusion of false-positive genetic associations (Eynon et al 2013;Zarebska et al 2017;Papadimitriou et al 2018;Yvert et al 2018;Guilherme et al 2019;Pickering et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis

et al. 2020

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Purpose Iron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented sports. The aim of the present study was to investigate the association between the HFE H63D polymorphism and elite endurance athlete status in Japanese and Russian populations, aerobic capacity and to perform a meta-analysis using current findings and three previous studies. Methods The study involved 315 international-level endurance athletes (255 Russian and 60 Japanese) and 809 healthy controls (405 Russian and 404 Japanese). Genotyping was performed using micro-array analysis or by PCR. VO 2max in 46 male Russian endurance athletes was determined using gas analysis system. Results The frequency of the iron-increasing CG/GG genotypes was significantly higher in Russian (38.0 vs 24.9%; OR 1.85, P = 0.0003) and Japanese (13.3 vs 5.0%; OR 2.95, P = 0.011) endurance athletes compared to ethnically matched controls. The meta-analysis using five cohorts (two French, Japanese, Spanish, and Russian; 586 athletes and 1416 controls) showed significant prevalence of the CG/GG genotypes in endurance athletes compared to controls (OR 1.96, 95% CI 1.58-2.45; P = 1.7 × 10-9). Furthermore, the HFE G allele was associated with high VȮ 2max in male athletes [CC: 61.8 (6.1), CG/GG: 66.3 (7.8) ml/min/kg; P = 0.036]. Conclusions We have shown that the HFE H63D polymorphism is strongly associated with elite endurance athlete status, regardless ethnicities and aerobic capacity in Russian athletes. Keywords Gene • Genotype • Hemochromatosis • Endurance performance • Athletes Abbreviations CI Confidence intervals DNA Deoxyribonucleic acid EDTA Ethylenediaminetetraacetic acid GWAS Genome-wide association studies HFE Homeostatic iron regulator (hemochromatosis gene) HH Hereditary hemochromatosis HWE Hardy-Weinberg equilibrium PCR Polymerase chain reaction RFLP Restriction fragment length polymorphism SNP Single-nucleotide polymorphism STREGA Strengthening the reporting of genetic association TFRC Transferrin receptor VȮ 2max Maximal oxygen consumption Communicated by Michael Lindinger.

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“…To avoid false-positive results, casecontrol studies should have at least one replication with additional athletic and nonathletic cohorts from different populations [2]. Since endurance and power are located at opposite extremes of the muscle performance continuum, the comparison of allelic frequencies between endurance and power athletes is also the way to identify endurance/power markers [3].…”

Section: Introductionmentioning

confidence: 99%

Current Progress in Sports Genomics

Ahmetov

Fedotovskaya

2015

Advances in Clinical Chemistry

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164

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The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes

Cited by 33 publications

References 35 publications

Fto Polymorphism and Physical Fitness in Obese Schoolchildren After an Intervention Program

Fto Polymorphism and Physical Fitness in Obese Schoolchildren After an Intervention Program

The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis

Current Progress in Sports Genomics

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